4,155 research outputs found
A Phase Space Approach to Gravitational Enropy
We examine the definition S = ln Omega as a candidate "gravitational entropy"
function. We calculate its behavior for gravitationl and density perturbations
in closed, open and flat cosmologies and find that in all cases it increases
monotonically. Using the formalism to calculate the gravitational entropy
produced during inflation gives the canonical answer. We compare the behavior
of S with the behavior of the square of the Weyl tensor. Applying the formalism
to black holes has proven more problematical.Comment: Talk delivered at South African Relativistic Cosmology Symposium, Feb
1999. Some new results over Rothman and Anninos 97. To appear in GRG, 17
page
Interface Roughening in a Hydrodynamic Lattice-Gas Model with Surfactant
Using a hydrodynamic lattice-gas model, we study interface growth in a binary
fluid with various concentrations of surfactant. We find that the interface is
smoothed by small concentrations of surfactant, while microemulsion droplets
form for large surfactant concentrations. To assist in determining the
stability limits of the interface, we calculate the change in the roughness and
growth exponents and as a function of surfactant concentration
along the interface.Comment: 4 pages with 4 embedded ps figures. Requires psfig.tex. Will appear
in PRL 14 Oct 199
White blood cell count and risk of incident lung cancer in the UK Biobank
Background The contribution of measurable immunological/inflammatory parameters to lung cancer development remains unclear, particularly among never-smokers. We investigated the relationship between total and differential white blood cell (WBC) counts and incident lung cancer risk overall and among subgroups defined by smoking status and sex in the United Kingdom (UK). Methods We evaluated 424,407 adults aged 37-73 years from the UK Biobank. Questionnaires, physical measurements, and blood were administered/collected at baseline in 2006-2010. Complete blood cell counts were measured using standard methods. Lung cancer diagnoses and histological classifications were obtained from cancer registries. Multivariable Cox regression models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of incident lung cancer in relation to quartiles (Q) of total WBC and subtype-specific counts, with Q1 as the reference. Results There were 1,493 incident cases diagnosed over an average 7-year follow-up. Overall, the highest quartile of total WBC count was significantly associated with elevated lung cancer risk (HRQ4=1.67, 95% CI:1.41-1.98). Among women, increased risks were found in current-smokers (ncases/n=244/19,464, HRQ4=2.15, 95% CI:1.46-3.16), former-smokers (ncases/n=280/69,198, HRQ4=1.75, 95% CI:1.24-2.47), and never-smokers without environmental tobacco smoke exposure (ncases/n=108/111,294, HRQ4=1.93, 95% CI:1.11-3.35). Among men, stronger associations were identified in current-smokers (ncases/n=329/22,934, HRQ4=2.95, 95% CI:2.04-4.26) and former-smokers (ncases/n= 358/71,616, HRQ4=2.38, 95% CI:1.74-3.27) but not in never-smokers. Findings were similar for lung adenocarcinoma and squamous cell carcinoma and were driven primarily by elevated neutrophil fractions. Conclusions Elevated WBCs could potentially be one of many important markers for increased lung cancer risk, especially among never-smoking women and ever-smoking men
Computer simulations of domain growth and phase separation in two-dimensional binary immiscible fluids using dissipative particle dynamics
We investigate the dynamical behavior of binary fluid systems in two
dimensions using dissipative particle dynamics. We find that following a
symmetric quench the domain size R(t) grows with time t according to two
distinct algebraic laws R(t) = t^n: at early times n = 1/2, while for later
times n = 2/3. Following an asymmetric quench we observe only n = 1/2, and if
momentum conservation is violated we see n = 1/3 at early times. Bubble
simulations confirm the existence of a finite surface tension and the validity
of Laplace's law. Our results are compared with similar simulations which have
been performed previously using molecular dynamics, lattice-gas and
lattice-Boltzmann automata, and Langevin dynamics. We conclude that dissipative
particle dynamics is a promising method for simulating fluid properties in such
systems.Comment: RevTeX; 22 pages, 5 low-resolution figures. For full-resolution
figures, connect to http://www.tcm.phy.cam.ac.uk/~ken21/tension/tension.htm
Shear-Induced Isotropic-to-Lamellar Transition in a Lattice-Gas Model of Ternary Amphiphilic Fluids
Although shear-induced isotropic-to-lamellar transitions in ternary systems
of oil, water and surfactant have been observed experimentally and predicted
theoretically by simple models for some time now, their numerical simulation
has not been achieved so far. In this work we demonstrate that a recently
introduced hydrodynamic lattice-gas model of amphiphilic fluids is well suited
for this purpose: the two-dimensional version of this model does indeed exhibit
a shear-induced isotropic-to-lamellar phase transition.Comment: 17 pages, LaTeX with epsf and REVTeX, PostScript and EPS
illustrations included. To appear in J. Phys. Cond. Ma
Holonomy invariance, orbital resonances, and kilohertz QPOs
Quantized orbital structures are typical for many aspects of classical
gravity (Newton's as well as Einstein's). The astronomical phenomenon of
orbital resonances is a well-known example. Recently, Rothman, Ellis and
Murugan (2001) discussed quantized orbital structures in the novel context of a
holonomy invariance of parallel transport in Schwarzschild geometry. We present
here yet another example of quantization of orbits, reflecting both orbital
resonances and holonomy invariance. This strong-gravity effect may already have
been directly observed as the puzzling kilohertz quasi-periodic oscillations
(QPOs) in the X-ray emission from a few accreting galactic black holes and
several neutron stars
Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.
BACKGROUND: Observational research suggests that combined therapy with Vitamin C, thiamine and hydrocortisone may reduce mortality in patients with septic shock.
METHODS AND DESIGN: The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) trial is a multicenter, double-blind, adaptive sample size, randomized, placebo-controlled trial designed to test the efficacy of combination therapy with vitamin C (1.5 g), thiamine (100 mg), and hydrocortisone (50 mg) given every 6 h for up to 16 doses in patients with respiratory or circulatory dysfunction (or both) resulting from sepsis. The primary outcome is ventilator- and vasopressor-free days with mortality as the key secondary outcome. Recruitment began in August 2018 and is ongoing; 501 participants have been enrolled to date, with a planned maximum sample size of 2000. The Data and Safety Monitoring Board reviewed interim results at N = 200, 300, 400 and 500, and has recommended continuing recruitment. The next interim analysis will occur when N = 1000. This update presents the statistical analysis plan. Specifically, we provide definitions for key treatment and outcome variables, and for intent-to-treat, per-protocol, and safety analysis datasets. We describe the planned descriptive analyses, the main analysis of the primary end point, our approach to secondary and exploratory analyses, and handling of missing data. Our goal is to provide enough detail that our approach could be replicated by an independent study group, thereby enhancing the transparency of the study.
TRIAL REGISTRATION: ClinicalTrials.gov, NCT03509350. Registered on 26 April 2018
Spinodal decomposition of off-critical quenches with a viscous phase using dissipative particle dynamics in two and three spatial dimensions
We investigate the domain growth and phase separation of
hydrodynamically-correct binary immiscible fluids of differing viscosity as a
function of minority phase concentration in both two and three spatial
dimensions using dissipative particle dynamics. We also examine the behavior of
equal-viscosity fluids and compare our results to similar lattice-gas
simulations in two dimensions.Comment: 34 pages (11 figures); accepted for publication in Phys. Rev.
The GROUSE project II: Detection of the Ks-band secondary eclipse of exoplanet HAT-P-1b
Context: Only recently it has become possible to measure the thermal emission
from hot-Jupiters at near-Infrared wavelengths using ground-based telescopes,
by secondary eclipse observations. This allows the planet flux to be probed
around the peak of its spectral energy distribution, which is vital for the
understanding of its energy budget. Aims: The aim of the reported work is to
measure the eclipse depth of the planet HAT-P-1b at 2.2micron. This planet is
an interesting case, since the amount of stellar irradiation it receives falls
in between that of the two best studied systems (HD209458 and HD189733), and it
has been suggested to have a weak thermal inversion layer. Methods: We have
used the LIRIS instrument on the William Herschel Telescope (WHT) to observe
the secondary eclipse of HATP-1b in the Ks-band, as part of our Ground-based
secondary eclipse (GROUSE) project. The observations were done in staring mode,
while significantly defocusing the telescope to avoid saturation on the K=8.4
star. With an average cadence of 2.5 seconds, we collected 6520 frames during
one night. Results: The eclipse is detected at the 4sigma level, the measured
depth being 0.109+/-0.025%. The uncertainties are dominated by residual
systematic effects, as estimated from different reduction/analysis procedures.
The measured depth corresponds to a brightness temperature of 2136+150-170K.
This brightness temperature is significantly higher than those derived from
longer wavelengths, making it difficult to fit all available data points with a
plausible atmospheric model. However, it may be that we underestimate the true
uncertainties of our measurements, since it is notoriously difficult to assign
precise statistical significance to a result when systematic effects are
important.Comment: 7 pages, 10 figures, Accepted for publication in A&
Comment on "Radiative forcings for 28 potential Archean greenhouse gases" by Byrne and Goldblatt (2014)
In the recent article by Byrne and Goldblatt, "Radiative forcing for 28 potential Archean greenhouse gases", Clim. Past. 10, 1779–1801 (2014), the authors employ the HITRAN2012 spectroscopic database to evaluate the radiative forcing of 28 Archean gases. As part of the evaluation of the status of the spectroscopy of these gases in the selected spectral region (50–1800 cm−1), the cross sections generated from the HITRAN line-by-line parameters were compared with those of the PNNL database of experimental cross sections recorded at moderate resolution. The authors claimed that for NO2, HNO3, H2CO, H2O2, HCOOH, C2H4, CH3OH and CH3Br there exist large or sometimes severe disagreements between the databases. In this work we show that for only three of these eight gases a modest discrepancy does exist between the two databases and we explain the origin of the differences. For the other five gases, the disagreements are not nearly at the scale suggested by the authors, while we explain some of the differences that do exist. In summary, the agreement between the HITRAN and PNNL databases is very good, although not perfect. Typically differences do not exceed 10 %, provided that HITRAN data exist for the bands/wavelengths of interest. It appears that a molecule-dependent combination of errors has affected the conclusions of the authors. In at least one case it appears that they did not take the correct file from PNNL (N2O4 (dimer)+ NO2 was used in place of the monomer). Finally, cross sections of HO2 from HITRAN (which do not have a PNNL counterpart) were not calculated correctly in BG, while in the case of HF misleading discussion was presented there based on the confusion by foreign or noise features in the experimental PNNL spectra
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