LECHERAS Y NOVEDADES [Material gráfico]

ADQUIRIDA POR EL COLECCIONISTA EN TENERIFEFOTO DE GRUPO DE MUJERES LECHERASCopia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 201

Interferon β-1a in relapsing multiple sclerosis: four-year extension of the European IFNβ-1a Dose-C omparison Study

Background: Multiple sclerosis (MS) is a chronic disease requiring long-term monitoring of treatment. Objective: To assess the four-year clinical efficacy of intramuscular (IM) IFNb-1a in patients with relapsing MS from the European IFNb-1a Dose-C omparison Study. Methods: Patients who completed 36 months of treatment (Part 1) of the European IFNb-1a Dose-C omparison Study were given the option to continue double-blind treatment with IFNb-1a 30 mcg or 60 mcg IM once weekly (Part 2). Analyses of 48-month data were performed on sustained disability progression, relapses, and neutralizing antibody (NA b) formation. Results: O f 608/802 subjects who completed 36 months of treatment, 493 subjects continued treatment and 446 completed 48 months of treatment and follow-up. IFNb-1a 30 mcg and 60 mcg IM once weekly were equally effective for up to 48 months. There were no significant differences between doses over 48 months on any of the clinical endpoints, including rate of disability progression, cumulative percentage of patients who progressed (48 and 43, respectively), and annual relapse rates; relapses tended to decrease over 48 months. The incidence of patients who were positive for NAbs at any time during the study was low in both treatment groups. Conclusion: C ompared with 60-mcg IM IFNb-1a once weekly, a dose of 30 mcg IM IFNb-1a once weekly maintains the same clinical efficacy over four years

Trials

BACKGROUND: Postoperative upper gastrointestinal fistula (PUGIF) is a devastating complication, leading to high mortality (reaching up to 80%), increased length of hospital stay, reduced health-related quality of life and increased health costs. Nutritional support is a key component of therapy in such cases, which is related to the high prevalence of malnutrition. In the prophylactic setting, enteral nutrition (EN) is associated with a shorter hospital stay, a lower incidence of severe infectious complications, lower severity of complications and decreased cost compared to total parenteral nutrition (TPN) following major upper gastrointestinal (GI) surgery. There is little evidence available for the curative setting after fistula occurrence. We hypothesize that EN increases the 30-day fistula closure rate in PUGIF, allowing better health-related quality of life without increasing the morbidity or mortality. METHODS/DESIGN: The NUTRILEAK trial is a multicenter, randomized, parallel-group, open-label phase III trial to assess the efficacy of EN (the experimental group) compared with TPN (the control group) in patients with PUGIF. The primary objective of the study is to compare EN versus TPN in the treatment of PUGIF (after esophagogastric resection including bariatric surgery, duodenojejunal resection or pancreatic resection with digestive tract violation) in terms of the 30-day fistula closure rate. Secondary objectives are to evaluate the 6-month postrandomization fistula closure rate, time of first fistula closure (in days), the medical- and surgical treatment-related complication rate at 6 months after randomization, the fistula-related complication rate at 6 months after randomization, the type and severity of early (30 days after randomization) and late fistula-related complications (over 30 days after randomization), 30-day and 6-month postrandomization mortality rate, nutritional status at day 30, day 60, day 90 and day 180 postrandomization, the mean length of hospital stay, the patient's health-related quality of life (by self-assessment questionnaire), oral feeding time and direct costs of treatment. A total of 321 patients will be enrolled. DISCUSSION: The two nutritional supports are already used in daily practice, but most surgeons are reluctant to use the enteral route in case of PUGIF. This study will be the first randomized trial testing the role of EN versus TPN in PUGIF. TRIAL REGISTRATION: ClinicalTrials.gov: NCT03742752. Registered on 14 November 2018.This research program is funded by the French Ministry of Health through Programme Hospitalier de Recherche Clinique 2016

Les sens du "Ren" (ethnographie d'une école de Tai-chi)

Dans une première partie, une approche sociohistorique permet de dénaturaliser les catégories d'arts martiaux et de sports de combat forgées par des acteurs sociaux en lutte pour le contrôle d un champ. Cette première étape permet d'identifier trois idéaux types : les combats codifiés, les combats culturalisés et les pratiques de self-defense. La deuxième partie démontre à partir des données de terrains recueillies que le Tai-chi peut être analysé comme une technique de soi et l école de Tai-chi comme un dispositif visant à l incorporation d un éthos confucéen par les élèves. La troisième partie montre la subjectivation des élèves repose sur l incorporation d une culture kinesthésique. Cependant, les élèves transforment le dispositif d éthopoïèse confucéen du maître en un dispositif d exopoïèse. Le Ren , forme idéalisée du lien social confucéen, devient une forme de non-lien social permettant d enraciner l école dans un imaginaire exotique. L école devient ainsi un espace d'altérité radicale permettant un déplacement récréatif, une sublimation du quotidien. Cet espace devient ainsi un lieu privilégié de réinvention de soi.In the first part of thesis, a socio-historical analysis allows an unnaturalision of the concept of martial arts and combat sport created by social actors in their struggle for controlling a field. This first step enables us to identify three ideal types : the codified combat, culturalised combat and self-defence practice. The second part shows from the field data that Tai-chi could be analysed as a technology of the self and the Tai-chi school as an apparatus aiming at the embodiment of a Confucian ethos by the students. The third part points out that the student subjectivation lies on the embodiment of a kinaesthetic culture. However, the student transforms the Confucianist éthopoïesis apparatus into an exopoïesis apparatus. The Ren , an idealised form of Confucianist social relations became a form of non-social relations rooting the school in an exotic imaginary. The school thus became a space of radical alterity enabling a recreative shift, a sublimation of everyday life. Thus, the school became a favoured place of self-reinvention.MONTPELLIER-BU Lettres (341722103) / SudocSudocFranceF

Real-life Use of Bexarotene for T-cell Cutaneous Lymphoma Management: Efficacy and Tolerance with Low Doses

International audienceAbstract is missing (Short communication

Benzamide derivative radiotracers targeting melanin for melanoma imaging and therapy: Preclinical/clinical development and combination with other treatments

International audienc

A case of severe pityriasis rubra pilaris with a dramatic response to apremilast.

International audienc