Caracterização molecular e morfológica do agente etiológico da pinta preta em solanáceas no Brasil.

Este trabalho objetivou realizar a caracterização molecular e morfológica de isolados de Alternaria obtidos de solanáceas.Resumo 504_1

Análise da expressão diferencial de fatores de elongação e transerição de tomateiros resistentes e suscetíveis infectados com Tomato chlorotic mottle virus.

O objetivo desse trabalho foi analisar a expressão de genes da família dos fatores de elongação e de transcrição do hospedeiro durante a infecção viral por tomato chlorotic mottle virus (ToCMoV) em isolinhas de tomateiros resistentes (LAM157) e suscetíveis (Santa Clara).Resumo 253-1

Susceptibility to weathering damage and oxidative stress on soybean seeds with different lignin contents in the seed coat.

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Association between Vascular Remodelling and Necrotic Core in Coronary Arteries: Analysis by Intracoronary Ultrasound with Virtual Histology®

ABSTRACTBackgroundAnatomopathological studies suggest an association of positive vascular remodeling and vulnerable coronary plaques. The objective of this study was to verify whether there is a correlation between positive vascular remodeling and necrotic core in atherosclerotic coronary lesions.MethodsWe studied 270 cross sections obtained by Virtual Histology® in 30 patients who had positive remodeling in coronary artery segments with lesions > 50%, identified by coronary angiography. Seven cross sections were assessed per segment of coronary artery, including the cross section with the highest remodeling index, denominated cross section of interest (cross section 4).ResultsMean age was 60.8±8.8 years, 80% were male and 30% were diabetic. Unstable angina was the most frequent clinical presentation (56.6%) and the left anterior descending artery was the most analyzed vessel (43%). The vessel reference area was 15.5±4.9mm2 and the remodeling index in cross section 4 was 1.2±0.1. Repeated measures analysis of variance showed a higher percentage of necrotic core in the cross section of interest (P < 0.001). We observed a positive correlation of coronary artery remodeling and necrotic core (r = 0.79; P < 0.001).ConclusionsPositive coronary artery remodeling is associated to the presence of necrotic core, which characterizes vulnerable atherosclerotic plaques. The search for positive arterial remodeling may be a useful strategy for detecting vulnerable plaques before rupture

Crown gall caused by Agrobacterium tumefaciens species complex: a novel nursery disease of Tectona grandis in Brazil.

Made available in DSpace on 2019-04-25T00:44:08Z (GMT). No. of bitstreams: 1 Borges2018ArticleCrownGallCausedByAgrobacterium.pdf: 303222 bytes, checksum: 1be290babaac18e7abcd1ed3c612bdc5 (MD5) Previous issue date: 2018bitstream/item/196212/1/Borges2018-Article-CrownGallCausedByAgrobacterium.pd

Remote Sensing as a Tool for Agricultural Drought Alert Over the South Region of Brazil

In this study the estimative of the Combined Drought Index (CDI) to identify agricultural drought over Southern Brazil is introduced. This combined drought index is based on a combination of three indicators: Standardized Precipitation Index (SPI), Soil Moisture Anomalies (SMA) and Vegetation Health Index (VHI). The proposed CDI has four levels, watch, warning, alert I and alert II, thus benefiting an increasing degrees of severity. This CDI was applied during the first 6 months of 2020 to different study sites over Southern Brasil, representative of the crop areas. The performance of the CDI levels was assessed by comparison with risk areas. Observations show a good match between these areas and the CDI. Important crop drought events in 2020 were correctly predicted by the proposed CDI in all areas

Pathogenic variants in EP300 and ANKRD11 in patients with phenotypes overlapping Cornelia de Lange syndrome

Cornelia de Lange syndrome (CdLS), Rubinstein–Taybi syndrome (RSTS), and KBG syndrome are three distinct developmental human disorders. Variants in seven genes belonging to the cohesin pathway, NIPBL, SMC1A, SMC3, HDAC8, RAD21, ANKRD11, and BRD4, were identified in about 80% of patients with CdLS, suggesting that additional causative genes remain to be discovered. Two genes, CREBBP and EP300, have been associated with RSTS, whereas KBG results from variants in ANKRD11. By exome sequencing, a genetic cause was elucidated in two patients with clinical diagnosis of CdLS but without variants in known CdLS genes. In particular, genetic variants in EP300 and ANKRD11 were identified in the two patients with CdLS. EP300 and ANKRD11 pathogenic variants caused the reduction of the respective proteins suggesting that their low levels contribute to CdLS-like phenotype. These findings highlight the clinical overlap between CdLS, RSTS, and KBG and support the notion that these rare disorders are linked to abnormal chromatin remodeling, which in turn affects the transcriptional machinery

Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study

Background: Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. Method: Thirty-two volunteers [age (years): 36.06±7.36, BMI: 27.60±4.63 (kg/m2)] underwent assessments of body height/weight, % fat mass, fat-free mass (kg), blood pressure, and a subcutaneous adipose tissue biopsy via a surgical technique. Results: We found that NPRA mRNA was negatively associated with % fat mass (r=-0.40, R2=0.16, p=0.03) and BMI (r=-0.45, R2=0.20, p=0.01). Cohen’s f2 effect size analyses showed a small effect size between NPRA mRNA and BMI (f2=0.25). One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06). This was confirmed by Cohen’s d effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI≥30 kg/m2) and either normal weight (BMI=19-25 kg/m2; d=0.94) or overweight (BMI=25-30 kg/m2; d=1.12) individuals. Conclusions: NPRA mRNA is negatively associated with % fat mass and BMI in medication-free healthy men, suggesting a possible role of NPRA in the control of fat mass accumulatio