Development and trial operation of a site-wide computerized material accounting system at Kurchatov Institute

Since August 1994 Kurchatov Institute in cooperation with several US Department of Energy Laboratories has been developing a site-wide computerized material accounting system for nuclear materials. In 1994 a prototype system was put into trial operation at two Kurchatov facilities. Evaluation of this prototype led to the development of a new computerized material accounting system named KI-MACS, which has been operational since 1996. This system is a site-wide local secure computer network with centralized database capable of dealing with strictly confidential data and performing near-real time accountancy. It utilizes a Microsoft Windows NT operating system with SQL Server and Visual Basic, and has a `star`-like network architecture. KI-MACS is capable of dealing with materials in itemized and bulk form, and can perform statistical evaluations of measurements and material balance. KI-MACS is fully integrated with bar code equipment, electronic scales, gamma-ray spectrometers and an Active Well Coincidence Counter, thus providing almost on-line evaluation and utilization of results of measurements, item identification and accounting. At present KI-MACS is being used in Physical Inventory Taking at the Kurchatov Central Storage Facility, and by the end of 1997 will be installed at twelve Kurchatov nuclear facilities

Performance and scalability of the back-end sub-system in the ATLAS DAQ/EF prototype

The DAQ group of the future ATLAS experiment has developed a prototype system based on the trigger/DAQ architecture described in the ATLAS Technical Proposal to support studies of the full system functionality, architecture as well as available hardware and software technologies. One sub-system of this prototype is the back- end which encompasses the software needed to configure, control and monitor the DAQ, but excludes the processing and transportation of physics data. The back-end consists of a number of components including run control, configuration databases and message reporting system. The software has been developed using standard, external software technologies such as OO databases and CORBA. It has been ported to several C++ compilers and operating systems including Solaris, Linux, WNT and LynxOS. This paper gives an overview of the back-end software, its performance, scalability and current status. (17 refs)

Acute Progression of BCR-FGFR1 Induced Murine B-Lympho/Myeloproliferative Disorder Suggests Involvement of Lineages at the Pro-B Cell Stage

Constitutive activation of FGFR1, through rearrangement with various dimerization domains, leads to atypical myeloproliferative disorders where, although T cell lymphoma are common, the BCR-FGFR1 chimeric kinase results in CML-like leukemia. As with the human disease, mouse bone marrow transduction/transplantation with BCR-FGFR1 leads to CML-like myeloproliferation as well as B-cell leukemia/lymphoma. The murine disease described in this report is virtually identical to the human disease in that both showed bi-lineage involvement of myeloid and B-cells, splenomegaly, leukocytosis and bone marrow hypercellularity. A CD19+ IgM− CD43+ immunophenotype was seen both in primary tumors and two cell lines derived from these tumors. In all primary tumors, subpopulations of these CD19+ IgM− CD43+ were also either B220+ or B220−, suggesting a block in differentiation at the pro-B cell stage. The B220− phenotype was retained in one of the cell lines while the other was B220+. When the two cell lines were transplanted into syngeneic mice, all animals developed the same B-lymphoblastic leukemia within 2-weeks. Thus, the murine model described here closely mimics the human disease with bilineage myeloid and B-cell leukemia/lymphoma which provides a representative model to investigate therapeutic intervention and a better understanding of the etiology of the disease

Pathway Instability Is an Effective New Mutation-Based Type of Cancer Biomarkers

DNA mutations play a crucial role in cancer development and progression. Mutation profiles vary dramatically in different cancer types and between individual tumors. Mutations of several individual genes are known as reliable cancer biomarkers, although the number of such genes is tiny and does not enable differential diagnostics for most of the cancers. We report here a technique enabling dramatically increased efficiency of cancer biomarkers development using DNA mutations data. It includes a quantitative metric termed Pathway instability (PI) based on mutations enrichment of intracellular molecular pathways. This method was tested on 5,956 tumor mutation profiles of 15 cancer types from The Cancer Genome Atlas (TCGA) project. Totally, we screened 2,316,670 mutations in 19,872 genes and 1,748 molecular pathways. Our results demonstrated considerable advantage of pathway-based mutation biomarkers over individual gene mutation profiles, as reflected by more than two orders of magnitude greater numbers by high-quality [ROC area-under-curve (AUC)>0.75] biomarkers. For example, the number of such high-quality mutational biomarkers distinguishing between different cancer types was only six for the individual gene mutations, and already 660 for the pathway-based biomarkers. These results evidence that PI value can be used as a new generation of complex cancer biomarkers significantly outperforming the existing gene mutation biomarkers

Программный комплекс для исследования удаленных междуфазных замыканий на линиях 6–10 (35) кВ с односторонним питанием

The paper considers methodology for creation of software complex while using Fortran software modules and DELPHI object programming system. Software complex is designed for investigation of line operational modes of 6–10 (35) kW with supply on one side and remote inter-phase short circuits. Рассматривается методика создания программного комплекса с использованием фортрановских программных модулей и системы объектного программирования DELРНI. Программный комплекс предназначен для исследования режимов работы линий 6–10 (35) кВ с односторонним питанием при удаленных междуфазных замыканиях

Is there a cloud in the silver lining for imatinib?

Imatinib mesylate (Gleevec® or Glivec®), a small molecule tyrosine kinase inhibitor for the treatment of chronic myeloid leukaemia, has been said to herald the dawn of a new er-a of rationally designed, molecularly targeted oncotherapy. Lurking on the same new horizon, however, is the age-old spectre of drug resistance. This review sets the intoxicating clinical perspective against the more sobering laboratory evidence of such divergent mechanisms of imatinib resistance as gene amplification and stem cell quiescence. Polychemotherapy has already been considered to combat resistance, but a more innovative, as yet unformulated, approach may be advocated

Two different point mutations in ABL gene ATP-binding domain conferring Primary Imatinib resistance in a Chronic Myeloid Leukemia (CML) patient: A case report

Imatinib (Gleevec) is the effective therapy for BCR-ABL positive CML patients. Point mutations have been detected in ATP-binding domain of ABL gene which disturbs the binding of Gleevec to this target leading to resistance. Detection of mutations is helpful in clinical management of imatinib resistance. We established a very sensitive (ASO) PCR to detect mutations in an imatinib-resistant CML patient. Mutations C944T and T1052C were detected which cause complete partial imatinib resistance, respectively. This is the first report of multiple point mutations conferring primary imatinib resistance in same patient at the same time. Understanding the biological reasons of primary imatinib resistance is one of the emerging issues of pharmacogenomics and will be helpful in understanding primary resistance of molecularly-targeted cancer therapies. It will also be of great utilization in clinical management of imatinib resistance. Moreover, this ASO-PCR assay is very effective in detecting mutations related to imatinib resistance

О выборе характеристик срабатывания токовых защит линий в распределительных сетях с односторонним питанием

A brief analysis of operational characteristics of current protection with various current-time curves of distributive network lines with unsoldering is given in the paper. The paper considers possible measures directed on better technical modernization and expansion in the field of application of multi-stage microprocessor current protection in distributive networks with one-side power supply.Выполнен краткий анализ характеристик срабатывания токовых защит с различными времятоковыми характеристиками линий распределительной сети с отпайками. Рассмотрены возможные мероприятия по повышению технического совершенства и расширению области использования многоступенчатых микропроцессорных токовых защит в распределительных сетях с односторонним питанием

ПОВЫШЕНИЕ ТЕХНИЧЕСКОГО СОВЕРШЕНСТВА ТОКОВЫХ И ТОКОВЫХ НАПРАВЛЕННЫХ ЗАЩИТ РАСПРЕДЕЛИТЕЛЬНЫХ СЕТЕЙ

The paper considers principles of execution and methods for investigation of adaptive micro-processor protection of distributive systems with one- and two-side supply. Adaptive current protection  for the systems with one-side supply controls a moment  of non-symmetric  damage  initiation and automatically operate current of measuring elements. Systems with two-side supply presuppose combined usage of methods for determination of damage places and conventional method for execution of protection.Рассматриваются принципы выполнения и методы исследования адаптивных микропроцессорных защит распределительных сетей с одно- и двусторонним питанием. Адаптивная токовая защита для сетей с односторонним питанием контролирует момент  наступления  несимметричного повреждения и автоматически ток срабатывания измерительных органов. В сетях с двусторонним питанием предлагается комбинированное использование методов определения мест повреждений и традиционных методов выполнения защиты

Влияние насыщения трансформаторов тока на работу токовых защит

An analysis of the influence of instrument current transformer errors on operation of current protection of power supply diagram elements has been carried out in the paper. The paper shows the influence of an aperiodic component of transient current and secondary load on current  transformer errors.Peculiar operational features of measuring elements of electromechanical and microprocessor current protection with their joint operation with electromagnetic current transformers have been analyzed in the paper.Произведен анализ влияния погрешностей измерительных трансформаторов тока на работу токовых защит элементов схемы электроснабжения. Показано влияние апериодической составляющей тока переходного режима и вторичной нагрузки на погрешности трансформаторов тока.Произведен анализ особенностей работы измерительных органов электромеханических и микропроцессорных токовых защит при совместной работе с электромагнитными трансформаторами тока