17 research outputs found
Mechanisms of regulation of experimental doxorubicin-induced immunosuppression of endogenous interferon inducer amixin
Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ»ΠΈ ΡΠΈΡΠΎΠΊΠΈΠ½Π·Π°Π²ΠΈΡΠΈΠΌΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΈ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠ΅ΠΉ ΠΈΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΠ½Π΄ΡΠΊΡΠΎΡΠΎΠΌ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π° Π°ΠΌΠΈΠΊΡΠΈΠ½ΠΎΠΌ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠ΅ΡΡΡΠ΅Ρ
ΡΠ°Π·ΠΎΠ²ΠΎΠ΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΌΡΡΠ°ΠΌ Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½Π° (1 ΡΠ°Π· Π² Π½Π΅Π΄Π΅Π»Ρ Π² Π΄ΠΎΠ·Π΅ 5,0 ΠΌΠ³/ΠΊΠ³) ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ³Π½Π΅ΡΠ΅Π½ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΠΊΡΠ΅ΡΠΎΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΠ΅ΡΠΈΡΠΎΠ½Π΅Π°Π»ΡΠ½ΡΡ
ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ² ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ Π±Π»Π°ΡΡΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΠΈΡ
ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΊ ΠΊΠΎΠΌΠΈΡΠΎΠ³Π΅Π½Π½ΠΎΠΌΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΠ-1Ξ² Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
in vitro. ΠΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½Π΄ΡΠΊΡΠΎΡΠ° ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π° Π°ΠΌΠΈΠΊΡΠΈΠ½Π° ΡΠΌΠ΅Π½ΡΡΠ°Π΅Ρ Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠ΅ΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΠ΅ΡΠΈΡΠΎΠ½Π΅Π°Π»ΡΠ½ΡΡ
ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ², Π²ΠΎΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°Π΅Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΉ ΡΠ΅Π·Π΅ΡΠ² ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°ΠΊΡΠΈΠ²ΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° ΠΏΡΠΈ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ² ΡΡΠ°ΡΠΈΠ»ΠΎΠΊΠΎΠΊΠΊΠ°ΠΌΠΈ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
in vitro ΠΈ ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΠΊ ΠΌΠΎΠ΄ΡΠ»ΠΈΡΡΡΡΠ΅ΠΌΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΠ-1Ξ² Π² ΡΠ΅Π°ΠΊΡΠΈΠΈ Π±Π»Π°ΡΡΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ².their specific activity is the actual problem of modern medicine. In this regard, special attention
was attracted to a national inducer of endogenous interferon amixin that is high means in the prevention
and treatment of viral diseases and secondary immune deficiencies. However, the molecular mechanisms
of action of immunotropic amixin and ability to use it for correcting violations of doxorubicininduced
immune disorders remain unclear. The aim was to study the role of cytokine-dependent processes
in formation mechanisms of doxorubicin-induced immunosuppression and the establishment
of opportunities for their pharmacological correction inducer of endogenous interferon amixin. It was
found that 4-course treatment of mice with doxorubicin (1 time per week at a dose of 5.0 mg/kg) leads
to inhibition of the activity of peritoneal macrophages and intensity of blasttransformation of peripheral
blood lymphocytes as a result of violations of their sensitivity to the comitogenic effects of IL-1Ξ² in
vitro. Prophylactic use of the inducer of endogenous interferon amixin reduces doxorubicin-induced
disorders of cytokine producing activity of peritoneal macrophages, restores functional reserve lymphocyte
activating factor production with additional stimulation of macrophages staphylococci in vitro
and increases the sensitivity of peripheral blood lymphocytes to the modulating effects of IL-1Ξ² in
reaction of blasttransformation of leukocyte
Phytotherapy in complex treatment of inflammatory periodontal diseases
ΠΠ΄Π½ΡΡΡ Π· Π½Π°Π³Π°Π»ΡΠ½ΠΈΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌ ΡΡΡΠ°ΡΠ½ΠΎΡ ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΡΡ
Ρ Π·Π°ΠΏΠ°Π»ΡΠ½Ρ Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Π½Ρ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠ°. ΠΡΡΠ°Π½Π½ΡΠΌ
Π΄Π΅ΡΡΡΠΈΠ»ΡΡΡΡΠΌ ΡΠΏΠΎΡΡΠ΅ΡΡΠ³Π°ΡΡΡΡΡ Π½Π΅Π³Π°ΡΠΈΠ²Π½Π°
ΡΠ΅Π½Π΄Π΅Π½ΡΡΡ ΡΠΎΠ·ΠΏΠΎΠ²ΡΡΠ΄ΠΆΠ΅Π½Π½Ρ Π·Π°ΠΏΠ°Π»ΡΠ½ΠΈΡ
Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Ρ
ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠ° ΡΠ΅ΡΠ΅Π΄ ΠΎΡΡΠ± Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΡΠ°ΡΠ΅Π·Π΄Π°ΡΠ½ΠΎΠ³ΠΎ Π²ΡΠΊΡ.
Π ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΌΡ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π·Π°ΠΏΠ°Π»ΡΠ½ΠΈΡ
Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Ρ
ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠ° Π²ΠΈΠΊΠΎΡΠΈΡΡΠΎΠ²ΡΡΡΡΡΡ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ½Ρ Π»ΡΠΊΠ°ΡΡΡΠΊΡ
Π·Π°ΡΠΎΠ±ΠΈ, ΡΠΊΡ ΠΌΠ°ΡΡΡ Π²Π΅Π»ΠΈΠΊΡ ΠΊΡΠ»ΡΠΊΡΡΡΡ ΠΏΠΎΠ±ΡΡΠ½ΠΈΡ
ΡΠ΅Π°ΠΊΡΡΠΉ.
Π’ΠΎΠΌΡ ΠΎΠ΄Π½ΠΈΠΌ Π· Π½Π°ΠΏΡΡΠΌΠΊΡΠ² ΠΏΠΎΡΡΠΊΡ Π½ΠΎΠ²ΠΈΡ
Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
Π·Π°ΡΠΎΠ±ΡΠ² Ρ Π°Π½Π°Π»ΡΠ· Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
ΡΠΎΡΠ»ΠΈΠ½ ΡΠ° ΡΠΈΡΠΎΠ²ΠΈΠ½ΠΈ, ΡΠΎ
ΠΌΡΡΡΠΈΡΡ Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎ Π°ΠΊΡΠΈΠ²Π½Ρ ΡΠ΅ΡΠΎΠ²ΠΈΠ½, ΡΠΊΡ ΠΌΠΎΠΆΡΡΡ
Π²ΠΏΠ»ΠΈΠ²Π°ΡΠΈ Π½Π° ΡΡΠ·Π½Ρ Π»Π°Π½ΠΊΠΈ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Ρ Π·Π°ΠΏΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡ
Ρ ΡΠΊΠ°Π½ΠΈΠ½Π°Ρ
ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠ° ΡΠ° ΠΌΠΎΠΆΡΡΡ Π±ΡΡΠΈ Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Ρ
Ρ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΌΡ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π³ΡΠ½Π³ΡΠ²ΡΡΡ ΡΠ° ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΈΡΡ.
ΠΠ΅ΡΠΎΡ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½ΡΠ±ΡΠ»ΠΎ ΠΏΡΠΎΠ°Π½Π°Π»ΡΠ·ΡΠ²Π°ΡΠΈ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ
Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
ΡΠΎΡΠ»ΠΈΠ½, Π»ΡΠΊΠ°ΡΡΡΠΊΠΎΡ ΡΠΎΡΠ»ΠΈΠ½Π½ΠΎΡ
ΡΠΈΡΠΎΠ²ΠΈΠ½ΠΈ ΡΠ° ΡΡΡΠΎΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡΠ² Ρ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΌΡ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ
Π·Π°ΠΏΠ°Π»ΡΠ½ΠΈΡ
Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Ρ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠ° ΡΠ° ΠΏΡΠΎΠ²Π΅ΡΡΠΈ
Π°Π½Π°Π»ΡΡΠΈΡΠ½ΠΈΠΉ ΠΏΠΎΡΡΠΊ Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
ΡΠΎΡΠ»ΠΈΠ½ ΡΠ° Π»ΡΠΊΠ°ΡΡΡΠΊΠΎΡ
ΡΠΎΡΠ»ΠΈΠ½Π½ΠΎΡ ΡΠΈΡΠΎΠ²ΠΈΠ½ΠΈ Π΄Π»Ρ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ Π½ΠΎΠ²ΠΈΡ
Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
Π·Π°ΡΠΎΠ±ΡΠ² Π΄Π»Ρ ΠΏΠΎΠ΄Π°Π»ΡΡΠΎΠ³ΠΎ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ Ρ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΎΠ»ΠΎΠ³ΡΡ
Π·Π° Π΄Π°Π½ΠΈΠΌΠΈ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΡ
, ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΈΡ
,
ΠΊΠ»ΡΠ½ΡΡΠ½ΠΈΡ
ΡΠ° ΠΎΠ³Π»ΡΠ΄ΠΎΠ²ΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ.
ΠΠ°ΡΠ΅ΡΡΠ°Π»ΠΈ Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈ. ΠΠΈΠ·Π°ΠΉΠ½ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π½ΠΎΡΠΈΠ²
ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΈΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ Π· Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Π½ΡΠΌ
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google.com/) ΡΠ° Π±Π°Π·ΠΈ Π΄Π°Π½ΠΈΡ
PubMed (https://pubmed.ncbi.
nlm.nih.gov/) ΡΠ· Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½ΡΠΌ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΈΡ
ΠΊΠ»ΡΡΠΎΠ²ΠΈΡ
ΡΠ»ΡΠ²: Β«medicinal plantsΒ», Β«dentistryΒ», Β«periodontitisΒ»
Β«gingivitisΒ», Β«oral bacteriaΒ», Β«porphyromonas
gingivalisΒ» Ρ ΡΡΠ·Π½ΠΈΡ
ΠΊΠΎΠΌΠ±ΡΠ½Π°ΡΡΡΡ
. ΠΠΎΡΡΠΊ ΠΎΠ±ΠΌΠ΅ΠΆΡΠ²Π°Π²ΡΡ
ΡΠ΅ΡΠ΅Π½Π·ΠΎΠ²Π°Π½ΠΈΠΌΠΈ ΡΡΠ°ΡΡΡΠΌΠΈ, ΠΎΠΏΡΠ±Π»ΡΠΊΠΎΠ²Π°Π½ΠΈΠΌΠΈ Π² ΠΏΠ΅ΡΡΠΎΠ΄ ΡΠ·
ΡΡΡΠ½Ρ 2012 ΡΠΎΠΊΡ Π΄ΠΎ ΡΡΡΠ½Ρ 2022 ΡΠΎΠΊΡ.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ. ΠΠ½Π°Π»ΡΠ· Π½Π°ΡΠΊΠΎΠ²ΠΎΡ Π»ΡΡΠ΅ΡΠ°ΡΡΡΠΈ
ΠΏΠΎΠΊΠ°Π·Π°Π², ΡΠΎ Π΄Π»Ρ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π·Π°ΠΏΠ°Π»ΡΠ½ΠΈΡ
Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Ρ
ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠ° Π²ΠΈΠΊΠΎΡΠΈΡΡΠΎΠ²ΡΡΡΡΡΡ Π²Π΅Π»ΠΈΠΊΠ° ΠΊΡΠ»ΡΠΊΡΡΡΡ
Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
ΡΠΎΡΠ»ΠΈΠ½ ΡΠ° ΡΠΎΡΠ»ΠΈΠ½Π½ΠΎΡ ΡΠΈΡΠΎΠ²ΠΈΠ½ΠΈ, ΡΠ΅ΡΠ΅Π΄ ΡΠΊΠΈΡ
Aloe vera, Calendula officinalis, Magnolia officinalis,
Salvia officinalis, Rosmarinus officinalis, Punica granatum
Azadirachta indica, Glycyrrhiza glabra, Cinnamomum
zeylanicum, Allium sativum, Propolis, Mikania laevigata,
Mikania glomerate, Droserapeltata, Helichrysum
italicum, Coptidis rhizome, Piper cubeba, Azadirachta
indica, Syzygium Aromaticum, Π΅ΠΊΡΡΡΠ°ΠΊΡΠΈ ΡΠΊΠΈΡ
ΡΠΈΠ½ΡΡΡ
Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΡΠ°Π»ΡΠ½ΠΈΠΉ, ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½ΠΈΠΉ, Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΈΠΉ
Π΅ΡΠ΅ΠΊΡ,Π·ΠΌΠ΅Π½ΡΡΡΡΡ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ Π·ΡΠ±Π½ΠΎΠ³ΠΎ Π½Π°Π»ΡΠΎΡΡ,
Π·ΠΌΠ΅Π½ΡΡΡΡΡ ΠΏΡΠΎΡΠ²ΠΈ ΠΊΡΠΎΠ²ΠΎΡΠΎΡΠΈΠ²ΠΎΡΡΡ ΡΡΠ΅Π½.
ΠΠΈΡΠ½ΠΎΠ²ΠΎΠΊ. Π€ΡΡΠΎΡΠ΅ΡΠ°ΠΏΡΡ Ρ ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½ΠΎ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΈΠΌ
ΠΊΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠΎΠΌ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
Π·Π°ΡΠΎΠ±ΡΠ² ΡΠ°
ΠΌΠΎΠΆΠ΅ Π±ΡΡΠΈ Π·Π°ΡΡΠΎΡΠΎΠ²Π°Π½Π° ΡΠΊ Π΄ΠΎΠΏΠΎΠ²Π½Π΅Π½Π½Ρ Π΄ΠΎ ΠΏΡΠΎΡΠ΅Π΄ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΉΠ½ΠΎΡ Π³ΡΠ³ΡΡΠ½ΠΈ ΠΏΠΎΡΠΎΠΆΠ½ΠΈΠ½ΠΈ ΡΠΎΡΠ° Π² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΌΡ
Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π·Π°ΠΏΠ°Π»ΡΠ½ΠΈΡ
Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Ρ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠ°.One of the urgent problems of modern dentistry is
inflammatory periodontal disease. In recent decades, there
has been a negative trend in the spread of inflammatory
periodontal disease among people of working age. In the
complex treatment of inflammatory periodontal diseases,
synthetic drugs are used, which have a large number of
side effects. Therefore, one of the areas of search for new
drugs is the analysis of medicinal plants and raw materials
containing biologically active substances that can affect
various links in the pathogenesis of inflammation in
periodontal tissues and can be used in the treatment of
gingivitis and periodontitis.
The aim of the study was to analyze the features of the
use of medicinal plants, medicinal plant raw materials
and phytopreparations in the complex treatment of
inflammatory periodontal diseases and to conduct an
analytical search of medicinal plants and medicinal
plant raw materials to create new drugs for further use in
periodontology.
Materials and methods. The study was designed
retrospectively using the Google Scholar search engine
(https://scholar.google.com/) and the PubMed database
(https://pubmed.ncbi.nlm.nih.gov/) using the appropriate
keywords: " medicinal plantsΒ», Β«dentistryΒ», Β«periodontitisΒ»,
Β«gingivitisΒ», Β«oral bacteriaΒ», Β«porphyromonas gingivalisΒ»
in various combinations. The search was limited to peerreviewed articles published between January 2012 and
January 2022.
Results. The analysis of the scientific literature showed that
a large number of medicinal plants and plant raw materials
are used for the treatment of inflammatory periodontal
diseases, including Aloe vera, Calendula officinalis,
Magnolia officinalis, Salvia officinalis, Rosmarinus
officinalis, Punica granatum Azadirachta indica,
Glycyrrhiza glabra, Cinnamomum zeylanicum, Allium
sativum, Propolis, Mikania laevigata, Mikania glomerate,
Droserapeltata, Helichrysum italicum, Coptidis rhizome,
Piper cubeba, Azadirachta indica, Syzygium Aromaticum,
extracts of which have antibacterial, anti-inflammatory,
antioxidant effect, reduce the formation of plaque, reduce
the manifestations of bleeding gums.
Conclusions. Phytotherapy is a potentially effective
competitor of synthesized drugs and can be used as an
adjunct to the procedures of professional oral hygiene
in the complex treatment of inflammatory periodontal
diseases
Bronchial with plantain, thyme and vitamin Π‘ β herbal preparation of choice for complex treatment of upper airwaysβ inflammatory diseases
Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΡΠ»Π° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠΈΡΠΎΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΡΠΎΠ½Ρ
ΠΈΠ°Π» Ρ ΠΏΠΎΠ΄ΠΎΡΠΎΠΆΠ½ΠΈΠΊΠΎΠΌ, ΡΠ°Π±ΡΠ΅ΡΠΎΠΌ ΠΈ Π²ΠΈΡΠ°ΠΌΠΈΠ½ΠΎΠΌ Π‘ Π² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΌ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π²Π΅ΡΡ
Π½ΠΈΡ
Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΡΠΈΡΠΎΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΡΠ»ΡΡΡΠ°Π΅Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΠΊΠ°ΡΡΠΈΠ½Ρ ΠΈ ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΡ
ΡΡ
Π΅ΠΌ Π»Π΅ΡΠ΅Π½ΠΈΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π²Π΅ΡΡ
Π½ΠΈΡ
Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ.ΠΠ΅ΡΠΎΡ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ Π±ΡΠ»Π° ΠΊΠ»ΡΠ½ΡΡΠ½Π° ΠΎΡΡΠ½ΠΊΠ° Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ ΡΡΡΠΎΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ ΠΡΠΎΠ½Ρ
ΡΠΎΠ» Π· ΠΏΠΎΠ΄ΠΎΡΠΎΠΆΠ½ΠΈΠΊΠΎΠΌ, ΡΠ΅Π±ΡΠ΅ΡΠ΅ΠΌ Ρ Π²ΡΡΠ°ΠΌΡΠ½ΠΎΠΌ Π‘ Ρ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΌΡ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π·Π°ΠΏΠ°Π»ΡΠ½ΠΈΡ
Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Ρ Π²Π΅ΡΡ
Π½ΡΡ
Π΄ΠΈΡ
Π°Π»ΡΠ½ΠΈΡ
ΡΠ»ΡΡ
ΡΠ². ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ Π΄Π°Π½ΠΎΠ³ΠΎ ΡΡΡΠΎΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ ΠΏΠΎΠΊΡΠ°ΡΡΡ ΠΊΠ»ΡΠ½ΡΡΠ½Ρ ΠΊΠ°ΡΡΠΈΠ½Ρ Ρ ΠΏΠΎΡΠΈΠ»ΡΡ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡΡΡ Ρ Π±Π΅Π·ΠΏΠ΅ΠΊΡ ΡΡΠ°Π΄ΠΈΡΡΠΉΠ½ΠΈΡ
ΡΡ
Π΅ΠΌ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π·Π°ΠΏΠ°Π»ΡΠ½ΠΈΡ
Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Ρ Π²Π΅ΡΡ
Π½ΡΡ
Π΄ΠΈΡ
Π°Π»ΡΠ½ΠΈΡ
ΡΠ»ΡΡ
ΡΠ².The purpose of researches was clinical rating of effectiveness of use of herbal preparation Bronchial with plantain, thyme and vitamin C for complex treatment of upper airwaysβ inflammatory diseases. It is established , that the use of this herbal preparation improves a clinical picture and raises effectiveness and safety of traditional schemes of treatment of upper airwaysβ inflammatory
diseases
ΠΠΠ‘ΠΠΠΠΠΠΠΠ― ΠΠ ΠΠ’ΠΠΠΠΠΠΠ¬ΠΠΠ ΠΠΠ’ΠΠΠΠΠ‘Π’Π ΠΠ‘Π’ΠΠ ΠΠ ΠΠΠ£ΠΠ ΠΠ€ΠΠΠ£ Π ΠΠΠΠΠΠΠΠΠ Π ΠΠΠΠ¬ΠΠΠ§ΠΠ‘Π’ΠΠ’ΠΠΠ Π£ΠΠ¬Π’Π ΠΠΠΠ£ΠΠΠ ΠΠ ΠΠΠΠΠΠ ΠΠΠ ΠΠΠΠΠΠ-ΠΠΠΠ£ΠΠΠΠΠΠΠΠ ΠΠΠΠΠΠΠΠΠ―
The aim of the work. Study of the anti-inflammatory activity of the ointment with ibuprofen esters in combination with low-frequency ultrasound.
Materials and Methods. The anti-inflammatory effect of the synthesized compounds was evaluated in a model of carrageenan inflammation by subplantar injection of a carrageenan solution into the hind limb of rats. Low-frequency ultrasound with a frequency of 20-25 kHz was used to enhance skin permeability. The study used white male Wistar rats weighing 180β220 g. The dynamics of changes in the inflammatory process was determined by measuring the thickness and volume of the affected limbs. A 5 % ibuprofen ointment "Dolgit cream" was used as a reference drug. Statistical indicators were calculated using the Microsoft Excel software package.
Results and Discussion. According to the results of the study of the volume of the affected limbs, it was found that starting from the 4th day of treatment, ibuprofen ethyl ester in combination with low-frequency ultrasound demonstrates better anti-inflammatory activity than the reference drug. A similar trend is observed when determining the thickness of the affected limb. Πn the group treated with ibuprofen ethyl ether, the thickness of the affected limbs reaches the physiological norm on the 6th day of treatment, while in the group treated with ibuprofen hexadecyl ether β on the 7th day.
Conclusions. The results obtained indicate that the use of synthesized ibuprofen esters in combination with low-frequency ultrasound leads to an increase in their anti-inflammatory activity. The best dynamics of anti-inflammatory activity is inherent in ibuprofen ethyl ester.ΠΠ΅ΡΠ° ΡΠΎΠ±ΠΎΡΠΈ. ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΌβΡΠΊΠΎΡ Π»ΡΠΊΠ°ΡΡΡΠΊΠΎΡ ΡΠΎΡΠΌΠΈ Π· Π΅ΡΡΠ΅ΡΠ°ΠΌΠΈ ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½Ρ Π² ΠΏΠΎΡΠ΄Π½Π°Π½Π½Ρ Π· Π½ΠΈΠ·ΡΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΠΈΠΌ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠΌ.
ΠΠ°ΡΠ΅ΡΡΠ°Π»ΠΈ Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈ. Β ΠΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½Ρ Π΄ΡΡ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ ΠΎΡΡΠ½ΡΠ²Π°Π»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΡΒ ΠΊΠ°ΡΠ°Π³Π΅Π½ΡΠ½ΠΎΠ²ΠΎΠ³ΠΎ Π·Π°ΠΏΠ°Π»Π΅Π½Π½Ρ ΡΠ»ΡΡ
ΠΎΠΌ ΡΡΠ±ΠΏΠ»Π°Π½ΡΠ°ΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½Π½Ρ ΡΠΎΠ·ΡΠΈΠ½Ρ ΠΊΠ°ΡΠ°Π³Π΅Π½ΡΠ½Ρ Π² Π·Π°Π΄Π½Ρ ΠΊΡΠ½ΡΡΠ²ΠΊΡ ΡΡΡΡΠ². ΠΠ»Ρ ΠΏΠΎΡΠΈΠ»Π΅Π½Π½Ρ ΠΏΡΠΎΠ½ΠΈΠΊΠ½ΠΎΡΡΡ ΡΠΊΡΡΠΈ Π²ΠΈΠΊΠΎΡΠΈΡΡΠΎΠ²ΡΠ²Π°Π»ΠΈ Π½ΠΈΠ·ΡΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΠΈΠΉ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊ ΡΠ· ΡΠ°ΡΡΠΎΡΠΎΡ 20β25 ΠΊΠΡ. Π£ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ Π±ΡΠ»ΠΈ Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Π½Ρ Π±ΡΠ»Ρ ΡΡΡΠΈ-ΡΠ°ΠΌΡΡ Π»ΡΠ½ΡΡ ΠΡΡΡΠ°Ρ ΠΌΠ°ΡΠΎΡ 180β220 Π³. ΠΠΈΠ½Π°ΠΌΡΠΊΡ Π·ΠΌΡΠ½ΠΈ Π·Π°ΠΏΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡ Π²ΠΈΠ·Π½Π°ΡΠ°Π»ΠΈ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ Π²ΠΈΠΌΡΡΡ ΡΠΎΠ²ΡΠΈΠ½ΠΈ ΡΠ° ΠΎΠ±βΡΠΌΡ ΡΡΠ°ΠΆΠ΅Π½ΠΈΡ
ΠΊΡΠ½ΡΡΠ²ΠΎΠΊ. Π―ΠΊ ΡΠ΅ΡΠ΅ΡΠ΅Π½Ρ-ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ Π²ΠΈΠΊΠΎΡΠΈΡΡΠΎΠ²ΡΠ²Π°Π»ΠΈ 5 % ΠΌΠ°Π·Ρ ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½Ρ Β«ΠΠΎΠ»Π³ΡΡ ΠΊΡΠ΅ΠΌΒ». Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ½Ρ ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠΈ Π²ΠΈΡΠ°Ρ
ΠΎΠ²ΡΠ²Π°Π»ΠΈ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠ½ΠΎΠ³ΠΎ ΠΏΠ°ΠΊΠ΅ΡΠ° Microsoft Excel.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈΒ ΠΉΒ ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. ΠΠ° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌΠΈ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ ΠΎΠ±βΡΠΌΡ ΡΡΠ°ΠΆΠ΅Π½ΠΈΡ
ΠΊΡΠ½ΡΡΠ²ΠΎΠΊ Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ Π²ΡΠ΄ ΠΏΠΎΡΠ°ΡΠΊΡ 4-Ρ Π΄ΠΎΠ±ΠΈ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π΅ΡΠΈΠ»ΠΎΠ²ΠΈΠΉ Π΅ΡΡΠ΅Ρ ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½Ρ Π² ΠΏΠΎΡΠ΄Π½Π°Π½Π½Ρ Π· Π½ΠΈΠ·ΡΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΠΈΠΌ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠΌ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΡΡ ΠΊΡΠ°ΡΡ ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ, Π½ΡΠΆ ΡΠ΅ΡΠ΅ΡΠ΅Π½Ρ-ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ. ΠΠ½Π°Π»ΠΎΠ³ΡΡΠ½Π° ΡΠ΅Π½Π΄Π΅Π½ΡΡΡ ΡΠΏΠΎΡΡΠ΅ΡΡΠ³Π°ΡΡΡΡΡ ΠΏΡΠΈ Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ ΡΠΎΠ²ΡΠΈΠ½ΠΈ ΡΡΠ°ΠΆΠ΅Π½ΠΎΡ ΠΊΡΠ½ΡΡΠ²ΠΊΠΈ. Π’Π°ΠΊ, Ρ Π³ΡΡΠΏΡ ΡΠ²Π°ΡΠΈΠ½, ΡΠΊΠΈΡ
Π»ΡΠΊΡΠ²Π°Π»ΠΈ Π΅ΡΠΈΠ»ΠΎΠ²ΠΈΠΌ Π΅ΡΡΠ΅ΡΠΎΠΌ ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½Ρ, ΡΠΎΠ²ΡΠΈΠ½Π° ΡΡΠ°ΠΆΠ΅Π½ΠΈΡ
ΠΊΡΠ½ΡΡΠ²ΠΎΠΊ Π΄ΠΎΡΡΠ³Π°Ρ ΠΌΠ΅ΠΆ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ Π½ΠΎΡΠΌΠΈ Π½Π° 6-ΠΉ Π΄Π΅Π½Ρ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ, ΡΠΎΠ΄Ρ ΡΠΊ Ρ Π³ΡΡΠΏΡ ΡΠ²Π°ΡΠΈΠ½, Π»ΡΠΊΠΎΠ²Π°Π½ΠΈΡ
Π³Π΅ΠΊΡΠ°Π΄Π΅ΡΠΈΠ»ΠΎΠ²ΠΈΠΌ Π΅ΡΡΠ΅ΡΠΎΠΌ ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½Ρ β Π½Π° 7-ΠΉ Π΄Π΅Π½Ρ.
ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΡΡΠΈΠΌΠ°Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ²ΡΠ΄ΡΠ°ΡΡ ΠΏΡΠΎ ΡΠ΅, ΡΠΎ Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Π½Ρ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
Π΅ΡΡΠ΅ΡΡΠ²Β ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½Ρ Π² ΠΏΠΎΡΠ΄Π½Π°Π½Π½Ρ Π· Π½ΠΈΠ·ΡΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΠΈΠΌ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠΌ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡΡ Π΄ΠΎ ΠΏΡΠ΄Π²ΠΈΡΠ΅Π½Π½Ρ ΡΡ
Π½ΡΠΎΡ ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ. ΠΠ°ΠΆΠ»ΠΈΠ²ΠΎ Π·Π°Π·Π½Π°ΡΠΈΡΠΈ, ΡΠΎ Π²ΠΈΡΠ° ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½Π° Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΏΡΠΈΡΠ°ΠΌΠ°Π½Π½Π° ΡΠ°ΠΌΠ΅ Π΅ΡΠΈΠ»ΠΎΠ²ΠΎΠΌΡ Π΅ΡΡΠ΅ΡΡ ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½Ρ
The influence of chronic stress on virusinducted interferon production in animals of different age
ΠΠΈΠ²ΡΠ°Π»ΠΈ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ ΡΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½ΠΎΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ Ρ ΡΡΠ°ΡΠ΅Π²ΠΎΠ·ΡΡΠ»ΠΈΡ
Ρ ΡΡΠ°ΡΠΈΡ
ΠΌΠΈΡΠ΅ΠΉ, Π·Π°ΡΠ°ΠΆΠ΅Π½ΠΈΡ
ΡΡΠ±Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΡ Π΄ΠΎΠ·ΠΎΡ Π²ΡΡΡΡΡ Π³ΡΠΈΠΏΡ Π Π½Π° ΡΡΠ·Π½ΠΈΡ
Π΅ΡΠ°ΠΏΠ°Ρ
ΡΠΎΡΠΌΡΠ²Π°Π½Π½Ρ ΡΡΡΠ΅Ρ-ΡΠΈΠ½Π΄ΡΠΎΠΌΡ. ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ Ρ
ΡΠΎΠ½ΡΡΠ½ΠΈΠΉ ΡΡΡΠ΅Ρ Π½Π° ΠΏΠΎΡΠ°ΡΠΊΠΎΠ²ΠΈΡ
Π΅ΡΠ°ΠΏΠ°Ρ
Π΄ΠΎΠ΄Π°ΡΠΊΠΎΠ²ΠΎ ΡΡΠΈΠΌΡΠ»ΡΡ Π²ΡΡΡΡΡΠ½Π΄ΡΠΊΠΎΠ²Π°Π½Π΅ ΡΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½ΠΎΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ Ρ ΡΡΠ°ΡΠ΅Π²ΠΎΠ·ΡΡΠ»ΠΈΡ
ΠΌΠΈΡΠ΅ΠΉ, ΠΏΡΠ΄Π²ΠΈΡΡΡΡΠΈ ΡΡ
ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡΡΡ
Π΄ΠΎ ΡΡΠ±Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΡ Π²ΡΡΡΡΠ½ΠΎΡ ΡΠ½ΡΠ΅ΠΊΡΡΡ, ΡΠΈΠΌΡΠ°ΡΠΎΠΌ ΡΠΊ Ρ ΡΡΠ°ΡΠΈΡ
ΠΌΠΈΡΠ΅ΠΉ β Π½Π°Π²ΠΏΠ°ΠΊΠΈ, ΡΠΏΠΎΡΡΠ΅ΡΡΠ³Π°ΡΡΡΡΡ ΠΏΡΠΈΠ³Π½ΡΡΠ΅Π½Π½Ρ ΡΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½ΠΎΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ, ΠΏΠΎΡΠΈΠ½Π°ΡΡΠΈ Π²ΠΆΠ΅ Π· ΠΏΠ΅ΡΡΠΎΡ Π΄ΠΎΠ±ΠΈ ΡΡΡΠ΅ΡΡ, ΡΠΎΠ±ΡΠΎ ΡΡΠ°Π΄ΡΡ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡ ΡΡΡΠ΅ΡΡ, Π· Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎΡ Π΄Π»Ρ ΡΡΠ°ΡΠ΅Π²ΠΎΠ·ΡΡΠ»ΠΈΡ
ΠΌΠΈΡΠ΅ΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΡΡΡ ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΡΠ² ΠΏΡΠΎΡΠΈΠ²ΡΡΡΡΠ½ΠΎΠ³ΠΎ Π·Π°Ρ
ΠΈΡΡΡ, Ρ
ΡΡΠ°ΡΠΈΡ
ΡΠ²Π°ΡΠΈΠ½ Π²ΡΠ΄ΡΡΡΠ½Ρ. Π₯ΡΠΎΠ½ΡΡΠ½ΠΈΠΉ 4-Π΄ΠΎΠ±ΠΎΠ²ΠΈΠΉ ΡΡΡΠ΅Ρ ΠΏΡΠΈΠ·Π²ΠΎΠ΄ΠΈΡΡ Π΄ΠΎ ΠΏΠΎΠ²Π½ΠΎΠ³ΠΎ Π²ΠΈΡΠ½Π°ΠΆΠ΅Π½Π½Ρ ΠΏΡΠΈΡΠΎΠ΄Π½ΠΈΡ
ΡΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π·Π°Π»Π΅ΠΆΠ½ΠΈΡ
ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΡΠ² Π·Π°Ρ
ΠΈΡΡΡ, ΡΠΏΡΠΈΡΡΡΠΈ Π³Π΅Π½Π΅ΡΠ°Π»ΡΠ·Π°ΡΡΡ Π²ΡΡΡΡΠ½ΠΎΡ
ΡΠ½ΡΠ΅ΠΊΡΡΡ ΡΠ° ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄Ρ ΡΡΠ±Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΡ Π΄ΠΎΠ·ΠΈ Π²ΡΡΡΡΡ Π³ΡΠΈΠΏΡ Π² Π»Π΅ΡΠ°Π»ΡΠ½Ρ. Π£ ΡΡΠ°ΡΠΈΡ
ΡΠ²Π°ΡΠΈΠ½ ΡΡ ΠΏΠΎΡΡΡΠ΅Π½Π½Ρ Π±ΡΠ»ΡΡ Π³Π»ΠΈΠ±ΠΎΠΊΡ ΠΉ ΡΠΎΠ·Π²ΠΈΠ²Π°ΡΡΡΡΡ Π²ΠΆΠ΅ Π½Π° ΡΠ°Π½Π½ΡΡ
Π΅ΡΠ°ΠΏΠ°Ρ
Ρ
ΡΠΎΠ½ΡΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡ.It was studied interferonogenesis in adult and old mice,
infected by sublethal dose of grippe A virus in different stage
of stress-syndrome. It was established that chronic stress in
early stage stimulated virusinduced interferonogenesis in
adult mice and increased its resistance to sublethal viral infection. In old mice we observed depression of interferonogenesis after the first day of experimental old mice didnβt
demonstrate the resistance stage of stress-syndrome with increasing of antiviral activity. A chronic 4-day stress leads
to global depression of antiviral activity and generalization
of viral infection, transforms a sublethal dose to a lethal one.
Old animals had more expressive changes of antiviral activity at the early stage of a chronic stress-syndrome
ΠΠΈΠ²ΡΠ΅Π½Π½Ρ ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½ΠΈΡ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΠ΅ΠΉ Π΅ΡΡΠ΅ΡΡΠ² ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½Ρ Π² ΠΏΠΎΡΠ΄Π½Π°Π½Π½Ρ Π· Π΅ΠΊΡΡΡΠ°ΠΊΡΠΎΠΌ Π³ΡΡΠΊΠΎΠ³ΠΎ ΠΏΠ΅ΡΡΡ Π· ΠΌΠ΅ΡΠΎΡ ΠΏΠΎΡΠΈΠ»Π΅Π½Π½Ρ ΠΊΡΡΠ·ΡΡΠΊΡΡΠ½ΠΎΡ ΠΏΡΠΎΠ½ΠΈΠΊΠ½ΠΎΡΡΡ
ΠΠ΄Π½ΡΡΡ Π· ΠΏΡΠΎΠ±Π»Π΅ΠΌ ΡΡΡΠ°ΡΠ½ΠΎΡ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΡΡ Ρ ΠΏΡΠ΄Π²ΠΈΡΠ΅Π½Π½Ρ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Ρ, ΡΠΎ ΡΡΠΏΡΠΎΠ²ΠΎΠ΄ΠΆΡΡΡΡΡΡ ΡΠΎΠ·Π²ΠΈΡΠΊΠΎΠΌ Π·Π°ΠΏΠ°Π»Π΅Π½Π½Ρ. ΠΠ°ΠΏΡΠ°ΡΡΠΈΠ½, ΡΠΊΠΈΠΉ ΠΌΡΡΡΠΈΡΡΡΡ Π² Π΅ΠΊΡΡΡΠ°ΠΊΡΡ Π³ΡΡΠΊΠΎΠ³ΠΎ ΠΏΠ΅ΡΡΡ (Capsicum annuum), Π²ΡΠ΄Π½ΠΎΡΡΡΡ Π΄ΠΎ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ Π³ΡΡΠΏΠΈ Β«ΠΠΎΠ΄ΡΠ°Π·Π½ΡΡΡΡ ΡΠ΅ΡΠΎΠ²ΠΈΠ½ΠΈ ΠΏΡΠΈΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΠΎΡ
ΠΎΠ΄ΠΆΠ΅Π½Π½ΡΒ». ΠΠΎΠ΄ΡΠ°Π·Π½ΡΠ²Π°Π»ΡΠ½Π° Π΄ΡΡ ΡΠ° Π±ΠΎΠ»Π΅Π·Π°ΡΠΏΠΎΠΊΡΠΉΠ»ΠΈΠ²ΠΈΠΉ Π΅ΡΠ΅ΠΊΡ ΠΎΠ±ΡΠΌΠΎΠ²Π»Π΅Π½Ρ Π²ΠΏΠ»ΠΈΠ²ΠΎΠΌ ΠΊΠ°ΠΏΡΠ°ΡΡΠΈΠ½Ρ Π½Π° Π²Π°Π½ΡΠ»ΠΎΡΠ΄Π½Ρ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΈ VR1,
Π²ΡΠ½ Ρ ΡΡ
Π°Π³ΠΎΠ½ΡΡΡΠΎΠΌ. ΠΠΎ Π½Π°ΠΉΡΠ°ΡΡΡΡΠ΅ Π²ΠΆΠΈΠ²Π°Π½ΠΈΡ
Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡΠ² Ρ ΠΌΠ΅Π΄ΠΈΡΠ½ΡΠΉ ΠΏΡΠ°ΠΊΡΠΈΡΡ Π½Π°Π»Π΅ΠΆΠ°ΡΡ Π½Π΅ΡΡΠ΅ΡΠΎΡΠ΄Π½Ρ ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½Ρ Π·Π°ΡΠΎΠ±ΠΈ, ΠΎΠ΄Π½ΠΈΠΌ Π· ΡΠΊΠΈΡ
Ρ ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½. ΠΡΠΎΡΠ΅ ΡΡΡΠ°ΡΠ½Ρ ΠΌΠ°Π·Π΅Π²Ρ ΡΠΎΡΠΌΠΈ ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½Ρ Π½Π΅ Π²ΠΎΠ»ΠΎΠ΄ΡΡΡΡ Π΄ΠΎΡΡΠ°ΡΠ½ΡΠΎΡ Π½Π°Π΄ΡΠΊΡΡΠ½ΠΎΡ ΠΏΡΠΎΠ½ΠΈΠΊΠ½ΡΡΡΡ. ΠΠ΅ΡΠΎΡ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π±ΡΠ»ΠΎ ΠΏΠΎΡΡΠ²Π½ΡΡΠΈ ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½Ρ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡ ΠΌΠ°Π·Π΅Π²ΠΈΡ
ΡΠΎΡΠΌ ΡΡΠ·Π½ΠΈΡ
Π·Π° Π΄ΠΎΠ²ΠΆΠΈΠ½ΠΎΡ Π΅ΡΡΠ΅ΡΡΠ² ΡΠ±ΡΠΏΡΠΎΡΠ΅Π½Ρ Π· Π΅ΠΊΡΡΡΠ°ΠΊΡΠΎΠΌ Π³ΡΡΠΊΠΎΠ³ΠΎ ΠΏΠ΅ΡΡΡ, ΡΡΠ°Π½Π΄Π°ΡΡΠΈΠ·ΠΎΠ²Π°Π½ΠΈΠΌ Π·Π° Π²ΠΌΡΡΡΠΎΠΌ ΠΊΠ°ΠΏΡΠ°ΡΡΠΈΠ½Ρ
Peculiarities of complex use of rhodiola rosea phytodrug and diazepam under conditions of the experimental stress immunosupression
ΠΠ΅ΡΠ° Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ ΠΏΠΎΠ»ΡΠ³Π°Π»Π° Π·'ΡΡΡΠ²Π°Π½Π½Ρ ΡΡΠ°ΡΡΡ ΡΠΈΡΠΎΠΊΡΠ½Π·Π°Π»Π΅ΠΆΠ½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ² Ρ ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΠ°Ρ
ΡΠΌΡΠ½ΠΎΡΡΠΎΠΏΠ½ΠΎΡ Π΄ΡΡ Π΄ΡΠ°Π·Π΅ΠΏΠ°ΠΌΡ ΡΠ° Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ ΠΌΠΎΠΆΠ»ΠΈΠ²ΠΎΡΡΠ΅ΠΉ ΠΊΠΎΡΠ΅ΠΊΡΡΡ Π²ΠΈΡΠ²Π»Π΅Π½ΠΈΡ
ΠΏΠΎΡΡΡΠ΅Π½Ρ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ ΡΠΎΠ΄ΡΠΎΠ»ΠΈ ΡΠΎΠΆΠ΅Π²ΠΎΡ. Π£ Π΄ΠΎΡΠ»ΡΠ΄Π°Ρ
Π½Π° ΡΡΡΠ°Ρ
Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ ΡΡΡΠ΅ΡΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠ½Ρ ΡΠ° ΡΠΌΡΠ½ΠΎΡΡΠΎΠΏΠ½Ρ Π΅ΡΠ΅ΠΊΡΠΈ Π΄ΡΠ°Π·Π΅ΠΏΠ°ΠΌΡ (2 ΠΌΠ³ / ΠΊΠ³, Π² / ΠΎΡΠ΅ΡΠ΅Π²ΠΈΠ½Π½ΠΎ) Π² ΡΠΌΠΎΠ²Π°Ρ
Ρ
ΡΠΎΠ½ΡΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡ Π½Π΅ ΠΏΠΎΠ²'ΡΠ·Π°Π½Ρ Π· ΠΊΠΎΡΠ΅ΠΊΡΡΡΡ ΠΊΠ»ΡΡΠΈΠ½Π½ΠΎ-ΡΠΈΡΠΎΠΊΡΠ½ΠΈΡ
Π²Π·Π°ΡΠΌΠΎΠ²ΡΠ΄Π½ΠΎΡΠΈΠ½. ΠΠΎΠ²Π΅Π΄Π΅Π½ΠΎ, ΡΠΎ Π² ΡΠΌΠΎΠ²Π°Ρ
Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΡ ΡΡΡΠ΅ΡΠΎΠ²ΠΎΡ ΡΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΡ, Π²ΡΠ΄ΡΠ²ΠΎΡΠ΅Π½ΠΎΡ ΡΠ»ΡΡ
ΠΎΠΌ 4-Π΄ΠΎΠ±ΠΎΠ²ΠΎΡ Π΄Π΅ΠΏΡΠΈΠ²Π°ΡΡΡ ΡΠ½Ρ, Π³Π°Π»Π΅Π½ΠΎΠ²ΠΈΠΉ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΊΠΎΡΠ΅Π½Ρ ΡΠΎΠ΄ΡΠΎΠ»ΠΈ ΡΠΎΠΆΠ΅Π²ΠΎΡ, ΡΠΊΠΈΠΉ Π²Π²ΠΎΠ΄ΠΈΠ²ΡΡ ΠΏΡΠΎΡΡΠ³ΠΎΠΌ 10 Π΄ΡΠ± ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ Π² Π΄ΠΎΠ·Ρ 1 Π³ / ΠΊΠ³ Π΄ΠΎ Π²ΡΠ΄ΡΠ²ΠΎΡΠ΅Π½Π½Ρ ΡΡΡΠ΅ΡΡ, Π½Π΅ Π·ΠΌΠ΅Π½ΡΡΡ ΡΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡ, Π°Π»Π΅ ΡΠΊΠΎΡΠΎΡΡΡ ΡΡΠΈΠ²Π°Π»ΡΡΡΡ ΡΠ½Π΄ΡΠΊΠΎΠ²Π°Π½ΠΎΡ ΡΡΡΠ΅ΡΠΎΠΌ ΠΏΡΠΎΠ΄ΡΠΊΡΡΡ ΠΊΠΎΡΡΠΈΠΊΠΎΡΡΠ΅ΡΠΎΠ½Ρ, Π²ΡΠ΄Π½ΠΎΠ²Π»ΡΡ ΡΡΠ½ΠΊΡΡΠΎΠ½Π°Π»ΡΠ½ΠΈΠΉ ΡΠ΅Π·Π΅ΡΠ² ΠΏΡΠΎΠ΄ΡΠΊΡΡΡ Π»ΡΠΌΡΠΎΡΠΈΡΠ°ΠΊΡΠΈΠ²ΡΡΡΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ°, ΠΏΡΠ΄Π²ΠΈΡΡΡ ΡΡΡΠ»ΠΈΠ²ΡΡΡΡ Π»ΡΠΌΡΠΎΡΠΈΡΡΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ½ΠΎΡ ΠΊΡΠΎΠ²Ρ ΡΡΡΡΠ² Π΄ΠΎ ΠΊΠΎΠΌΡΡΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Π²ΠΏΠ»ΠΈΠ²Ρ ΡΠΈΡΠΎΠΊΡΠ½ΡΠ², ΡΠΏΡΠΈΡΡΠΈΠ½Π°ΡΡΠΈ ΡΠΈΠΌ ΡΠ°ΠΌΠΈΠΌ Π·Π°Ρ
ΠΈΡΠ½ΠΈΠΉ Π²ΠΏΠ»ΠΈΠ² Π½Π° ΡΠ½ΡΠ΅Π³ΡΠ°Π»ΡΠ½Ρ ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠΈ Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΌΡΠ½ΡΡΠ΅ΡΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΠΎ ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½Π΅ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ ΡΡΡΠΎΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ ΡΠΎΠ΄ΡΠΎΠ»ΠΈ ΡΠΎΠΆΠ΅Π²ΠΎΡ Ρ Π΄ΡΠ°Π·Π΅ΠΏΠ°ΠΌΡ Π½Π°ΠΉΠ±ΡΠ»ΡΡ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΡΡΡΠ²Π°Ρ ΡΡΡΠ΅ΡΠΎΠ²Ρ ΡΠΎΠ·Π»Π°Π΄ΠΈ Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΌΡΠ½ΡΡΠ΅ΡΡ Π·Π° ΡΠ°Ρ
ΡΠ½ΠΎΠΊ ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΠΏΠ»ΠΈΠ²Ρ Π½Π° ΡΡΠ·Π½Ρ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ½Ρ ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΠΈ ΡΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΡ.The aim of the research was to reveal the participation of cytokine-depend processes in the mechanisms of the immunotropic action of diazepam and to study the possibilities of correction of disorders found by Rhodi-ola rosea. It has been found in experiments with rats was that stress-protective and immuno-modulating effects of diazepam (2 mg/kg, peritoneally) under conditions of the chronic stress are not associated with the correction of cell-cytokine relationships. It has been proven that under the experimental stress immunosuppression, which was reproduced by 4 day sleep deprivation, a galenic drug from Rhodiola rosea root introduced orally in the dose of lg/kg for 10 days before reproducing the stress does not reduce the intensity, but decreases the duration of corticosterone production induced by the stress, restores the functional reserve of lymphocyte-activating factor production, increases the sensitivity of peripheral blood lymphocytes of rats to the comitogenic influence of cytokines, thereby causing the protective effect on integrated indicators of the humoral immunity. It has been shown that the combined use of Rhodiola rosea phytodrug and diazepam eliminates stress disorders of the humoral immunity more effectively due to the positive influence on different pathogenic mechanisms of immunosupression
The Element Composition Study of Thick Extract from Tribulus terrestris L. Herb
The element composition of thick extract from caltrop herb was studied by the atom-emission spectroscopic method. The content of 19 elements was determined. Potassium, sodium and calcium dominated among the mineral elements. The content of heavy metals did not exceed the permissible limits. The purpose of work was a study of prostrate caltrop herb thick extract element composition
Comparative effects of immunomodulators on the factors of antiinfection immunity in doxorubicin-induced immunosuppressive model
Π ΠΎΠΏΡΡΠ°Ρ
Π½Π° ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΈΠ·ΡΡΠ°Π»ΠΈ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠΌΠΎΠ΄ΡΠ»ΡΡΠΎΡΠΎΠ² Π°ΠΌΠΈΠΊΡΠΈΠ½Π°, ΠΈΠΌΡΠ½ΠΎΡΠ°Π½Π° ΠΈ ΠΏΠΎΠ»ΠΈΠΎΠΊΡΠΈΠ΄ΠΎΠ½ΠΈΡ Π½Π° ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΏΡΠΎΡΠΈΠ²ΠΎΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠΈ, ΠΊΠΎΡΠΎΡΠ°Ρ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΠΏΡΡΠ΅ΠΌ 4-ΡΠ°Π·ΠΎΠ²ΠΎΠ³ΠΎ Π΅ΠΆΠ΅Π½Π΅Π΄Π΅Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½Π° Π² Π΄ΠΎΠ·Π΅ 5,0 ΠΌΠ³/ΠΊΠ³. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠΊΠ°Π·Π°Π½Π½ΡΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠΌΠΎΠ΄ΡΠ»ΡΡΠΎΡΡ ΡΠΌΠ΅Π½ΡΡΠ°ΡΡ Π½Π΅Π³Π°ΡΠΈΠ²Π½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½Π° Π½Π° ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ ΠΈ Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ Π°Π½ΡΠΈΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ, ΡΠΎΡ
ΡΠ°Π½ΡΡΡ ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΊ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ, ΡΡΠΈΠ»ΠΈΠ²Π°Ρ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΡΠ΅Π°ΠΊΡΠΈΡ NΠ-ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊΡΠΎΠ²ΠΈ Π² ΠΎΡΠ²Π΅Ρ Π½Π° ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΈΡΡΡΠΎΠΌ Π³ΡΠΈΠΏΠΏΠ° Π, ΠΈ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠ½ΠΈΠΆΠ°ΡΡ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΎΡ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΠΊΠ°Π·Π°Π½Π½ΡΡ
ΠΈΠΌΠΌΡΠ½ΠΎΠΌΠΎΠ΄ΡΠ»ΡΡΠΎΡΠΎΠ² Π½Π° ΡΠ°ΠΊΡΠΎΡΡ Π°Π½ΡΠΈΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ.A progressive direction of modern pharmacotherapy is search for effective and safe way to reduce immunotoxic effect of doxorubicin without weakening its specific activity. The central role is given to oxidative stress in the mechanisms of cytotoxic and immunotoxic doxorubicin effect, it was logical to study means of prevention immunotoxic effects of this drug among immunomodulators with membranoproteΡtor and antioxidant activity. In animal there were examined the relative influence of immunomodulators amixin, imunofan, polyoxidonium and the state of antiinfection immunity factors in doxorubicin immunosuppressive model that was presented by four-times weekly administration of doxorubicin at a dose of 5.0 mg/kg. It was found that after 4-time introduction doxorubicin develops most profound
immunosuppression, which is accompanied by a profound inhibition of effector activity of NK-cells of blood, almost complete loss of the ability of the body to respond interferon-induced in response to its infectioning with a sublethal dose of influenza A and 100% mortality of virus-infected animals within first 5 days of observations. It is shown that immunomodulators amixin, imunofan and polyoxidonium with different efficiency reduce the negative impact of doxorubicin on cellular and humoral factors of antiviral resistance, retain reactivity to viral infection, increasing interferonogenesis and NK-cell responses of blood in response to infectioning with influenza A and significantly reduce animals mortality from viral infection
ΠΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΈΠ½Π΄ΡΠΊΡΠΎΡΠΎΠΌ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π° Π°ΠΌΠΈΠΊΡΠΈΠ½ΠΎΠΌ
Π¦Π΅Π»Ρ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²: ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΡΠΎΠ»ΠΈ ΡΠΈΡΠΎΠΊΠΈΠ½Π·Π°Π²ΠΈΡΠΈΠΌΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΠΈΠΈ ΠΈ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΈΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΠ½Π΄ΡΠΊΡΠΎΡΠΎΠΌ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π° Π°ΠΌΠΈΠΊΡΠΈΠ½ΠΎΠΌ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π½Π° 228 Π½Π΅Π»ΠΈΠ½Π΅ΠΉΠ½ΡΡ
ΠΌΡΡΠ°Ρ
. ΠΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½ΠΎΠ²ΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΡ Π½Π° ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π»ΠΈ Π²/ΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½Π° Π² Π΄ΠΎΠ·Π΅ 5,0 ΠΌΠ³/ΠΊΠ³ ΠΎΠ΄ΠΈΠ½ ΡΠ°Π· Π² Π½Π΅Π΄Π΅Π»Ρ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 4-Ρ
Π½Π΅Π΄Π΅Π»Ρ. ΠΠΌΠΌΡΠ½ΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠ½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π°ΠΌΠΈΠΊΡΠΈΠ½Π° ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΏΠΎ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ
Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°ΠΊΡΠΈΠ²ΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° ΠΏΠ΅ΡΠΈΡΠΎΠ½Π΅Π°Π»ΡΠ½ΡΠΌΠΈ ΠΌΠ°ΠΊΡΠΎΡΠ°Π³Π°ΠΌΠΈ ΠΈ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΠΌΡΡΠ΅ΠΉ ΠΊ ΠΊΠΎΠΌΠΈΡΠΎΠ³Π΅Π½Π½ΠΎΠΌΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΠ-1Ξ² Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
in vitro. ΠΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π°ΠΌΠΈΠΊΡΠΈΠ½Π° ΡΠΌΠ΅Π½ΡΡΠ°Π΅Ρ Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΠ΅ΠΊΡΠ΅ΡΠΎΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΠ΅ΡΠΈΡΠΎΠ½Π΅Π°Π»ΡΠ½ΡΡ
ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ², Π²ΠΎΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°Π΅Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΉ ΡΠ΅Π·Π΅ΡΠ² ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ ΠΠΠ€ ΠΏΡΠΈ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ² ΡΡΠ°ΡΠΈΠ»ΠΎΠΊΠΎΠΊΠΊΠ°ΠΌΠΈ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
in vitro ΠΈ ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΠΊ ΠΌΠΎΠ΄ΡΠ»ΠΈΡΡΡΡΠ΅ΠΌΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΠ-1Ξ² Π² Π ΠΠ’Π. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅: Π΄ΠΎΠΊΠ°Π·Π°Π½ΠΎ ΠΈΠΌΠΌΡΠ½ΠΎΠΌΠΎΠ΄ΡΠ»ΠΈΡΡΡΡΠ΅Π΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π°ΠΌΠΈΠΊΡΠΈΠ½Π° ΠΏΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΎΠΊΡΠΎΡΡΠ±ΠΈΡΠΈΠ½-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠΈ.To examine the role cytokine-dependent processes in the formation mechanisms of doxorubicin-induced immunosuppression and the opportunity to establish their pharmacological correction inducer of endogenous interferon Amixin. Materials and methods. The study was performed on 228 mice nonlinear. Doxorubicin immunosuppression simulated animal intramuscular injection of doxorubicin at a dose of 5.0 mg / kg once per week for 4 weeks. Immunotropic effect amixin evaluated by changes in production LAF-factor peritoneal macrophages and sensitivity of peripheral blood lymphocytes of mice exposed to comitogenic IL-1Ξ² in conditions in vitro. Results. The use of prophylactic amixin reduces doxorubicin-induced disorders of the secretory activity of peritoneal macrophages, restores functional reserve LAF-production with additional stimulation of macrophages in staphylococci in vitro and increases the sensitivity of peripheral blood lymphocytes to the modulating effects of IL-1Ξ² in blasttransformation test. Amixin proven immunomodulatory effects in experimental doxorubicin-induced immunosuppression