4,022 research outputs found
Netbank: The Conservative Internet Entrepreneurs
NetBank is a successful Internet startup. In late 2001 it was the only Internet Bank that really succeeded in the U.S. By the end of 2001, NetBank operated nation wide with nearly a quarter of a million customers. The number of accounts grew at 275 percent per annum compounded since incorporation. This case describes the development of NetBank and addresses the issues it faced in handling rapid growth as it implemented Internet banking
The range of the tangential Cauchy-Riemann system on a CR embedded manifold
We prove that every compact, pseudoconvex, orientable, CR manifold of \C^n,
bounds a complex manifold in the sense. In particular, the
tangential Cauchy-Riemann system has closed range
B cells in the aging immune system: time to consider B-1 cells
The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B-1 cell subset is an essential arm of the innate immune system, which in general has been understudied in terms of immune senescence. Here, we review what is currently known about B cells during aging and go on to describe why B-1 cell biology is an important component of the aging immune system in the context of diseases that most affect the aged population
Splenic B-1a Cells Expressing CD138 Spontaneously Secrete Large Amounts of Immunoglobulin in Naive Mice
B-1a cells constitutively secrete natural antibody that provides immediate protection against microbial pathogens and functions homeostatically to speed removal of apoptotic cell debris. Although B-1a cells are especially prominent in the peritoneal and pleural cavities, some B-1a cells reside in the spleen. A small subset of splenic B-1a cells in naive, unimmunized mice express CD138, a recognized plasma cell antigen, whereas the bulk of splenic B-1a cells are CD138 negative. Splenic B-1a cells in toto have been shown to generate much more antibody per cell than peritoneal B-1a cells; however, specific functional information regarding CD138(+) splenic B-1a cells has been lacking. Here, we find a higher proportion of CD138(+) splenic B-1a cells spontaneously secrete more IgM as compared to CD138(-) B-1a cells. Moreover, IgM secreted by CD138(+) splenic B-1a cells is skewed with respect to N-region addition, and some aspects of VH and JH utilization, as compared to CD138(-) splenic B-1a cells and peritoneal B-1a cells. The small population of CD138(+) splenic B-1a cells is likely responsible for a substantial portion of natural IgM and differs from IgM produced by other B-1a cell subsets
Renormalization Group Treatment of Nonrenormalizable Interactions
The structure of the UV divergencies in higher dimensional nonrenormalizable
theories is analysed. Based on renormalization operation and renormalization
group theory it is shown that even in this case the leading divergencies
(asymptotics) are governed by the one-loop diagrams the number of which,
however, is infinite. Explicit expression for the one-loop counter term in an
arbitrary D-dimensional quantum field theory without derivatives is suggested.
This allows one to sum up the leading asymptotics which are independent of the
arbitrariness in subtraction of higher order operators. Diagrammatic
calculations in a number of scalar models in higher loops are performed to be
in agreement with the above statements. These results do not support the idea
of the na\"ive power-law running of couplings in nonrenormalizable theories and
fail (with one exception) to reveal any simple closed formula for the leading
terms.Comment: LaTex, 11 page
Matched Asymptotic Expansion for Caged Black Holes - Regularization of the Post-Newtonian Order
The "dialogue of multipoles" matched asymptotic expansion for small black
holes in the presence of compact dimensions is extended to the Post-Newtonian
order for arbitrary dimensions. Divergences are identified and are regularized
through the matching constants, a method valid to all orders and known as
Hadamard's partie finie. It is closely related to "subtraction of
self-interaction" and shows similarities with the regularization of quantum
field theories. The black hole's mass and tension (and the "black hole
Archimedes effect") are obtained explicitly at this order, and a Newtonian
derivation for the leading term in the tension is demonstrated. Implications
for the phase diagram are analyzed, finding agreement with numerical results
and extrapolation shows hints for Sorkin's critical dimension - a dimension
where the transition turns second order.Comment: 28 pages, 5 figures. v2:published versio
Non-Relativistic Gravitation: From Newton to Einstein and Back
We present an improvement to the Classical Effective Theory approach to the
non-relativistic or Post-Newtonian approximation of General Relativity. The
"potential metric field" is decomposed through a temporal Kaluza-Klein ansatz
into three NRG-fields: a scalar identified with the Newtonian potential, a
3-vector corresponding to the gravito-magnetic vector potential and a 3-tensor.
The derivation of the Einstein-Infeld-Hoffmann Lagrangian simplifies such that
each term corresponds to a single Feynman diagram providing a clear physical
interpretation. Spin interactions are dominated by the exchange of the
gravito-magnetic field. Leading correction diagrams corresponding to the 3PN
correction to the spin-spin interaction and the 2.5PN correction to the
spin-orbit interaction are presented.Comment: 10 pages, 3 figures. v2: published version. v3: Added a computation
of Einstein-Infeld-Hoffmann in higher dimensions within our improved ClEFT
which partially confirms and partially corrects a previous computation. See
notes added at end of introductio
The role of B-1 cells in inflammation
B-1 lymphocytes exhibit unique phenotypic, ontogenic, and functional characteristics that differ from the conventional B-2 cells. B-1 cells spontaneously secrete germline-like, repertoire-skewed polyreactive natural antibody, which acts as a first line of defense by neutralizing a wide range of pathogens before launching of the adaptive immune response. Immunomodulatory molecules such as interleukin-10, adenosine, granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-35 are also produced by B-1 cells in the presence or absence of stimulation, which regulate acute and chronic inflammatory diseases. Considerable progress has been made during the past three decades since the discovery of B-1 cells, which has improved not only our understanding of their phenotypic and ontogenic uniqueness but also their role in various inflammatory diseases including influenza, pneumonia, sepsis, atherosclerosis, inflammatory bowel disease, autoimmunity, obesity and diabetes mellitus. Recent identification of human B-1 cells widens the scope of this field, leading to novel innovations that can be implemented from bench to bedside. Among the vast number of studies on B-1 cells, we have carried out a literature review highlighting current trends in the study of B-1 cell involvement during inflammation, which may result in a paradigm shift toward sustainable therapeutics in various inflammatory diseases
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