Unbinned test of time-dependent signals in real-time neutrino oscillation experiments

Real-time neutrino oscillation experiments such as Super-Kamiokande (SK), the Sudbury Neutrino Observatory (SNO), the Kamioka Liquid scintillator Anti-Neutrino Detector (KamLAND), and Borexino, can detect time variations of the neutrino signal, provided that the statistics is sufficiently high. We quantify this statement by means of a simple unbinned test, whose sensitivity depends on the variance of the signal in the time domain, as well as on the total number of signal and background events. The test allows a unified discussion of the statistical uncertainties affecting current or future measurements of eccentricity-induced variations and of day-night asymmetries (in SK, SNO, and Borexino), as well as of reactor power variations (in KamLAND).Comment: 17 pages, including 3 figure

AN EXAMINATION OF THE IMPACT OF HEALTH LITERACY ASSESSMENT ON INCARCERATED INDIVIDUALS WITH A DIAGNOSIS OF TYPE 2 DIABETES

Low health literacy levels limit healthcare outcomes in a variety of diagnoses. Having a low health literacy level can significantly impact an individual’s ability to manage their condition. Among these individuals are incarcerated individuals, who are especially vulnerable to low health literacy levels. Due to regulations of the correctional facility, along with the vulnerability of the population, it is often difficult to get approval for studies and to make changes within this setting[TMD1] . The stigma of incarceration, along with the difficulty in navigating the correctional setting regulations, often create barriers to making changes that could improve the health of incarcerated individuals. Few studies have been completed on health literacy levels of incarcerated individuals. The Newest Vital Sign is a reliable and valid tool that is being used in a multitude of settings and languages to assess health literacy levels. The purpose of this project was to determine health literacy levels of incarcerated individuals with type 2 diabetes in a Midwestern facility along with the impact of educational materials provided over a one-month period of time. Using the appropriate tools to determine health literacy along with proper literacy-leveled education is paramount to positive health outcomes[TMD2] . This project aimed to focus on type 2 diabetes and health literacy factors associated with disease management

Why do the maximum intensities in modeled tropical cyclones vary under the same environmental conditions?

In this study w e explored why the different initial tropical cyclone structures can result in different steady‐state maximum intensities in model simulations with the same environmental conditions. We discovered a linear relationsh ip between the radius of maximum wind (rm) and the absolute angular momentum that passes through rm (Mm) in the model simulated steady‐state tropical cyclones that rm = aMm+b. This nonnegligible intercept b is found to be the key to making a steady‐state storm with a larger Mm more intense. The sensitivity experiments show that this nonzero b results mainly from horizontal turbulent mixing and decreases with decreased horizontal mixing. Using this linear relationship from the simulations, it is also found that the degree of supergradient wind is a function of Mm as well as the turbulent mixing length such that both a larger Mm and/or a reduced turbulent mixing length result in larger supergradient winds

Vertical-velocity skewness in the marine stratus-topped boundary layer

Vertical-velocity skewness, S(sub w), in a turbulent flow is important in several regards. S(sub w) is indicative of the structure of the motion when it is positive, updrafts are narrower and stronger than surrounding downdrafts, and vice versa. Aircraft measurements often suggest cool, narrow downdrafts at some distance below the stratus cloud top, indicating a negative S(sub w) (Nicholls and Leighton, 1986). This seems natural as the turbulence within the stratus-topped boundary layer (CTBL) is driven mainly by the radiative cooling at the cloud top (although sometimes surface heating can also play a major role). One expects intuitively (e.g., Nicolls, 1984) that, in the situations where cloud-top cooling and surface heating coexist, the turbulence statistics in the upper part of the CTBL are influenced more by the cloud-top cooling, while those in the lower part, more by the surface heating. Thus one expects negative S(sub w) in the upper part, and positive in the lower part, in this case. In contradistinction, large-eddy simulations (LES) of the CTBL show just the opposite: the S(sub w) is positive in the upper part and negative in the lower part of the layer. To understand the nature of vertical-velocity skewness, the simplest type of buoyancy-driven turbulence (turbulent Rayleigh-Benard convection) is studied through direct numerical simulation

Identifying, Targeting, and Exploiting a Common Misfolded, Toxic Conformation of SOD1 in ALS: A Dissertation

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a loss of voluntary movement over time, leading to paralysis and death. While 10% of ALS cases are inherited or familial (FALS), the majority of cases (90%) are sporadic (SALS) with unknown etiology. Approximately 20% of FALS cases are genetically linked to a mutation in the anti-oxidizing enzyme, superoxide dismutase (SOD1). SALS and FALS are clinically indistinguishable, suggesting a common pathogenic mechanism exists for both types. Since such a large number of genetic mutations in SOD1 result in FALS (\u3e170), it is reasonable to suspect that non-genetic modifications to SOD1 induce structural perturbations that result in ALS pathology as well. In fact, misfolded SOD1 lacking any genetic mutation was identified in end stage spinal cord tissues of SALS patients using misfolded SOD1-specific antibodies. In addition, this misfolded WT SOD1 found in SALS tissue inhibits axonal transport in vitro, supporting the notion that misfolded WT SOD1 exhibits toxic properties like that of FALS-linked SOD1. Indeed, aberrant post-translational modifications, such as oxidation, cause WT SOD1 to mimic the toxic properties of FALS-linked mutant SOD1. Based on these data, I hypothesize that modified, misfolded forms of WT SOD1 contribute to SALS disease progression in a manner similar to FALS linked mutant SOD1 in FALS. The work presented in this dissertation supports this hypothesis. Specifically, one common misfolded form of SOD1 is defined and exposure of this toxic region is shown to enhance SOD1 toxicity. Preventing exposure, or perhaps stabilization, of this “toxic” region is a potential therapeutic target for a subset of both familial and sporadic ALS patients. Further, the possibility of exploiting this misfolded SOD1 species as a biomarker is explored. For example, an over-oxidized SOD1 species was identified in peripheral blood mononuclear cells (PBMCs) from SALS patients that is reduced in controls. Moreover, 2-dimensional gel electrophoresis revealed a more negatively charged species of SOD1 in PBMCs of healthy controls greatly reduced in SALS patients. This species is hypothesized to be involved in the degradation of SOD1, further implicating both misfolded SOD1 and altered protein homeostasis in ALS pathogenesis

Probing particle and nuclear physics models of neutrinoless double beta decay with different nuclei

Half-life estimates for neutrinoless double beta decay depend on particle physics models for lepton flavor violation, as well as on nuclear physics models for the structure and transitions of candidate nuclei. Different models considered in the literature can be contrasted - via prospective data - with a "standard" scenario characterized by light Majorana neutrino exchange and by the quasiparticle random phase approximation, for which the theoretical covariance matrix has been recently estimated. We show that, assuming future half-life data in four promising nuclei (Ge-76, Se-82, Te-130, and Xe-136), the standard scenario can be distinguished from a few nonstandard physics models, while being compatible with alternative state-of-the-art nuclear calculations (at 95% C.L.). Future signals in different nuclei may thus help to discriminate at least some decay mechanisms, without being spoiled by current nuclear uncertainties. Prospects for possible improvements are also discussed.Comment: Minor corrections in the text, references added. Matches published version in Phys. Rev. D 80, 015024 (2009

Neutrino mass and mixing parameters: A short review

We present a brief review of the current status of neutrino mass and mixing parameters, based on a comprehensive phenomenological analysis of neutrino oscillation and non-oscillation searches, within the standard three-neutrino mixing framework.Comment: 11 pages, including 7 figures. Presented at the 40th Rencontres de Moriond on Electroweak Interactions and Unified Theories, La Thuile, Aosta Valley, Italy, 5-12 Mar 200

Mantle geoneutrinos in KamLAND and Borexino

The KamLAND and Borexino experiments have observed, each at ~4 sigma level, signals of electron antineutrinos produced in the decay chains of thorium and uranium in the Earth's crust and mantle (Th and U geoneutrinos). Various pieces of geochemical and geophysical information allow an estimation of the crustal geoneutrino flux components with relatively small uncertainties. The mantle component may then be inferred by subtracting the estimated crustal flux from the measured total flux. To this purpose, we analyze in detail the experimental Th and U geoneutrino event rates in KamLAND and Borexino, including neutrino oscillation effects. We estimate the crustal flux at the two detector sites, using state-of-the-art information about the Th and U distribution on global and local scales. We find that crust-subtracted signals show hints of a residual mantle component, emerging at ~2.4 sigma level by combining the KamLAND and Borexino data. The inferred mantle flux slightly favors scenarios with relatively high Th and U abundances, within +-1 sigma uncertainties comparable to the spread of predictions from recent mantle models.Comment: Slight changes and improvements in the text & figures. Results unchanged. To appear in Phys. Rev.