Towards Realization of Intelligent Medical Treatment at Nanoscale by Artificial Microscopic Swarm Control Systems

Background: In this paper, the novel concept of artificial microscopic swarm control systems is proposed as a promising approach towards realization of intelligent medical treatment at nanoscale. In this new paradigm, treatment is done autonomously at nanoscale within the patient’s body by the proposed swarm control systems.Methods: From control engineering perspective, medical treatment can be considered as a control problem, in which the ultimate goal is to find the best feasible way to change the state of diseased tissue from unhealthy to healthy in presence of uncertainty. Although a living tissue is a huge swarm of microscopic cells, nearly all of the common treatment methods are based on macroscopic centralized control paradigm. Inspired by natural microscopic swarm control systems such as nervous, endocrine and immune systems that work based on swarm control paradigm, medical treatment needs a paradigm shift from macroscopic centralized control to microscopic swarm control. An artificial microscopic swarm control system consists of a huge number of very simple autonomous microscopic agents that exploit swarm intelligence to realize sense, control (computing) and actuation at nanoscale in local, distributed and decentralized manner. This control system can be designed based on mathematical analysis and computer simulation.Results: The proposed approach is used for treatment of atherosclerosis and cancer based on mathematical analysis and in-silico study.Conclusion: The notion of artificial microscopic swarm control systems opens new doors towards realization of autonomous and intelligent medical treatment at nanoscale within the patient’s body

A Novel Adaptive Neural Sliding Mode Control for Systems with Unknown Dynamics

In this paper, an adaptive neural sliding mode controller (ANSMC) is proposed as an asymptotically stable robust controller for a class of Control Affine Nonlinear Systems (CANSs) with unknown dynamics. In the proposed method a Control Affine Radial Basis function Network (CARBFN) is developed for online identification of CANSs. A recursive algorithm based on Extended Kalman Filter (EKF) is used for training of CARBFN to develop an adaptive model for CANSs with unknown and uncertain system dynamics to reduce the uncertainties to low values. Since the CARBFN model learns the system time-varying dynamics online, the ANSMC will compute an efficient control input adaptively. Due to high degree of robustness, the proposed controller can be widely used in real world applications. To demonstrate this efficiency, a robust control system is successfully designed for a chaotic Duffing forced oscillator system in the presence of unknown dynamics as well as the unknown oscillation disturbance which is not available for measurement

Modeling a Data Mining Decision Tree and Propose a New Model for the Diagnosis of Skin Cancer by Immunohistochemical Staining Methods

Introduction: New diagnostic methods like immunohistochemistry staining in skin cancer can help the physicians to have more accurate diagnosis. The purpose of this study was to compare a method based on decision tree for differential diagnosis of two kind of skin cancer (Basal cell cancer and Squamous cell cancer) based on the results of staining methods. Method: Sixty skin cancer patients’ data from Malaysia were assessed by two methods of decision tree, CART and CHAID, in data mining and using Clementine 12 and SPSS 19. The results of three staining methods including B-cell lymphoma-2 antibody (BCL2), Galectin-3 (Cytoplasm), and Galectin-3 (Nucleus) were analyzed. The best predictive model for decision tree induction was compared with another researcher-made model based on critical values resulted from Receiver Operating Characteristic (ROC) curve analysis. Results: In final synthetic model, the sensitivity and specificity for Basal Cell Carcinoma (BCC) were 82.1% and 100%, and for Squamous Cell Carcinoma (SCC) were 100% and 82.8%, respectively. The overall accuracy of the model was 90.38% and the positive predictive values (PPV) for SCC and BCC were 82.1% and 100%, and the positive likelihood ratios (PLR) were 5.8 and 5.5 respectively. Conclusion: The decision tree model based on two methods of immunohistochemistry staining in skin cancer, can help in the diagnosis of these malignant disease and provide further studie

Feature selection using genetic algorithm for breast cancer diagnosis: experiment on three different datasets

Objective(s): This study addresses feature selection for breast cancer diagnosis. The present process uses a wrapper approach using GA-based on feature selection and PS-classifier. The results of experiment show that the proposed model is comparable to the other models on Wisconsin breast cancer datasets. Materials and Methods: To evaluate effectiveness of proposed feature selection method, we employed three different classifiers artificial neural network (ANN) and PS-classifier and genetic algorithm based classifier (GA-classifier) on Wisconsin breast cancer datasets include Wisconsin breast cancer dataset (WBC), Wisconsin diagnosis breast cancer (WDBC), and Wisconsin prognosis breast cancer (WPBC). Results: For WBC dataset, it is observed that feature selection improved the accuracy of all classifiers expect of ANN and the best accuracy with feature selection achieved by PS-classifier. For WDBC and WPBC, results show feature selection improved accuracy of all three classifiers and the best accuracy with feature selection achieved by ANN. Also specificity and sensitivity improved after feature selection. Conclusion: The results show that feature selection can improve accuracy, specificity and sensitivity of classifiers. Result of this study is comparable with the other studies on Wisconsin breast cancer datasets

A General Insight into the Effect of Neuron Structure on Classification

This paper gives a general insight into how the neuron structure in a multilayer perceptron (MLP) can affect the ability of neurons to deal with classification. Most of the common neuron structures are based on monotonic activation functions and linear input mappings. In comparison, the proposed neuron structure utilizes a nonmonotonic activation function and/or a nonlinear input mapping to increase the power of a neuron. An MLP of these high power neurons usually requires a less number of hidden nodes than conventional MLP for solving classification problems. The fewer number of neurons is equivalent to the smaller number of network weights that must be optimally determined by a learning algorithm. The performance of learning algorithm is usually improved by reducing the number of weights, i. e., the dimension of the search space. This usually helps the learning algorithm to escape local optimums, and also, the convergence speed of the algorithm is increased regardless of which algorithm is used for learning. Several 2-dimensional examples are provided manually to visualize how the number of neurons can be reduced by choosing an appropriate neuron structure. Moreover, to show the efficiency of the proposed scheme in solving real-world classification problems, the Iris data classification problem is solved using an MLP whose neurons are equipped by nonmonotonic activation functions, and the result is compared with two well-known monotonic activation functions