1,138 research outputs found
Tachyon Condensation and Black Strings
We show that under certain conditions, closed string tachyon condensation
produces a topology changing transition from black strings to Kaluza-Klein
"bubbles of nothing." This can occur when the curvature at the horizon is much
smaller than the string scale, so the black string is far from the
correspondence point when it would make a transition to an excited fundamental
string. This provides a dramatic new endpoint to Hawking evaporation. A similar
transition occurs for black p-branes, and can be viewed as a nonextremal
version of a geometric transition. Applications to AdS black holes and the AdS
soliton are also discussed.Comment: 23 pages, 1 figure, v2: references adde
Restoring the sting to metric preheating
The relative growth of field and metric perturbations during preheating is
sensitive to initial conditions set in the preceding inflationary phase. Recent
work suggests this may protect super-Hubble metric perturbations from resonant
amplification during preheating. We show that this possibility is fragile and
sensitive to the specific form of the interactions between the inflaton and
other fields. The suppression is naturally absent in two classes of preheating
in which either (1) the vacua of the non-inflaton fields during inflation are
deformed away from the origin, or (2) the effective masses of non-inflaton
fields during inflation are small but during preheating are large. Unlike the
simple toy model of a coupling, most realistic particle
physics models contain these other features. Moreover, they generically lead to
both adiabatic and isocurvature modes and non-Gaussian scars on super-Hubble
scales. Large-scale coherent magnetic fields may also appear naturally.Comment: 6 pages, 3 ps figures, RevTex, revised discussion of backreaction and
new figure. To appear Phys. Rev. D (Rapid Communication
Rapid antibody selection using surface plasmon resonance for high-speed and sensitive hazelnut lateral flow prototypes
Lateral Flow Immunoassays (LFIAs) allow for rapid, low-cost, screening of many biomolecules such as food allergens. Despite being classified as rapid tests, many LFIAs take 10–20 min to complete. For a really high-speed LFIA, it is necessary to assess antibody association kinetics. By using a label-free optical technique such as Surface Plasmon Resonance (SPR), it is possible to screen crude monoclonal antibody (mAb) preparations for their association rates against a target. Herein, we describe an SPR-based method for screening and selecting crude anti-hazelnut antibodies based on their relative association rates, cross reactivity and sandwich pairing capabilities, for subsequent application in a rapid ligand binding assay. Thanks to the SPR selection process, only the fast mAb (F-50-6B12) and the slow (S-50-5H9) mAb needed purification for labelling with carbon nanoparticles to exploit high-speed LFIA prototypes. The kinetics observed in SPR were reflected in LFIA, with the test line appearing within 30 s, almost two times faster when F-50-6B12 was used, compared with S-50-5H9. Additionally, the LFIAs have demonstrated their future applicability to real life samples by detecting hazelnut in the sub-ppm range in a cookie matrix. Finally, these LFIAs not only provide a qualitative result when read visually, but also generate semi-quantitative data when exploiting freely downloadable smartphone apps.</p
Consistent Anisotropic Repulsions for Simple Molecules
We extract atom-atom potentials from the effective spherical potentials that
suc cessfully model Hugoniot experiments on molecular fluids, e.g., and
. In the case of the resulting potentials compare very well with the
atom-atom potentials used in studies of solid-state propertie s, while for
they are considerably softer at short distances. Ground state (T=0K) and
room temperatu re calculations performed with the new potential resolve
the previous discrepancy between experimental and theoretical results.Comment: RevTeX, 5 figure
Threshold criterion for wetting at the triple point
Grand canonical simulations are used to calculate adsorption isotherms of
various classical gases on alkali metal and Mg surfaces. Ab initio adsorption
potentials and Lennard-Jones gas-gas interactions are used. Depending on the
system, the resulting behavior can be nonwetting for all temperatures studied,
complete wetting, or (in the intermediate case) exhibit a wetting transition.
An unusual variety of wetting transitions at the triple point is found in the
case of a specific adsorption potential of intermediate strength. The general
threshold for wetting near the triple point is found to be close to that
predicted with a heuristic model of Cheng et al. This same conclusion was drawn
in a recent experimental and simulation study of Ar on CO_2 by Mistura et al.
These results imply that a dimensionless wetting parameter w is useful for
predicting whether wetting behavior is present at and above the triple
temperature. The nonwetting/wetting crossover value found here is w circa 3.3.Comment: 15 pages, 8 figure
High-precision calculations of van der Waals coefficients for heteronuclear alkali-metal dimers
Van der Waals coefficients for the heteronuclear alkali-metal dimers of Li,
Na, K, Rb, Cs, and Fr are calculated using relativistic ab initio methods
augmented by high-precision experimental data. We argue that the uncertainties
in the coefficients are unlikely to exceed about 1%.Comment: 11 pages, 2 figs, graphicx.st
Consumer-friendly food allergen detection : moving towards smartphone-based immunoassays
In this critical review, we provide a comprehensive overview of immunochemical food allergen assays and detectors in the context of their user-friendliness, through their connection to smartphones. Smartphone-based analysis is centered around citizen science, putting analysis into the hands of the consumer. Food allergies represent a significant worldwide health concern and consumers should be able to analyze their foods, whenever and wherever they are, for allergen presence. Owing to the need for a scientific background, traditional laboratory-based detection methods are generally unsuitable for the consumer. Therefore, it is important to develop simple, safe, and rapid assays that can be linked with smartphones as detectors to improve user accessibility. Smartphones make excellent detection systems because of their cameras, embedded flash functions, portability, connectivity, and affordability. Therefore, this review has summarized traditional laboratory-based methods for food allergen detection such as enzyme-linked-immunosorbent assay, flow cytometry, and surface plasmon resonance, and the potential to modernize these methods by interfacing them with a smartphone readout system, based on the aforementioned smartphone characteristics. This is the first review focusing on smartphone-based food-allergen detection methods designed with the intention of being consumer-friendly. [Figure not available: see fulltext.
Transport properties of dense fluid argon
We calculate using molecular dynamics simulations the transport properties of
realistically modeled fluid argon at pressures up to and
temperatures up to . In this context we provide a critique of some newer
theoretical predictions for the diffusion coefficients of liquids and a
discussion of the Enskog theory relevance under two different adaptations:
modified Enskog theory (MET) and effective diameter Enskog theory. We also
analyze a number of experimental data for the thermal conductivity of
monoatomic and small diatomic dense fluids.Comment: 8 pages, 6 figure
Generating asymptotically plane wave spacetimes
In an attempt to study asymptotically plane wave spacetimes which admit an
event horizon, we find solutions to vacuum Einstein's equations in arbitrary
dimension which have a globally null Killing field and rotational symmetry. We
show that while such solutions can be deformed to include ones which are
asymptotically plane wave, they do not posses a regular event horizon. If we
allow for additional matter, such as in supergravity theories, we show that it
is possible to have extremal solutions with globally null Killing field, a
regular horizon, and which, in addition, are asymptotically plane wave. In
particular, we deform the extremal M2-brane solution in 11-dimensional
supergravity so that it behaves asymptotically as a 10-dimensional vacuum plane
wave times a real line.Comment: 23 pages, 1 eps figure; harvmac; v2:refs added; v3:minor comments
adde
Escherichia coli O157:H7 lineage persistence and colonization of cattle in vitro
xiii, 101 leaves ; 29 cmEscherichia coli O157:H7 is an important human pathogen that resides primarily in cattle and feedlot environments. E. coli O157:H7 can be divided into phylogenetic groups termed lineages; lineage I strains are responsible for most human illnesses. An understanding of the etiology of these lineages within cattle and the feedlot environment could allow for more effective surveillance and mitigation strategies. There were no lineage associated differences in growth or survival of E. coli O157:H7 in bovine feces at 4°C, 12°C or 25°C. Lineage I strains more readily colonized cattle jejunum tissue and a bovine colonic cell line than lineage II and intermediate type strains. Enhanced colonization of cattle by lineage I strains may increase the persistence of these strains in feedlots via re-infection and increased shedding. This outcome could increase the transmission of lineage I strains to the food supply and increase the potential for these strains to cause human illness
- …