Broca’s area network in language function: a pooling-data connectivity study

Background and Objective. Modern neuroimaging developments have demonstrated that cognitive functions correlate with brain networks rather than specific areas. The purpose of this paper was to analyze the connectivity of Broca's area based on language tasks. Methods. A connectivity modeling study was performed by pooling data of Broca's activation in language tasks. Fifty-seven papers that included 883 subjects in 84 experiments were analyzed. Analysis of Likelihood Estimates of pooled data was utilized to generate the map; thresholds at p < 0.01 were corrected for multiple comparisons and false discovery rate. Resulting images were co-registered into MNI standard space. Results. A network consisting of 16 clusters of activation was obtained. Main clusters were located in the frontal operculum, left posterior temporal region, supplementary motor area, and the parietal lobe. Less common clusters were seen in the sub-cortical structures including the left thalamus, left putamen, secondary visual areas and the right cerebellum. Conclusions. BA44-related networks involved in language processing were demonstrated utilizing a pooling-data connectivity study. Significance, interpretation and limitations of the results are discussed

The Elusive Role of the Left Temporal Pole (BA38) in Language: A Preliminary Meta-Analytic Connectivity Study

It has been suggested that the left temporal pole (Brodmann area 38 (BA38)) participates in diverse language functions, including semantic processing, speech comprehension, and naming. Utilizing the activation likelihood estimation (ALE), a meta-analytic connectivity study was conducted to further our understanding on the role of BA38 in language. Departing from the BrainMap functional database, 11 papers corresponding to 12 paradigms including 201 participants were selected. Initially, � \u3c 0.01 was employed as the significance level, resulting in the presence of four different activation clusters.However,when the significance level was lowered to � \u3c 0.05, sixteen activation clusters appeared, including classical language areas such as Broca’s and Wernicke’s areas. It was concluded that (1) this meta-analytic connectivity study suggests the presence of two major connection circuits involving BA38; one is related to language,while the othermay be involved in visuospatial and integrative audiovisual functions. Furthermore, (2) BA38 also contributes to various brain networks supporting linguistic processes related not only to language comprehension but also to language production

Broca\u27s area network in language function: a pooling-data connectivity study

BACKGROUND AND OBJECTIVE: Modern neuroimaging developments have demonstrated that cognitive functions correlate with brain networks rather than specific areas. The purpose of this paper was to analyze the connectivity of Broca\u27s area based on language tasks. METHODS: A connectivity modeling study was performed by pooling data of Broca\u27s activation in language tasks. Fifty-seven papers that included 883 subjects in 84 experiments were analyzed. Analysis of Likelihood Estimates of pooled data was utilized to generate the map; thresholds at p \u3c 0.01 were corrected for multiple comparisons and false discovery rate. Resulting images were co-registered into MNI standard space. RESULTS: A network consisting of 16 clusters of activation was obtained. Main clusters were located in the frontal operculum, left posterior temporal region, supplementary motor area, and the parietal lobe. Less common clusters were seen in the sub-cortical structures including the left thalamus, left putamen, secondary visual areas, and the right cerebellum. CONCLUSION: Broca\u27s area-44-related networks involved in language processing were demonstrated utilizing a pooling-data connectivity study. Significance, interpretation, and limitations of the results are discussed

Language Development across the Life Span: A Neuropsychological/Neuroimaging Perspective

Language development has been correlated with specific changes in brain development. The aim of this paper is to analyze the linguistic-brain associations that occur from birth through senescence. Findings from the neuropsychological and neuroimaging literature are reviewed, and the relationship of language changes observable in human development and the corresponding brain maturation processes across age groups are examined. Two major dimensions of language development are highlighted: naming (considered amajormeasure of lexical knowledge) and verbal fluency (regarded as amajormeasure of language production ability). Developmental changes in the brain lateralization of language are discussed, emphasizing that in early life there is an increase in functional brain asymmetry for language, but that this asymmetry changes over time, and that changes in the volume of gray and white matter are age-sensitive. The effects of certain specific variables, such as gender, level of education, and bilingualism are also analyzed. General conclusions are presented and directions for future research are suggested

Separated at birth: Rediscovering the lost emotions in Luria's Working Brain

Aleksandr Luria repeatedly emphasised the importance of emotions and the right hemisphere in his neuropsychological writings. It is surprising, therefore, that Luria's most influential book, The Working Brain, appears to lack an explicit section on these topics. This is especially notable because of a comment in the book's English-language Introduction, by Karl Pribram, referencing Luria's thoughts about precisely this material. Remarkably, it seems that Luria did write such an explicit chapter, in the original Russian edition. However, in the English-language version, the relevant sections were separated, embedded elsewhere without chapter headings, and altered, presumably following an explicit translation decision. The present paper tracks the nature of these changes and, 50 years later, presents the material for the first time translated and reunited in English, as Luria intended. After the translation, we offer a brief commentary, on the ways in which Luria's ideas were in some respects prescient, and in other respects less well-informed about the brain basis of emotions and the right hemisphere. This reunification offers an interesting time capsule on the opinions of one of neuropsychology's greatest minds, on a topic which Luria admits had, at the time, only a modest empirical foundation

“Tea for two”: the Archive of the Italian Latinity of the Middle Ages Meets the CLARIN Infrastructure

This paper aims at showing how integrating the Archive of the Italian Latinity of the Middle Ages(ALIM) into the ILC4CLARIN repository can provide mutual benefits. Making ALIM availableto a large community of scholars and researchers, on the one side, represents the first step to reduce the lack of resources for Medieval Latin in CLARIN and, on the other side, constitutesan unprecedented contribution to not only linguistic investigations, but also to the studies ofthe culture and science at the basis of the Western European society. The paper describes theadopted approach aiming to keep intact the structure of the archive and its metadata, which areboth accurately mirrored into the ILC4CLARIN repository in order to maintain existing accesspractices of the users. This structure can be found in exactly the same state within the CLARIN VLO. Finally, the paper illustrates the advantages of experimenting with some ALIM data, once introduced within the CLARIN Language Resource Switchboard service: first results are shown from the analysis of some texts with the UDPipe tool suite and the distant reading tool Voyant

Crossed-Brain Representation of Verbal and Nonverbal Functions

A74-year-old, left-handedman presentedwith a rapidly evolving loss of strength in his right leg associated with difficulty in walking. MR images disclosed an extensive left hemisphere tumor. A neuropsychological examination revealed that language was broadly normal but that the patient presented with severe nonlinguistic abnormalities, including hemineglect (both somatic and spatial), constructional defects, and general spatial disturbances; symptoms were usually associated with right hemisphere pathologies. No ideomotor apraxia was found. The implications of crossed-brain representations of verbal and nonverbal functions are analyzed

Ferulago nodosa subsp. geniculata (Guss.) Troia & Raimondo from Sicily: isolation of essential oil and evaluation of its bioactivity

Ferulago nodosa (L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area. The object of the present study is Sicilian F. nodosa subsp. geniculata (Guss.) Troia &amp; Raimondo, classified as an endemic F. nodosa subspecies. Aerial parts of this plant species were subjected to hydrodistillation to obtain an essential oil. A total of 93 compounds were identified with 2,3,6- trimethyl benzaldehyde (19.0%), spathulenol (9.0%), (E)-caryophyllene (5.4%), and caryophyllene oxide (5.4%) as the main components. The biological activities of F. nodosa essential oil were also investigated. This oil showed an interesting antioxidant potential in a 2,2′-Azino-bis(3- ethylbenzothiazoline-6-sulfonic acid) (ABTS) test (IC50 of 14.05 μg/mL). Additionally, hypoglycemic and antilipidemic effects were evaluated. Lipase enzyme was inhibited with an IC50 value of 41.99 μg/mL. Obtained data demonstrated that F. nodosa could be considered a promising source of bioactive compounds useful for the treatment and management of obesity