Addressing obesity in the first 1000 days in high risk infants: Systematic review.

Early intervention is critical for addressing the challenge of childhood obesity. Yet many preventive interventions do not target infants most at risk of future overweight or obesity. This systematic review examines interventions delivered before 2 years that aim to ameliorate excess weight gain among infants at high risk of overweight or obesity, due to sociodemographic characteristics, parental weight or health status, infant feeding or health behaviours. We searched six databases for interventions: (a) delivered before age two, (b) specifically aimed at infants at high risk of childhood obesity and (c) that reported outcomes by weight status beyond 28 days. The search identified over 27,000 titles, and 49 papers from 38 studies met inclusion criteria: 10 antenatal interventions, 16 postnatal and 12 conducted both before and after birth. Nearly all targeted infant and/or maternal nutrition. Studies varied widely in design, obesity risk factors, outcomes and quality. Overall, nine interventions of varying quality reported some evidence of significantly improved child weight trajectory, although effects tended to diminish over time. Interventions that improved weight outcomes tended to engage parents for a longer period, and most offered health professional input and support. Two studies of limited quality reported significantly worse weight outcomes in the intervention group

The Effect of Water Deficits during Flowering and Seed Production on Cultivars of Subterranean Clover and Annual Medic

In improved pastures in inland southern Australia, the persistence and growth of annual pasture legumes depends in part on their ability to produce and conserve abundant seed for regeneration and production. For near-maximum seed production in spring, adequate soil water is needed for at least 70 days in subterranean clover (Trifolium subterraneum) and medic (Medicago) species. Water deficits during spring are a common occurrence, and they appear to be increasing in frequency. The effect of relatively short periods of water deficit during reproductive development has received some attention but the findings conflict. The present experiment was conducted to examine further the responses of subterranean clover to water deficits imposed during the reproductive phase, and to compare the response of medic to that of subterranean clover. The flowering of two early strains of subterranean clover (Northam, Daglish) was synchronised with two early-flowering cultivars of annual medic (Cyprus barrel medic and Harbinger strand medic). Seed production parameters were observed on four watering treatments (nil, early, mid and late deficits during the reproductive phase). Notable differences occurred between the two genera and between the water treatments in their effect on reproductive development. A highly significant interaction favouring medic was recorded between the legumes (clover, medic) and the early deficit treatment, in that the individual seed weight of medic was slightly enhanced by water stress and clover was significantly depressed. In the mid- and late-stress treatments, a significantly lower proportion of viable seed was recorded with clover versus medic. The implications of the findings for the use of adapted annual legumes are discussed. This research was supported by a Reserve Bank Research Fellowship

Soft Robotics: Cerebellar Inspired Control of Artificial Muscles

Soft robots have the potential to greatly improve human-robot interaction via intrinsically safe, compliant designs. However, new compliant materials used in soft robotics – artificial muscles – are fabricated with poor tolerances and have time-varying dynamics. Therefore, a key technical challenge is to develop adaptive control algorithms for these materials. Here, we take a novel bio-inspired approach to artificial muscle control using the adaptive filter model of the cerebellum. The cerebellum is a brain structure essential for fine-tuning human performance in a diverse range of sensory and motor tasks. Its ability to automatically calibrate and adapt to changes in a wide variety of systems using a homogenous, repeating structure suggests that cerebellar-inspired models are highly suited to controlling artificial muscles in a range of tasks. We investigate the performance of the cerebellar adaptive filter algorithm in the displacement control of a soft actuator. Experimental results demonstrate that the cerebellar algorithm is successful and learns to accurately control the time-varying dynamics of the soft actuator in real-time

One, two, or three stars? An investigation of an unusual eclipsing binary candidate undergoing dramatic period changes

We report our investigation of 1SWASP J234401.81-212229.1, a variable with a 18 461.6 s period. After identification in a 2011 search of the SuperWASP archive for main-sequence eclipsing binary candidates near the distribution's short-period limit of ~0.20 d, it was measured to be undergoing rapid period decrease in our earlier work, though later observations supported a cyclic variation in period length. Spectroscopic data obtained in 2012 with the Southern African Large Telescope did not, however, support the interpretation of the object as a normal eclipsing binary. Here, we consider three possible explanations consistent with the data: a single-star oblique rotator model in which variability results from stable cool spots on opposite magnetic poles; a two-star model in which the secondary is a brown dwarf; and a three-star model involving a low-mass eclipsing binary in a hierarchical triple system. We conclude that the latter is the most likely model

The Feeding Practices and Structure Questionnaire: development and validation of age appropriate versions for infants and toddlers

Background In order to measure and understand trajectories of parental feeding practices and their relationship with child eating and weight, it is desirable to perform assessment from infancy and across time, in age-appropriate ways. While many feeding practices questionnaires exist, none is presently available that enables tracking of feeding practices from infancy through childhood. The aim of the study was to develop a version of the Feeding Practices and Structure Questionnaire (FPSQ) for parents with infants and toddlers (< 2 years) to be used in conjunction with the original FPSQ for older children (≥2 years) to measure feeding practices related to non-responsiveness and structure across childhood. Methods Constructs and items for the FPSQ for infants and toddlers were derived from the existing and validated FPSQ for older children and supplemented by a review of the literature on infant feeding questionnaires. Following expert review, two versions of the questionnaire were developed, one for milk feeding parents and one for solid feeding parents. Data from two studies were combined (child ages 0–24 months) to test the derived constructs with Confirmatory Factor Analysis for the milk feeding (N = 731) and solid feeding (N = 611) versions. Results The milk feeding version consisted of four factors (18 items) and showed acceptable model fit and good internal reliability: ‘feeding on demand vs. feeding routine’ (α = 0.87), ‘using food to calm’ (α = 0.87), ‘persuasive feeding’ (α = 0.71), ‘parent-led feeding’ (α = 0.79). The same four factors showed acceptable model fit for the solid feeding version (21 items), likewise with good internal reliability (α = 0.74, 0.86, 0.85, 0.84 respectively). Two additional factors (13 items) were developed for the solid feeding version that appeared developmentally appropriate only for children aged 12 months or older: ‘family meal environment’ (α = 0.81) and ‘using (non-)food rewards’ (α = 0.92). The majority of factor-factor correlations were in line with those of the original FPSQ. Conclusions The FPSQ milk and solid feeding versions are the first measures specifically developed as precursors to the FPSQ to measure parental feeding practices in children < 2 years, particularly practices related to non-responsiveness and structure. Further validation in more diverse samples is required

Computational modelling of movement-related beta-oscillatory dynamics in human motor cortex

Oscillatory activity in the beta range, in human primary motor cortex (M1), shows interesting dynamics that are tied to behaviour and change systematically in disease. To investigate the pathophysiology underlying these changes, we must first understand how changes in beta activity are caused in healthy subjects. We therefore adapted a canonical (repeatable) microcircuit model used in dynamic causal modelling (DCM) previously used to model induced responses in visual cortex. We adapted this model to accommodate cytoarchitectural differences between visual and motor cortex. Using biologically plausible connections, we used Bayesian model selection to identify the best model of measured MEG data from 11 young healthy participants, performing a simple handgrip task. We found that the canonical M1 model had substantially more model evidence than the generic canonical microcircuit model when explaining measured MEG data. The canonical M1 model reproduced measured dynamics in humans at rest, in a manner consistent with equivalent studies performed in mice. Furthermore, the changes in excitability (self-inhibition) necessary to explain beta suppression during handgrip were consistent with the attenuation of sensory precision implied by predictive coding. These results establish the face validity of a model that can be used to explore the laminar interactions that underlie beta-oscillatory dynamics in humans in vivo. Our canonical M1 model may be useful for characterising the synaptic mechanisms that mediate pathophysiological beta dynamics associated with movement disorders, such as stroke or Parkinson's disease

Characteristics of Cavity-Stabilized Flames in a Supersonic Flow

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77050/1/AIAA-15095-553.pd

Ground-based detection of sodium in the transmission spectrum of exoplanet HD209458b

[Context] The first detection of an atmosphere around an extrasolar planet was presented by Charbonneau and collaborators in 2002. In the optical transmission spectrum of the transiting exoplanet HD209458b, an absorption signal from sodium was measured at a level of 0.023+-0.006%, using the STIS spectrograph on the Hubble Space Telescope. Despite several attempts, so far only upper limits to the Na D absorption have been obtained using telescopes from the ground, and the HST result has yet to be confirmed. [Aims] The aims of this paper are to re-analyse data taken with the High Dispersion Spectrograph on the Subaru telescope, to correct for systematic effects dominating the data quality, and to improve on previous results presented in the literature. [Methods] The data reduction process was altered in several places, most importantly allowing for small shifts in the wavelength solution. The relative depth of all lines in the spectra, including the two sodium D lines, are found to correlate strongly with the continuum count level in the spectra. These variations are attributed to non-linearity effects in the CCDs. After removal of this empirical relation the uncertainties in the line depths are only a fraction above that expected from photon statistics. [Results] The sodium absorption due to the planet's atmosphere is detected at >5 sigma, at a level of 0.056+-0.007% (2x3.0 Ang band), 0.070+-0.011% (2x1.5 Ang band), and 0.135+-0.017% (2x0.75 Ang band). There is no evidence that the planetary absorption signal is shifted with respect to the stellar absorption, as recently claimed for HD189733b. The measurements in the two most narrow bands indicate that some signal is being resolved.[abridged]Comment: Latex, 7 pages: accepted for publication in Astronomy & Astrophysic