88 research outputs found
Una nuova attestazione del 'topos' "le citt\ue0 sono gli uomini" (Eur. fr. 828 K) nel 'Ciclope' euripideo (115-116)
This paper investigates the well-known topos \u2018cities are men\u2019, first attested in Alcaeus, and mainly focuses on the gnomic statement found in fragment 828 from Euripides\u2019 Phrixus. The comparison of this fragment with previous occurrences of the topos not only clarifies its interpretation, but also allows to propose a relative dating of the Phrixus. Moreover, the analysis pursued here identifies a new occurrence of the topos in Euripides\u2019 Cyclops (vv. 115-116), and shows that the opposition between \u3c0\u3cc\u3bb\u3b9\u3c2/\u1f10\u3c1\u3b7\u3bc\u3af\u3b1 does not have evidence military implications in this case
Il teatro dei ventagli come rappresentazione dell’immaginario orientale di Calvino
In Calvino's work East and West are strictly correlated. East, in particular, offers cues to fantastically transform themes and styles that cross through his whole creative career. In 1977 Calvino, in collaboration with the artist Toti Scialoja, worked for the production of a series of six fairy-tales to be performed on stage – L'ussaro e la luna, Lo specchio e il bersaglio, La foresta-radice-labirinto, La città abbandonata, Le porte di Bagdad, Il naufrago Valdemaro – collected under the same title Il teatro dei ventagli. Starting from the analysis of these texts, the essay wants to know how in the author's intentions there is a clear contact and dialogue with a different culture. A dialogue that Calvino’s other works have hardly emphasized in a similar keen and suggestive manner, recalling, at the same time, with few but essential lines, few and significant gestures, a linear and bare theatre, plunged in a dreamlike and fantastic atmosphere, mindful of the Oriental lesson and of the deep symbolic charge of his subjects.Oriente e Occidente sono nell’opera di Calvino strettamente intrecciati. L’Oriente, in particolare, offre spunti per trasfigurare fantasticamente, secondo moduli già sperimentati per la curatela delle Fiabe italiane o nella stesura delle Città invisibili, temi e stilemi che attraversano l’intera sua parabola creativa. Nel 1977 Calvino, in collaborazione con l’artista Toti Scialoja, lavora alla realizzazione di una serie di sei fiabe da portare in scena – L’ussaro e la luna, Lo specchio e il bersaglio, La foresta-radice-labirinto, La città abbandonata, Le porte di Bagdad, Il naufrago Valdemaro – raccolte sotto il titolo complessivo Il teatro dei ventagli. Partendo dall’analisi di questi testi, il saggio intende dimostrare come nelle intenzioni dello scrittore si sia palesato un contatto e un dialogo con una cultura diversa. Un dialogo che difficilmente altre sue opere hanno evidenziato in maniera altrettanto penetrante e suggestiva, rievocando, allo stesso tempo, con poche ma essenziali battute e pochi e significativi gesti un teatro lineare e spoglio, immerso in una atmosfera irreale e fantastica, memore della lezione orientale e dell’alta carica simbolica dei suoi oggetti
Una nuova attestazione del topos “le città sono gli uomini” (Eur. fr. 828 K) nel Ciclope euripideo (115-116)
Il contributo indaga il celebre topos ‘le città sono gli uomini’ a partire da Alceo, prestando particolare attenzione alla gnome corrispondente al fr. 828 attribuito al Frisso euripideo. Il confronto del frammento con le precedenti attestazioni del topos permette non solo di contestualizzare il frammento, ma anche di ipotizzarne una datazione. Questa analisi rintraccia una nuova occorrenza del topos nel Ciclope euripideo ai vv. 115-116, dimostrando l’assenza di implicazioni militari nell’opposizione πόλις/ἐρημία. This paper investigates the well-known topos ‘cities are men’, first attested in Alcaeus, and mainly focuses on the gnomic statement found in fragment 828 from Euripides’ Phrixus. The comparison of this fragment with previous occurrences of the topos not only clarifies its interpretation, but also allows to propose a relative dating of the Phrixus. Moreover, the analysis pursued here identifies a new occurrence of the topos in Euripides’ Cyclops (vv. 115-116), and shows that the opposition between πόλις/ἐρημία does not have evidence military implications in this case
Una matrigna in frammenti: Ino
This paper aims to investigate the role of the ‘murderous stepmother’ in Euripidean fragmentary tragedies, by focusing on Ino, Phrixus and Helle’s stepmother in Phrixus A and B, in order to outline the main features through the analysis of these fragmentary plays and the comparison with other extant plays and fragmentary ones. Specifically, the clues found for reconstructing the tragic plot are the following: Ino turns out to be non-stereotypical character, namely a stepmother who pronounces a gnome concerning stepmothers’ hostility towards stepchildren as a self-warning, not with the intention of dispelling the rumour, but to accomplish her own plan without any obstacles (fr. 824 K); the verb μηχανάομαι attested in the hypothesis of Phrixus A, a key-word of the language of deception, seems to suggest that also fr. 874 K refers to Ino; in fr. 822b K distortion in communication between Ino, who swears up and down in order to get what she wants, and her husband Athamas, deprived of authority from his wife, highlights the opposition between female vs male as a key-theme of the tragic plot; lastly, the analysis of the fragmentary data available suggests that there is a female Chorus beside Ino, who is proven to be only a temporary interlocutor and, as opposed to what usually happens, banishes the stepmother in a condition of deep solitude
Una nuova attestazione del topos “le città sono gli uomini” (Eur. fr. 828 K) nel Ciclope euripideo (115-116)
Il contributo indaga il celebre topos ‘le città sono gli uomini’ a partire da Alceo, prestando particolare attenzione alla gnome corrispondente al fr. 828 attribuito al Frisso euripideo. Il confronto del frammento con le precedenti attestazioni del topos permette non solo di contestualizzare il frammento, ma anche di ipotizzarne una datazione. Questa analisi rintraccia una nuova occorrenza del topos nel Ciclope euripideo ai vv. 115-116, dimostrando l’assenza di implicazioni militari nell’opposizione πόλις/ἐρημία.This paper investigates the well-known topos ‘cities are men’, first attested in Alcaeus, and mainly focuses on the gnomic statement found in fragment 828 from Euripides’ Phrixus. The comparison of this fragment with previous occurrences of the topos not only clarifies its interpretation, but also allows to propose a relative dating of the Phrixus. Moreover, the analysis pursued here identifies a new occurrence of the topos in Euripides’ Cyclops (vv. 115-116), and shows that the opposition between πόλις/ἐρημία does not have evidence military implications in this case
Digital Edition of Fragmentary Ancient Greek Tragedy (DEFrAG-Tragedy): idea progettuale e modello di codifica
DEFrAG-Tragedy, acronym for Digital Edition of Fragmentary Ancient Greek Tragedy, is a project for a born-digital scholarly edition of Greek tragic fragments, starting from the analysis of a sample of Euripides’ lost plays. This edition – composed of introduction, critical text, translation and commentary – is entirely XML/TEI annotated, ‘usable’, dynamic, expandable and collaborative. The present paper illustrates the structure and functions of such a critical edition (also by means of the ‘prototype on paper’ of the graphical user interface) and defines XML/TEI annotation model, namely with reference to the annotation: (a) of the structure of lost tragedies; (b) of the text, critical apparatus, translation and commentary on tragic fragments; (c) of the introduction to tragedies and of the paratextual sections
Bases moleculares da interação celular em modelos de reprodução e câncer: identificação de proteínas e mecanismos envolvidos
La interacción entre las células somáticas y entre las gametas involucra una serie de eventos moleculares que no han sido dilucidados totalmente. Nuestro grupo de investigación ha desarrollado proyectos dirigidos a profundizar el conocimiento de dichos eventos. Los estudios han comprendido el análisis de moduladores de la funcionalidad espermática (ej. efecto de la temperatura de incubación, las concentraciones del ión calcio, los anticuerpos antiespermáticos de fluidos biológicos en la motilidad, la capacitación y la exocitosis acrosomal). Asimismo, hemos caracterizado componentes del espermatozoide (ej. CaM Kinasa IV, proacrosina/acrosina) y de secreciones del tracto femenino (ej. Grp78/BiP), evaluado su rol en el desarrollo de capacidad fecundante y, en algunos casos, investigado su relación con la infertilidad. En años recientes, nuestros proyectos se han extendido al estudio de las cadherinas en eventos de adhesión celular durante la fecundación; hemos caracterizado la expresión de cadherina epitelial y neural en tejidos reproductivos y gametas y evaluado su participación en la fecundación. Dada su reconocida relevancia en el cáncer, hemos abordado estudios en diversos modelos tumorales. Nuestras investigaciones han contribuido a la comprensión de los eventos de interacción de las gametas durante la fecundación así como entre las células somáticas durante la progresión tumoral.Cell-cell interaction between somatic cells as well as gametes involves molecular events that have not been completely elucidated. Our research group has developed projects aimed at studying proteins and mechanisms participating in these interactions. Several modulators of sperm functions have been analyzed (i.e. incubation temperature, calcium ion concentration, and antisperm antibodies present in biological fluids upon sperm motility, capacitation and acrosomal exocytosis). In addition, proteins from spermatozoa (i.e. CaM Kinase IV, proacrosin/acrosin) and from secretions of the female tract (Grp78/BiP) have been characterized, and their role in the development of sperm fertilizing ability assessed. In some cases, their relationship with infertility was evaluated. In recent years, our projects have been extended to study members of the cadherin superfamily and related proteins; in particular, the expression of epithelial and neural cadherin in reproductive tissues and gametes was characterized and evidence of their participation in fertilization-related cell-cell adhesion events shown. Based on the vast evidence of the role of these proteins in tumor progression, our current research also involves studies of cancer models. Our projects have contributed to the understanding of the molecular basis of cell-cell interaction during fertilization as well as during tumor progression.A interação entre as células somáticas e entre os gametas envolve uma série de eventos moleculares que não têm sido elucidados totalmente. Nosso grupo de pesquisa tem desenvolvido projetos encaminhados a aprofundar o conhecimento de tais eventos. Os estudos têm compreendido a análise de moduladores da funcionalidade espermática (ex. efeito da temperatura de incubação, as concentrações do íon cálcio, os anticorpos antiespermáticos de fluidos biológicos na motilidade, a capacitação e a exocitose acrossomal). Do mesmo modo, caracterizamos componentes do espermatozoide (ex. CaM Kinase IV, proacrosina /acrosina) e de secreções do trato feminino (ex. Grp78/BiP), avaliamos seu papel no desenvolvimento de capacidade fecundante e, em alguns casos, investigamos sua relação com a infertilidade. Em anos recentes, nossos projetos se têm estendido ao estudo das caderinas em eventos de adesão celular durante a fecundação; temos caracterizado a expressão de caderina epitelial e neural em tecidos reprodutivos e gametas e avaliamos sua participação na fecundação. Dada sua reconhecida relevância no câncer, temos abordado estudos em diversos modelos tumorais. Nossas pesquisas têm contribuído à compreensão dos eventos de interação dos gametas durante a fecundação bem como entre as células somáticas durante a progressão tumoralFil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Furlong, Laura I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Marin Briggiler, Clara Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Veaute, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Veiga, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Matos, María L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Lapyckyj, Lara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Gabrielli, Nieves María. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Rosso, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Arzondo, María M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Edelsztein, Nadia Yasmín. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Besso, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentin
The interplay between serine proteases and caspase-1 regulates the autophagy-mediated secretion of Interleukin-1 beta in human neutrophils
Neutrophils play major roles against bacteria and fungi infections not only due to their microbicide properties but also because they release mediators like Interleukin-1 beta (IL-1β) that contribute to orchestrate the inflammatory response. This cytokine is a leaderless protein synthesized in the cytoplasm as a precursor (pro-IL-1β) that is proteolytically processed to its active isoform and released from human neutrophils by secretory autophagy. In most myeloid cells, pro-IL-1β is processed by caspase-1 upon inflammasome activation. Here we employed neutrophils from both healthy donors and patients with a gain-of-function (GOF) NLRP3-mutation to dissect IL-1β processing in these cells. We found that although caspase-1 is required for IL-1β secretion, it undergoes rapid inactivation, and instead, neutrophil serine proteases play a key role in pro-IL-1β processing. Our findings bring to light distinctive features of the regulation of caspase-1 activity in human neutrophils and reveal new molecular mechanisms that control human neutrophil IL-1β secretion.Fil: Keitelman, Irene Angélica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Shiromizu, Carolina Maiumi. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Zgajnar, Nadia Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Danielián, Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Jancic, Carolina Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Marti, Marcelo Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Fuentes, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Yancoski, Judith. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Vera Aguilar, Douglas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Rosso, David Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Goris, Verónica. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Buda, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Katsicas, María Martha. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Galigniana, Mario D.. Universidad de Buenos Aires; ArgentinaFil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Sabbione, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Trevani, Analía Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentin
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