Infestation of shore crab gills by a free-living mussel species

Parasitic and commensal species can impact the structure and function of ecological communities and are typically highly specialized to overcome host defences. Here, we report multiple instances of a normally free-living species, the blue mussel Mytilus edulis Linnaeus, 1758, inhabiting the branchial chamber of the shore crab Carcinus maenas (Linnaeus, 1758) collected from widely separated geographical locations. A total of 127 C. maenas were examined from four locations in the English Channel, one location in the Irish Sea and two locations at the entrance of the Baltic Sea. The branchial chambers of three crabs (one from the English Channel and two from Gullmar Fjord, Sweden) were infested with mussels resembling the genus Mytilus. Sequencing at the Me15/16 locus on the polyphenolic adhesive protein gene confirmed the identity as M. edulis. Bivalve infestation always occurred in larger red male individuals. Up to 16 mussels, ranging from 2 to 11 mm in shell length, were found in each individual, either wedged between gill lamellae or attached to the branchial chamber inner wall. This is one of the first reports of a bivalve inhabiting crustacean gills and is an intriguing case of a normally free-living prey species infesting its predato

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Membaca kepribadian untuk konselor: memahami preferensi, motivasi, dan riwayat hidup

Buku ini mengeksplorasi bagaimana konselor dan psikoterapis dapat menggunakan teori dan riset kepribadian kontemporer sebagai perangkat positif untuk memperbaiki hasil terapeutik. Buku ini memberikan penjelasan yang dalam tentan gteori kepribadian modern yang tersedia dalam konseling dan psikoterapi

Moving the debate forward in small steps : a reply to Morrison

Morrison (1996) criticised the authors' 1995 evaluation on three main grounds: that it was too narrow, that it was circular, and that the model evaluated was contradictory. It is argued that the narrow focus was deliberate, that the methodology was standard and logical, and that the framework evaluated was coherent. Although the authors agree with Morrison in some respects, e.g. on the value of variety of methodology, there seems to be a basic difference in view on scientific method. The authors see research as (mainly) small steps which are erratic but generally cumulative; Morrison appears to favour grand-scale, multi-purpose research

Effective professionals engaged in reflective practice : a response to Kidd et al.

Training for careers guidance is undergoing rapid and radical change. The Employment Department's January 1995 invitation to bid for pilot programmes for work-based, competency training represents a sharp contrast to the off-the-job academic training which has, for the past 20 years, been located in higher education. An informed debate and well-founded empirical findings would contribute to the constructive management of these changes. However, Kidd et al.'s (1994) research on careers officers' use of theory in guidance interviews is criticised as being seriously flawed. Questions are posed regarding their conceptual framework, several aspects of their methodology, and their apparent lack of awareness of directly relevant theory and research

A multicultural framework in counsellor training : A preliminary evaluation

The multicultural module of a postgraduate Diploma in Counselling was evaluated. The evaluation focused both on former students' experience of the relevance of multiculturalism to their counselling and on which of three perspectives on multiculturalism they most agreed with. The findings confirmed and illustrated the relevance of multiculturalism to practice. The counsellors also expressed a clear preference for an integrationist perspective, with a structuralist approach their second choice