Influence of Coulomb-nuclear interference on the deuteron spin dichroism phenomenon in a carbon target in the energy interval 5–20 MeV

AbstractTheoretical studies of the deuteron beam transmission through the unpolarized target predict the appearance of tensor polarization in transmitted beam due to deuteron spin dichroism. If only nuclear interaction is taken into account when considering this phenomenon, the tensor polarization (spin dichroism) of transmitted beam has a positive sign which agree with conception of different “transverse dimensions” of deuteron in different spin state. However, the first experiments with deuteron with the energy of 5–20 MeV transmitting through unpolarized carbon target show that accumulated polarization in a deuteron beam firstly, has a negative sign and secondly, the increase in the target thickness (and primary deuteron energy) does not bring about the increase in the value of polarization. This can be explained by changing the sign of deuteron spin dichroism in the considered energy interval. In this Letter is shown that the account of the Coulomb interaction by means of the Coulomb-nuclear interference, can qualitatively explain behavior of deuteron spin dichroism in a carbon target in the energy interval from 5 to 20 MeV

Effect of removing the 4-hour access standard in the ED: a retrospective observational study

BACKGROUND: Time-based targets are used to improve patient flow and quality of care within EDs. While previous research often highlighted the benefits of these targets, some studies found negative consequences of their implementation. We study the consequences of removing the 4-hour access standard. METHODS: We conducted a before and after, retrospective, observational study using anonymised, routinely collected, patient-level data from a single English NHS ED between April 2018 and December 2019. The primary outcomes of interest were the proportion of admitted patients, that is, the admission rate, the length of stay in the ED and ambulance handover times. We used interrupted time series models to study and estimate the impact of removing the 4-hour access standard. RESULTS: A total of 169 916 attendances were included in the analysis. The interrupted time series models for the average daily admission rate indicate a drop from an estimated 35% to an estimated 31% (95% CI -4.1 to -3.9). This drop is only statistically significant for Majors (Ambulant) patients (from an estimated 38.3% to an estimated 31.4%) and, particularly, for short-stay admissions (from an estimated 18.1% to an estimated 12.8%). The models also show an increase in the average daily length of stay for admitted patients from an estimated 316 min to an estimated 387 min (95% CI 33.5 to 108.9), and an increase in the average daily length of stay for discharged patients from an estimated 222 min to an estimated 262 min (95% CI 6.9 to 40.4). CONCLUSION: Lifting the 4-hour access standard reporting was associated with a drop in short-stay admissions to the hospital. However, it was also associated with an increase in the average length of stay in the ED. Our study also suggests that the removal of the 4-hour standard does not impact all patients equally. While certain patient groups such as those Majors (Ambulant) patients with less severe issues might have benefited from the removal of the 4-hour access standard by avoiding short-stay hospital admissions, the average length of stay in the ED seemed to have increased across all groups, particularly for older and admitted patients

Analysis of CLDN14 gene in deaf Moroccan patients with non-syndromic hearing loss

Mutations in the CLDN14 gene, encoding the tight junction claudin 14 protein has been reported to date in an autosomal recessive form of isolated hearing loss DFNB29. In order to identify the contribution of CLDN14 to inherited deafness in Moroccan population, we performed a genetic analysis of this gene in 80 Moroccan familial cases. Our results show the presence of 7 mutations: 6 being conservative and one leading to a missense mutation (C11T) which was found at heterozygous and homozygous states, with a general frequency of 6.87%. The pathogenicity of the resulting T4M substitution is under discussion. Finally, our study suggests that CLDN14 gene can be implicated in the development of hearing loss in the Moroccan population

Mediterranean Founder Mutation Database (MFMD): Taking Advantage from Founder Mutations in Genetics Diagnosis, Genetic Diversity and Migration History of the Mediterranean Population

The Mediterranean basin has been the theater of migration crossroads followed by settlement of several societies and cultures in prehistoric and historical times, with important consequences on genetic and genomic determinisms. Here, we present the Mediterranean Founder Mutation Database (MFMD), established to offer web-based access to founder mutation information in the Mediterranean population. Mutation data were collected from the literature and other online resources and systematically reviewed and assembled into this database. The information provided for each founder mutation includes DNA change, amino-acid change, mutation type and mutation effect, as well as mutation frequency and coalescence time when available. Currently, the database contains 383 founder mutations found in 210 genes related to 219 diseases. We believe that MFMD will help scientists and physicians to design more rapid and less expensive genetic diagnostic tests. Moreover, the coalescence time of founder mutations gives an overview about the migration history of the Mediterranean population. MFMD can be publicly accessed from http://mfmd.pasteur.ma

Об одном обобщении квадратурной формулы Эрмита

In this paper we propose a new approach to the construction of quadrature formulas of interpolation rational type on an interval. In the introduction, a brief analysis of the results on the topic of the research is carried out. Most attention is paid to the works of mathematicians of the Belarusian school on approximation theory – Gauss, Lobatto, and Radau quadrature formulas with nodes at the zeros of the rational Chebyshev – Markov fractions. Rational fractions on the segment, generalizing the classical orthogonal Jacobi polynomials with one weight, are defined, and some of their properties are described. One of the main results of this paper consists in constructing quadrature formulas with nodes at zeros of the introduced rational fractions, calculating their coefficients in an explicit form, and estimating the remainder. This result is preceded by some auxiliary statements describing the properties of special rational functions. Classical methods of mathematical analysis, approximation theory, and the theory of functions of a complex variable are used for proof. In the conclusion a numerical analysis of the efficiency of the constructed quadrature formulas is carried out. Meanwhile, the choice of the parameters on which the nodes of the quadrature formulas depend is made in several standard ways. The obtained results can be applied for further research of rational quadrature formulas, as well as in numerical analysis.Целью данной работы является изучение нового подхода к построению квадратурных формул интерполяционно-рационального типа на отрезке. Проведен краткий анализ результатов по теме исследования, где основное внимание уделено работам математиков белорусской школы по теории аппроксимации – квадратурным формулам Гаусса, Лобатто, Радо с узлами в нулях рациональных дробей Чебышева – Маркова. Определяются рациональные дроби на отрезке, обобщающие классические ортогональные многочлены Якоби с одним весом, и описываются некоторые их свойства. Один из основных результатов работы состоит в построении квадратурных формул с узлами в нулях введенных рациональных дробей, вычислении их коэффициентов в явном виде, оценке остатка. Ему предшествуют некоторые вспомогательные утверждения, описывающие свойства специальных рациональных функций. Для доказательства используются классические методы математического анализа, теории приближений и теории функций комплексного переменного. Проводится численный анализ эффективности построенных квадратурных формул. При этом выбор параметров, от которых зависят узлы квадратурных формул, производится несколькими стандартными способами. Полученные результаты могут быть применены для дальнейшего исследования рациональных квадратурных формул, а также в численном анализе

Tensor polarization of deuterons passing through matter

It is shown that the magnitude of tensor polarization of the deuteron beam, which arises owing to the spin dichroism effect, depends appreciably on the angular width of the detector that registers the deuterons transmitted through the target. Even when the angular width of the detector is much smaller than the mean square angle of multiple Coulomb scattering, the beam's tensor polarization depends noticeably on rescattering. When the angular width of the detector is much larger than the mean square angle of multiple Coulomb scattering (as well as than the characteristic angle of elastic nuclear scattering), tensor polarization is determined only by the total reaction cross sections for deuteron-nucleus interaction, and elastic scattering processes make no contribution to tensor polarization.Comment: 18 pages, 3 figures, to be published in IO