Faithful reproduction of network experiments

The proliferation of cloud computing has compelled the research community to rethink fundamental aspects of network systems and architectures. However, the tools commonly used to evaluate new ideas have not kept abreast of the latest developments. Common simulation and emulation frameworks fail to provide scalability, fidelity, reproducibility and execute unmodified code, all at the same time. We present SELENA, a Xen-based network emulation framework that offers fully reproducible experiments via its automation interface and supports the use of unmodified guest operating systems. This allows out-of-the-box compatibility with common applications and OS components, such as network stacks and filesystems. In order to faithfully emulate faster and larger networks, SELENA adopts the technique of time-dilation and transparently slows down the passage of time for guest operating systems. This technique effectively virtualizes the availability of host’s hardware resources and allows the replication of scenarios with increased I/O and computational demands. Users can directly control the tradeoff between fidelity and running-times via intuitive tuning knobs. We evaluate the ability of SELENA to faithfully replicate the behaviour of real systems and compare it against existing popular experimentation platforms. Our results suggest that SELENA can accurately model networks with aggregate link speeds of 44 Gbps or more, while improving by four times the execution time in comparison to ns3 and exhibits near-linear scaling properties.This is the author accepted manuscript. The final version is available from ACM via http://dx.doi.org/10.1145/2658260.265827

Cystoid macular edema

We review the epidemiology, pathophysiology, and etiology of cystoid macular edema (CME). Inflammatory, diabetic, post-cataract, and macular edema due to age-related macular degeneration is described. The role of chronic inflammation and hypoxia and direct macular traction is evaluated in each case according to different views from the literature. The different diagnostic methods for evaluating the edema are described. Special attention is given to fluoroangiography and the most modern methods of macula examination, such as ocular coherence tomography and multifocal electroretinography. Finally, we discuss the treatment of cystoid macular edema in relation to its etiology. In this chapter we briefly refer to the therapeutic value of laser treatment especially in diabetic maculopathy or vitrectomy in some selected cases. Our paper is focused mainly on recent therapeutic treatment with intravitreal injection of triamcinolone acetonide and anti-VEGF factors like bevacizumab (Avastin), ranibizumab (Lucentis), pegaptamid (Macugen), and others. The goal of this paper is to review the current status of this treatment for macular edema due to diabetic maculopathy, central retinal vein occlusion and post-cataract surgery. For this reason the results of recent multicenter clinical trials are quoted, as also our experience on the use of intravitreal injections of anti-VEGF factors and we discuss its value in clinical practice

Enabling Performance Evaluation beyond 10 Gbps

Despite network monitoring and testing being critical for computer networks, current solutions are both extremely expensive and inflexible. This demo presents OSNT (www.osnt.org), a community-driven, high-performance, open-source traffic generator and capture system built on top of the NetFPGA-10G board which enables flexible network testing. The platform supports full line-rate traffic generation regardless of packet size across the four card ports, packet capture filtering and packet thinning in hardware and sub-msec time precision in traffic generation and capture, corrected using an external GPS device. Furthermore, it provides a software APIs to test the dataplane performance of multi-10G switches, providing a starting point for a number of different test cases. OSNT flexibility is further demonstrated through the OFLOPS-turbo platform: an integration of OSNT with the OFLOPS OpenFlow switch performance evaluation platform, enabling control and data plane evaluation of 10G switches. This demo showcases the applicability of the OSNT platform to evaluate the performance of legacy and OpenFlow-enabled networking devices, and demonstrates it using commercial switches

Supporting novel home network management interfaces with Openflow and NOX

The Homework project has examined redesign of existing home network infrastructures to better support the needs and requirements of actual home users. Integrating results from several ethnographic studies, we have designed and built a home networking platform providing detailed per-flow measurement and management capabilities supporting several novel management interfaces. This demo specifically shows these new visualization and control interfaces, and describes the broader benefits of taking an integrated view of the networking infrastructure, realised through our router's augmented measurement and control APIs. Aspects of this work have been published: the Homework Database in Internet Management (IM) 2011 and implications of the ethnographic results are to appear at the SIGCOMM W-MUST workshop 2011. Separate, more detailed expositions of the interface elements and system performance and implications are currently under submission at other venues. A partial code release is already available and we anticipate fuller public beta release by Q4 2011

Reconfigurable network systems and software-defined networking

Modern high-speed networks have evolved from relatively static networks to highly adaptive networks facilitating dynamic reconfiguration. This evolution has influenced all levels of network design and management, introducing increased programmability and configuration flexibility. This influence has extended from the lowest level of physical hardware interfaces to the highest level of network management by software. A key representative of this evolution is the emergence of softwaredefined networking (SDN). In this paper, we review the current state of the art in reconfigurable network systems, covering hardware reconfiguration, SDN, and the interplay between them. We take a top-down approach, starting with a tutorial on software-defined networks. We then continue to discuss programming languages as the linking element between different levels of software and hardware in the network. We review electronic switching systems, highlighting programmability and reconfiguration aspects, and describe the trends in reconfigurable network elements. Finally, we describe the state of the art in the integration of photonic transceiver and switching elements with electronic technologies, and consider the implications for SDN and reconfigurable network systems.This work was jointly supported by the UKs Engineering and Physical Sciences Research Council (EPSRC) Internet Project EP/H040536/1, an EPSRC Research Fellowship grant to Philip Watts (EP/I004157/2), and DARPA and AFRL under contract FA8750-11-C-0249.This is the final version of the article. It first appeared from IEEE via http://dx.doi.org/10.1109/JPROC.2015.243573

A comparison of manifest refractions, cycloplegic refractions and retinoscopy on the RMA-3000 autorefractometer in children aged 3 to 15 years

T Rotsos,1 D Grigoriou,2 A Kokkolaki,2 N Manios21Moorfields eye hospital, London, UK; 2Department of Ophthalmology, General Children’s Hospital, Penteli, Athens, GreecePurpose: The study was conducted to compare the accuracy of readings of the RMA-3000 autorefractometer (Topcon, Tokyo, Japan) with traditional retinoscopy as a means of determining the approximate subjective refraction in children after cycloplegia.Methods: 142 children aged 3 to 15 years were included. All children had their refractive status measured with the RMA-3000 autorefractometer (noncycloplegic autorefraction [AR]). Subsequently all children underwent cycloplegia and the refractive status was estimated again with the autorefractometer (cycloplegic autorefraction [ARC]) and traditional retinoscopy (RC) by examiners who were unaware of the results from the other techniques.Results: From 69 right eyes with negative sphere we observed that the sphere power was significantly higher (more than 0.5 diopters) in AR than in ARC (P = 0.0001) and RC (P = 0.0001). From the 73 normal and hyperopic right eyes we observed that the sphere power was significantly lower (more than 0.5 diopters) in AR than in ARC (P = 0.0001) and RC (P = 0.0001). Conclusions: The use of the autorefractometer in children (in whom accommodation is more active than older patients) without cycloplegia may underestimate the actual hyperopia and overestimate the actual myopia. Manual retinoscopy is still the most accurate technique to estimate refractive status in children.Keywords: refractometer, cycloplegia, retinoscopy, myopia, hyperopia, astigmatis

Initial clinical experience of ranibizumab therapy for neovascular age-related macular degeneration

PURPOSE: To describe the visual acuity and safety outcomes for the first 50 patients with neovascular age-related macular degeneration (nAMD) treated with ranibizumab at Moorfields Eye Hospital. METHODS: A retrospective analysis of case notes from the first 50 consecutive patients with Primary Care Trust funding for ranibizumab therapy for nAMD. Visual acuity outcomes and adverse events were noted, as were service delivery-related indicators. RESULTS: The mean (±standard deviation) age of the 50 patients was 81 ± 17 years. The mean follow-up of patients was 13.6 ± 2 (range 7.7-18) months. The mean change in visual acuity ± standard error was +4.6 ± 2.2 letters at the end of follow-up, with 26% gaining 15 letters or more. The mean (median) number of injections was 4.7 (4.5) per 12-month period. The mean (median) delay in Primary Care Trust funding approval was 35 days (32 days) prior to the final appraisal document from the National Institute of Health and Clinical Excellence. CONCLUSIONS: The real-world outcomes of ranibizumab therapy in this initial cohort of patients with nAMD are comparable with those reported in the pivotal, randomized, controlled trials using fewer injections and a prn strategy of retreatment to achieve the gain in visual acuity

The software defined transport network:fundamentals, findings and futures

The Software Defined Network (SDN) is an established network paradigm, architecture and principles, that attracted significant research effort in recent years. An SDN-enabled infrastructure decouples network control from forwarding and enables direct programming. Recently, there is an increasing effort to introduce SDN support in the transport layers of the network operators WAN infrastructure, like Layer 0 (WDM & DWDM) and Layer 1 (SONET/SDH & OTN) technologies. We refer to this infrastructure as the “Software Defined Transport Network”, and benefits include network management devolvement, timely connectivity provision, improved scalability, and open and flexible programmability using well-defined API. This paper outlines the main elements of Software Defined Transport Networks and highlights relevant Application-Based Network Operations (ABNO) enabling technologies. We demonstrate how this technology will benefit network operators, and provide an overview of research results and deployment examples. Finally, we identify some of the technology gaps and future research opportunities

λBGP:Rethinking BGP programmability

BGP has long been the de-facto control plane protocol for inter-network connectivity. Although initially designed to provide best-effort routing between ASes, the evolution of Internet services has created a demand for more complex control functionalities using the protocol. At the heart of this challenge lies the static nature of configuration mechanisms and the limited programmability of existing BGP speakers. Meanwhile, the SDN paradigm has demonstrated that open and generic network control APIs can greatly improve network functionality and seamlessly enable greater flexibility in network management. In this paper, we argue that BGP speaking systems can and should provide an open and rich control and configuration mechanism, in order to address modern era network control requirements. Towards this goal, we present λbgp, a modular and extensible BGP framework written in Haskell. The framework offers an extensible integration model for reactive BGP control that remains backward compatible with existing BGP standards and allows network managers to define route processing policies using a high-level language and to dynamically inject information sources into the path selection logic. Using a high-performance BGP traffic generator, we demonstrate that λbgp offers performance comparable to production BGP speakers, while dynamic AS route processing policies can be written in just a few lines of code