1,337 research outputs found
Characterization of the Differentiation and Leptin Secretion Profile of Adult Stem Cells on Patterned Polylactide Films
Several issues need to be better understood before breast tissue engineering becomes a clinically viable option. One of the most important aspects is the interaction between cells and the microtopography of the implant surface. The aim of this study was to evaluate the efficacy of D1 cells, multipotent mouse bone marrow stromal precursors, in differentiating to adipocytes and to characterize their metabolic activity (lactic acid released and glucose consumed), leptin secretion and lipid production when cultured on patterned poly(L-lactide) (PLLA) films. It was determined that, by appropriate stimulation, the D1 cells displayed morphological characteristics of adipocytes and produced lipid. The results showed that a patterned surface did affect the rate of lipid production. Polynomial models were proposed to predict the amount of leptin secreted by the cells over a period of time
Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies
Chromosomal translocations that target HMGA2 at chromosome band 12q14 are seen in a variety of malignancies, notably lipoma, pleomorphic salivary adenoma and uterine leiomyoma. Although some HMGA2 fusion genes have been reported, several lines of evidence suggest that the critical pathogenic event is the expression of truncated HMGA2 isoforms. We report here the involvement of HMGA2 in six patients with myeloid neoplasia, dysplastic features and translocations or an inversion involving chromosome bands 12q13-15 and either 7p12, 8q22, 11q23, 12p11, 14q31 or 20q11. Breaks within or very close to HMGA2 were found in all six cases by molecular cytogenetic analysis, leading to overexpression of this gene as assessed by RT-PCR. Truncated transcripts consisting of HMGA2 exons 1-2 or exons 1-3 spliced to intron-derived sequences were identified in two patients, but were not seen in controls. These findings suggest that abnormalities of HMGA2 play an important and previously unsuspected role in myelodysplasia
Consistent Anisotropic Repulsions for Simple Molecules
We extract atom-atom potentials from the effective spherical potentials that
suc cessfully model Hugoniot experiments on molecular fluids, e.g., and
. In the case of the resulting potentials compare very well with the
atom-atom potentials used in studies of solid-state propertie s, while for
they are considerably softer at short distances. Ground state (T=0K) and
room temperatu re calculations performed with the new potential resolve
the previous discrepancy between experimental and theoretical results.Comment: RevTeX, 5 figure
KRAS mutation testing of tumours in adults with metastatic colorectal cancer: a systematic review and cost-effectiveness analysis
__Abstract__
Background: Bowel cancer is the third most common cancer in the UK. Most bowel cancers are initially
treated with surgery, but around 17% spread to the liver. When this happens, sometimes the liver tumour
can be treated surgically, or chemotherapy may be used to shrink the tumour to make surgery possible.
Kirsten rat sarcoma viral oncogene (KRAS) mutations make some tumours less responsive to treatment
with biological therapies such as cetuximab. There are a variety of tests available to detect these
mutations. These vary in the specific mutations that they detect, the amount of mutation they detect,
the amount of tumour cells needed, the time to give a result, the error rate and cost.
Objectives: To compare the performance and cost-effectiveness of KRAS mutation tests in differentiating
adults with metastatic colorectal cancer whose metastases are confined to the liver and are unresectable
and who may benefit from first-line treatment with cetuximab in combination with standard chemotherapy
from those who should receive standard chemotherapy alone
High-precision calculations of van der Waals coefficients for heteronuclear alkali-metal dimers
Van der Waals coefficients for the heteronuclear alkali-metal dimers of Li,
Na, K, Rb, Cs, and Fr are calculated using relativistic ab initio methods
augmented by high-precision experimental data. We argue that the uncertainties
in the coefficients are unlikely to exceed about 1%.Comment: 11 pages, 2 figs, graphicx.st
Implications of the HERA Events for the R-Parity Breaking SUSY Signals at Tevatron
The favoured R-parity violating SUSY scenarios for the anomalous HERA events
correspond to top and charm squark production via the and
couplings. In both cases the corresponding electronic
branching fractions of the squarks are expected to be . Consequently the
canonical leptoquark signature is incapable of probing these scenarios at the
Tevatron collider over most of the MSSM parameter space. We suggest alternative
signatures for probing them at Tevatron, which seem to be viable over the
entire range of MSSM parameters.Comment: 20 pages Latex file with 4 ps files containing 4 figure
Ramucirumab for Treating Advanced Gastric Cancer or Gastro-Oesophageal Junction Adenocarcinoma Previously Treated with Chemotherapy
The National Institute for Health and Care Excellence (NICE) invited the company that manufactures ramucirumab (Cyramza®, Eli Lilly and Company) to submit evidence of the clinical and cost effectiveness of the drug administered alone (monotherapy) or with paclitaxel (combination therapy) for treating adults with advanced gastric cancer or gastro-oesophageal junction (GC/GOJ) adenocarcinoma that were previously treated with chemotherapy, as part of the Institute’s single technology appraisal (STA) process. Kleijnen Systematic Reviews Ltd (KSR), in collaboration with Erasmus University Rotterdam, was commissioned to act as the Evidence Review Group (ERG). This paper describes the company’s submission, the ERG review, and NICE’s subsequent decisions. Clinical effectiveness evidence for ramucirumab monotherapy (RAM), compared with best supportive care (BSC), was based on data from the REGARD trial. Clinical effectiveness evidence for ramucirumab combination therapy (RAM + PAC), compared with paclitaxel monotherapy (PAC), was based on data from the RAINBOW trial. In addition, the company undertook a network meta-analysis (NMA) to compare RAM + PAC with BSC and docetaxel. Cost-ef
High-sensitivity troponin assays for the early rule-out or diagnosis of acute myocardial infarction in people eith acute chest pain: a systematic review and cost-effectiveness analysis
Background: Early diagnosis of acute myocardial infarction (AMI) can ensure quick and effective treatment but only 20% of adults with emergency admissions fo
Factors Influencing the Participation of Older People in Clinical Trials : Data Analysis from the MAVIS Trial
Peer reviewedPostprin
Limits on Production of Magnetic Monopoles Utilizing Samples from the DO and CDF Detectors at the Tevatron
We present 90% confidence level limits on magnetic monopole production at the
Fermilab Tevatron from three sets of samples obtained from the D0 and CDF
detectors each exposed to a proton-antiproton luminosity of
(experiment E-882). Limits are obtained for the production cross-sections and
masses for low-mass accelerator-produced pointlike Dirac monopoles trapped and
bound in material surrounding the D0 and CDF collision regions. In the absence
of a complete quantum field theory of magnetic charge, we estimate these limits
on the basis of a Drell-Yan model. These results (for magnetic charge values of
1, 2, 3, and 6 times the minimum Dirac charge) extend and improve previously
published bounds.Comment: 18 pages, 17 figures, REVTeX
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