24 research outputs found
Early Measles Vaccination During an Outbreak in the Netherlands: Short-Term and Long-Term Decreases in Antibody Respo
Background. The majority of infants will not be protected by maternal antibodies until their first measles vaccination, between
12 and 15 months of age. This provides incentive to reduce the age at measles vaccination, but immunological consequences are insufficiently understood, and long-term effects are largely unknown.
Methods. A total of 79 infants who received early measles vaccination between 6 and 12 months age and a second dose at
14 months of age were compared to 44 children in a control group who received 1 dose at 14 months of age. Measles virus–specific
neutralizing antibody concentrations and avidity were determined up to 4 years of age.
Results. Infants who first received measles vaccination before 12 months of age had a long-term decrease in the concentration
and avidity of measles virus–specific neutralizing antibodies, compared with infants in the control group. For 11.1% of children with
a first dose before 9 months of age, antibody levels at 4 years of age had dropped below the cutoff for clinical protection.
Conclusions. Early measles vaccination provides immediate protection in the majority of infants but yields a long-term decrease
in neutralizing antibody responses, compared to vaccination at a later age. Additional vaccination at 14 months of age does not improve this. Over the long term, this may result in an increasing number of children susceptible to measles
COVID-19 vaccination: the VOICE for patients with cancer
Pathogenesis and treatment of chronic pulmonary disease
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause lifethreatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation
of host and pathogen is known to play a role in invasive pneumococcal disease, though to
what extent is unknown. In a genome-wide association study of human and pathogen we
show that human variation explains almost half of variation in susceptibility to pneumococcal
meningitis and one-third of variation in severity, identifying variants in CCDC33 associated
with susceptibility. Pneumococcal genetic variation explains a large amount of invasive
potential (70%), but has no effect on severity. Serotype alone is insufficient to explain
invasiveness, suggesting other pneumococcal factors are involved in progression to invasive
disease. We identify pneumococcal genes involved
Stress hormones, genotype, and brain organization : imlications for aggression
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Neonatally maternally deprived rats have as adults elevated basal pituitary-adrenal activity and enhanced susceptibility to apomorphine.
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Brain-Corticosteroid Hormone Dialogue: Slow and Persistent
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Rats bred for enhanced apomorphine susceptibility have elevated tyrosine hydroxylase mRNA and dopamine D2-receptor binding sites in nigrostriatal and tuberoinfundibular dopamine systems
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Divergent prolactin and pituitary-adrenal activity in rats selectively bred for different dopamine responsiveness
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23725___.PDF (publisher's version ) (Open Access