Economia Circolare e Sostenibilità Da modello lineare a modello circolare: implementazione di un nuovo business model. La Filiera italiana dei Materiali Compositi è un modello di business sostenibile?

Questa ricerca vuole far emergere come una filiera produttiva altamente tecnologica come quella dei materiali compositi (Aerospace - Marine-Industry-Building-Motorsport-Design), attraverso il cambiamento di modello da lineare a circolare, sia diventata una filiera CIRCOLARE SOSTENIBILE. L'intenzione è quella di fornire una visione coerente del rapporto tra Economia Circolare e modelli di business, in particolare identificando gli impatti che ha un modello basato sull'economia circolare in diverse aree di attività della filiera dei materiali compositi e provando a fornire nuovi strumenti attraverso il cambiamento di Business model , aiutando così ad anticipare lotte decisionali . In un primo capitolo verrà introdotto il concetto di Economia Circolare, le sue origini e i modelli ad oggi teorizzati; nel secondo capitolo verranno analizzati i dati della ricerca, spiegata la metodologia, illustrati i riferimenti bibliografici più importanti e vedremo le variabili individuate in letteratura come area chiave su cui far leva e intervenire per modificare la filiera da lineare a circolare ; nel terzo capitolo verrà descritta la filiera dei materiali compositi e, attraverso i cambiamenti che sono stati apportati nelle organizzazioni dell'intera filiera e alle implementazioni di nuovi processi per il riutilizzo di materiali di scarto delle produzioni e di riciclo di manufatti di materiali compositi, sarà possibile verificare l'efficacia del modello e quindi verranno esposte le conclusioni

Maxillo-Facial Morphology in Beckwith-Wiedemann Syndrome: A Preliminary Study on (epi)Genotype-Phenotype Association in Caucasians

Beckwith–Wiedemann syndrome (BWS) is a congenital overgrowth disorder caused by various (epi)genetic alterations affecting the expression of genes on chromosome 11p15. Cardinal features include abdominal wall defects, macroglossia, and cancer predisposition. Several (epi)genotype–phenotype associations were described so far, but specific studies on the evolution over time of maxillo-facial phenotype in the molecular subtypes still are scanty. The aim of this cross-sectional study was to associate maxillo-facial morphology and growth pattern with genoype in 25 Caucasian children with BWS and macroglossia. Twelve patients experienced a loss of metilation at imprinting center 2 (IC2-LoM), five had mosaic paternal uniparental isodisomy of chromosome 11 (UPD(11)pat), and eight were negative. A more marked tongue enlargement was detected in patients with IC2-LoM and negative genotype, while UPD(11)pat children showed mild macroglossia (p = 0.048). A cluster analysis did not demonstrate any specific relationship between (epi)genotype and maxillo-facial phenotype, but separated BWS patients based on their cephalometric characteristics. Children with IC2-LoM or negative genotype displayed hyperdivergence values > 30°, clockwise growth tendency, and skeletal class II into the same cluster. They had a negative prognostic score. These preliminary data suggest the need for developing individualized protocols for early monitoring of the craniofacial growth in such patients

Correlation between sensory and instrumental properties of Canestrato Pugliese slices packed in biodegradable films

This paper compares the performance of three novel biodegradable films having different gas and water vapour permeabilities to the performance of a multilayer film made of polyethylene and EVOH and having high barrier properties. As model food C. Pugliese cheese was chosen. The samples were stored for 28 days and, once a week, they were analysed using sensory and instrumental tests. Sensory data showed samples packed in high permeable biodegradable film were different from fresh cut samples after only 7 days of storage, whereas the other biodegradable films having intermediate water vapour permeability allowed the cheese to keep its sensory properties unchanged for 21 days. The only film which maintained the sensory properties of cheese, with except for texture, during all the investigated time, was the high barrier film. The sensory data are confirmed by acceptability scores

Elastin-coated biodegradable photopolymer scaffolds for tissue engineering applications

One of the main open issues in modern vascular surgery is the nonbiodegradability of implants used for stent interventions, which can lead to small caliber-related thrombosis and neointimal hyperplasia. Some new, resorbable polymeric materials have been proposed to substitute traditional stainless-steel stents, but so far they were affected by poor mechanical properties and low biocompatibility. In this respect, a new material, polypropylene fumarate (PPF), may be considered as a promising candidate to implement the development of next generation stents, due to its complete biodegradability, and excellent mechanical properties and the ease to be precisely patterned. Besides all these benefits, PPF has not been tested yet for vascular prosthesis, mainly because it proved to be almost inert, while the ability to elicit a specific biological function would be of paramount importance in such critical surgery applications. Here, we propose a biomimetic functionalization process, aimed at obtaining specific bioactivation and thus improved cell-polymer interaction. Porous PPF-based scaffolds produced by deep-UV photocuring were coated by elastin and the functionalized scaffolds were extensively characterized, revealing a stable bound between the protein and the polymer surface. Both 3T3 and HUVEC cell lines were used for in vitro tests displaying an enhancement of cells adhesion and proliferation on the functionalized scaffolds

Protein Kinase C-ζ and Protein Kinase B Regulate Distinct Steps of Insulin Endocytosis and Intracellular Sorting

We have investigated the molecular mechanisms regulating insulin internalization and intracellular sorting. Insulin internalization was decreased by 50% upon incubation of the cells with the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002. PI3K inhibition also reduced insulin degradation and intact insulin release by 50 and 75%, respectively. Insulin internalization was reduced by antisense inhibition of protein kinase C-zeta (PKCzeta) expression and by overexpression of a dominant negative PKCzeta mutant (DN-PKCzeta). Conversely, overexpression of PKCzeta increased insulin internalization as a function of the PKCzeta levels achieved in the cells. Expression of wild-type protein kinase B (PKB)-alpha or of a constitutively active form (myr-PKB) did not significantly alter insulin internalization and degradation but produced a 100% increase of intact insulin release. Inhibition of PKB by a dominant negative mutant (DN-PKB) or by the pharmacological inhibitor ML-9 reduced intact insulin release by 75% with no effect on internalization and degradation. In addition, overexpression of Rab5 completely rescued the effect of PKCzeta inhibition on insulin internalization but not that of PKB inhibition on intact insulin recycling. Indeed, PKCzeta bound to and activated Rab5. Thus, PI3K controls different steps within the insulin endocytic itinerary. PKCzeta appears to mediate the PI3K effect on insulin internalization in a Rab5-dependent manner, whereas PKB directs intracellular sorting toward intact insulin release

Cerebellar degeneration-related protein 1 expression in fibroblasts of patients affected by down syndrome

Down syndrome (DS) is the most common genetic cause of intellectual disability, resulting from lack of disjunction of sister chromatids of human chromosome 21 or not partial disjunction of chromoso..