La mortalidad por cáncer en las comarcas de cataluña (1983–1989)

ResumenObjectivosComparar la mortalidad intercomarcal de Cataluña para algunos de los tumores malignos más frecuentes.MetodologíaSe han analizado los datos globales y de cinco localizaciones tumorales específicas relativos a la mortalidad por cáncer de un período de siete años (1983-1989). Se han obtenido las tasas brutas de mortalidad y las específicas para cada localización analizada. La comparación intercomarcal se ha realizado ajustando las tasas por edad mediante el método directo, tomando como referencia la población de Cataluña de 1986. Se han calculado las razones comparativas de mortalidad (RCM) de cada comarca respecto a Cataluña.ResultadosLa mortalidad global por cáncer es más alta en la comarca del Barcelonés para los hombres y en la de Osona para las mujeres. La RCM de los hombres del Barcelonés es la más alta para el cáncer de tráquea, bronquios y pulmón; la de la comarca del Solsonés es la más alta para el cáncer de estómago, y la de la Cerdanya es la más alta para el cáncer de colon y recto. Entre las mujeres, la RCM más alta para el cáncer de tráquea, bronquios y pulmón la presenta la comarca del Montsiá, para el cáncer de mama la del Baix Empordá y para el cáncer de estómago la del Alt Urgell.ConclusionesEl análisis comparativo de la mortalidad por cáncer, por comarcas y por sexos, permite observar importantes diferencias en la manifestación del fenómeno, lo cual puede orientar de manera más específica las políticas de control del cáncer y de investigación a desarrollar en cada territorio.SummaryObjectivesTo compare mortality among counties (comarques) in Catalonia, Spain for the most frequent malignant tumors.MethodsOverall mortality data and for five specific tumor sites were analyzed for a five-year period (1983-1989). Crude and site-specific mortality rates were computed. The comparison between counties was adjusted for the 1986 population of Catalonia using the direct method. Comparative mortality ratios (CMR) were obtained for each county with respect to Catalonia.ResultsOverall cancer mortality was higher in the Barcelonés for men and in Osona form women. The CMR for men in the Barcelonés was the highest for cancer of the trachea, bronchi and lungs; the CMR in Solsonés was the highest for stomach cancer, while in Cerdanya it was the highest for colorectal cancer. Among women, the highest CMR for cancer of the trachea, bronchi and lungs was in Montsiá, whereas for breast cancer it was Baix Empordá, and Alt Urgell for stomach cancer.ConclusionsComparative analyses of cancer mortality by county in Catalonia and sex underscores differences in its distribution, allowing the orientation of cancer control policies and research to be developed in each geographical area

The effect of renal diet in association with enalapril or benazepril on proteinuria in dogs with proteinuric chronic kidney disease

Treating proteinuria in dogs reduces the progression of chronic kidney disease (CKD); renal diets and angiotensin - converting enzyme (ACE)-inhibitors are cornerstones of treatment. Whether different ACE-inhibitors have distinct kidney protective effects is unknown; it is therefore hypothesized that renal diets and enalapril or benazepril have different beneficial effects in proteinuric CKD dogs. Forty-four dogs with proteinuric CKD (IRIS stages 1-4) were enrolled in the study and were fed renal diet for 30 days. Thereafter, they were randomly assigned to one of 2 groups. Dogs in group A (n=22) received enalapril (0.5 mg/kg, q12h) and in group B (n=22) benazepril (0.5 mg/kg, q24h); in both groups, dogs were fed the same renal diet. After randomization, dogs were monitored for 120 days. Body weight and body condition score (BCS), serum concentrations of creatinine, blood urea nitrogen (BUN), albumin and total proteins, and urine protein-to-creatinine (UPC) ratio were compared at different time-points. After 30 days of renal diet, creatinine, BUN and UPC ratio decreased significantly (p<0.0001). Compared to randomization, body weight, BCS, albumin, total proteins, creatinine and BUN did not vary during follow-up in the 44 dogs and differences between group A and B were not observed. However, the UPC ratio of group A at day 60, 90 and 150 was significantly lower than in group B and compared to randomization (p<0.05). In group B it did not vary overtime. It is concluded that the renal diet is beneficial to decrease creatinine, BUN and UPC ratio in proteinuric CKD dogs. Enalapril further ameliorates proteinuria if administered along with renal diet

A review of canine babesiosis: The European perspective

Canine babesiosis is a significant tick-borne disease caused by various species of the protozoan genus Babesia. Although it occurs worldwide, data relating to European infections have now been collected for many years. These data have boosted the publication record and increased our working knowledge of these protozoan parasites. Both the large and small forms of Babesia species (B. canis, B. vogeli, B. gibsoni, and B. microti-like isolates also referred to as "B. vulpes" and "Theileria annae") infect dogs in Europe, and their geographical distribution, transmission, clinical signs, treatment, and prognosis vary widely for each species. The goal of this review is to provide veterinary practitioners with practical guidelines for the diagnosis, treatment and prevention of babesiosis in European dogs. Our hope is that these guidelines will answer the most frequently asked questions posed by veterinary practitioners

Nuevos retos moleculares en la conservación animal

The contribution of genetics to wildlife conservation has been stressed often forgetting the existing theoretical and empirical limitations in the use of genetic information to solve ecological and demographic problems. The possibilities of molecular analyses are extensive and the automation of procedures is increasing the efficiency and reducing the cost of molecular technology. With large amounts of molecular data already available, the interest is switching towards the analysis of these data and the interpretation of genetic variability within and across species from a functional perspective. The understanding of the link between genetic variation and fitness or survival is essential in conservation biology and this understanding needs the combination of molecular data with non–molecular (e.g. physiological, behavioural and ecological) data. Progress in this promising field will depend on the trust and collaboration between molecular and field biologists.La contribución de la genética a la conservación de la vida salvaje ha sido enfatizada, olvidándose a menudo que existen limitaciones teóricas y empíricas sobre el uso de la información genética para solucionar problemas ecológicos y demográficos. Los análisis moleculares ofrecen numerosas posibilidades y la automatización de los procesos está incrementando la eficiencia y reduciendo los costes de la tecnología molecular. Con grandes cantidades de datos moleculares ya disponibles, el interés se está desplazando hacia el análisis de dichos datos y la interpretación de la variabilidad genética intraespecífica e interespecífica desde una perspectiva funcional. La comprensión del vínculo entre variabilidad genética y eficacia biológica o supervivencia es esencial en la biología de la conservación, requiriendo esta comprensión la combinación de datos moleculares con datos no moleculares (por ejemplo fisiológicos, de comportamiento y ecológicos). El progreso en este campo tan prometedor debe basarse en la confianza y la colaboración entre biólogos moleculares y de campo

Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe

Canine ehrlichiosis and anaplasmosis are important tick-borne diseases with a worldwide distribution. Information has been continuously collected on these infections in Europe, and publications have increased in recent years. Prevalence rates are high for Ehrlichia and Anaplasma spp. infections in dogs from different European countries. The goal of this article was to provide a practical guideline for veterinary practitioners on the diagnosis, treatment, and prevention of ehrlichiosis and anaplasmosis in dogs from Europe. This guideline is intended to answer the most common questions on these diseases from a practical point of view

Endosymbionts carried by ticks feeding on dogs in Spain

Studies on tick microbial communities historically focused on tick-borne pathogens. However, there is an increasing interest in capturing relationships among non-pathogenic endosymbionts and exploring their relevance for tick biology. The present study included a total of 1600 adult ticks collected from domestic dogs in 4 different biogeographical regions of Spain. Each pool formed by 1 to 10 halves of individuals representing one specific ticks species was examined by PCR for the presence of Coxiellaceae, Rickettsia spp., Rickettsiales, Wolbachia spp., and other bacterial DNA. Of the pools analyzed, 92% tested positive for endosymbiont-derived DNA. Coxiella spp. endosymbionts were the most prevalent microorganisms, being always present in Rhipicephalus sanguineus sensu lato (s.l.) pools. Rickettsia spp. DNA was detected in 60% of Dermacentor reticulatus pools and 40% of R. sanguineus s.l. pools, with a higher diversity of Rickettsia species in R. sanguineus s.l. pools. Our study reveals a negative relationship of Rickettsia massiliae with the presence of tick-borne pathogens in the same pool of ticks. An additional endosymbiont, ‘Candidatus Rickettsiella isopodorum’, was only detected in D. reticulatus pools. Data from this study indicate that dogs in Spain are exposed to several endosymbionts. Due to the importance of tick-borne pathogens, characterizing the role of endosymbionts for tick physiology and prevalence, may lead to novel control strategies

Ultrafast transient liquid assisted growth of high current density superconducting films

The achievement of high growth rates in YBaCuO epitaxial high-temperature superconducting films has become strategic to enable high-throughput manufacturing of long length coated conductors for energy and large magnet applications. We report on a transient liquid assisted growth process capable of achieving ultrafast growth rates (100 nm s −1) and high critical current densities (5 MA cm −2 at 77 K). This is based on the kinetic preference of Ba-Cu-O to form transient liquids prior to crystalline thermodynamic equilibrium phases, and as such is a non-equilibrium approach. The transient liquid-assisted growth process is combined with chemical solution deposition, proposing a scalable method for superconducting tapes manufacturing. Additionally, using colloidal solutions, the growth process is extended towards fabrication of nanocomposite films for enhanced superconducting properties at high magnetic fields. Fast acquisition in situ synchrotron X-ray diffraction and high resolution scanning transmission electron microscopy (STEM) become crucial measurements in disentangling key aspects of the growth process. High throughput manufacturing of long length coated conductors requires fast epitaxial growth of high-temperature superconducting films. Here, Soler et al. report an ultrafast growth rates and high critical current densities of YBaCuO films using a transient liquid-assisted growth method

Confirmation of low genetic diversity and multiple breeding females in a social group of Eurasian badgers from microsatellite and field data

The Eurasian badger ( Meles meles ) is a facultatively social carnivore that shows only rudimentary co-operative behaviour and a poorly defined social hierarchy. Behavioural evidence and limited genetic data have suggested that more than one female may breed in a social group. We combine pregnancy detection by ultrasound and microsatellite locus scores from a well-studied badger population from Wytham Woods, Oxfordshire, UK, to demonstrate that multiple females reproduce within a social group. We found that at least three of seven potential mothers reproduced in a group that contained 11 reproductive age females and nine offspring. Twelve primers showed variability across the species range and only five of these were variable in Wytham. The microsatellites showed a reduced repeat number, a significantly higher number of nonperfect repeats, and moderate heterozygosity levels in Wytham. The high frequency of imperfect repeats and demographic phenomena might be responsible for the reduced levels of variability observed in the badger