Private Equity Success: High Returns in a Risky World

This article will be covering how a private equity firm, despite the firm’s investment preferences, can lessen their risk without negatively affecting the potential gains in their assets and capital by making the right considerations. Investing in platforms such as stocks, bonds, and real estate may offer good long term returns. A small percentage of people look to invest in private equity markets. A reason for this is because funds have high minimum investments which makes private equity more exclusive compared to many public markets. A private equity investment, in most cases, is an opportunity for higher returns, with the cost being that there is more risk involved. This is not always the case as there are stocks that are much more risky, but compared to the typical personal stock portfolio an individual has, private equity is typically seen as being riskier. Within private equity there are ways a firm can set itself up for a better chance at succeeding in the industry. There are considerations and strategies that firms can implement to increase their chances at generating less risk in their investments without negatively impacting their capital returns. These factors include, but are not limited to, the relationships that the firm builds, the decision making process within the firm, and a firm’s ability to analyze the current market. If a private equity firm considers and has a reasonable approach to these components then the firm will be well on its way to achieving the luxuries and success that every firm and investor seeks

Extractive industries and the environment:Production, pollution, and protest in global history

Resource extraction has historically caused dramatic environmental changes across the globe. Although mining and oil drilling have transformed landscapes and polluted the air and water wherever they have taken place, knowledge of how these environmental transformations have been experienced and lived in different parts of the world remains fragmentary. This special issue seeks to provide new insights into the environmental histories of resource extraction, particularly in the Global South, where extractive industries have intensified markedly since 1950. Inspired by recent environmental history scholarship, we link together analyses of imperialism, capitalism, and environmental inequality in African, Asian, and Latin American localities of resource extraction. Furthermore, drawing on the analytical framework of political ecology, we examine why protests against extractive industries did or did not occur in specific sites. Given the increasing global demand for resources and pressing current-day questions about how to live in the Anthropocene, it is timely to scrutinise production practices, pollution, and protest in global history

Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine

<p>Abstract</p> <p>Background</p> <p>Currently licensed human vaccines are subtype-specific and do not protect against pandemic H5N1 viruses. Previously, our group has reported on the construction of an influenza virus-like particle (VLP) as a new generation candidate vaccine. A mixture of influenza H5N1 VLPs representing clade 1 and 2 viruses were examined for the ability to elicit protective immunity against isolates from various clades and subclades of H5N1.</p> <p>Results</p> <p>Mice were vaccinated intramuscularly with each VLP individually, the mixture of VLPs, a mixture of purified recombinant hemagglutinin (rHA), or mock vaccinated. Elicited antibodies were assayed for the hemagglutination-inhibition (HAI) activity against clades 1 and clade 2 isolates. Mice vaccinated with each VLP individually or in a mixture had robust HAI responses against homologous viruses and HAI responses against the clade 2.3 virus, Anh/05. However, these vaccines did not induce an HAI response against the clade 2.2 virus, WS/05. Interestingly, clade 2 VLP vaccinated mice were protected against both clade 1 and 2 H5/PR8 viruses, but clade 1 VLP vaccinated mice were only protected against the clade 1 virus. Mice vaccinated with a mixture of VLPs were protected against both clade 1 and 2 viruses. In contrast, mice vaccinated with a mixture of rHA survived challenge, but lost ~15% of original weight by days 5–7 post-challenge.</p> <p>Conclusion</p> <p>These results demonstrate that a multivalent influenza VLP vaccine representing different genetic clades is a promising strategy to elicit protective immunity against isolates from emerging clades and subclades of H5N1.</p

Bayesian network analysis of nuclear acquisitions

Nuclear weapons proliferation produces a vehement global safety and security concern. Perhaps most threatening is the scenario of a rogue nation or a terrorist organization acquiring nuclear weapons where the conventional ideas of nuclear deterrence may not apply. To combat this threat, innovative tools are needed that will help to improve understanding of the pathways an organization will take in attempting to obtain nuclear weapons and in predicting those pathways based on existing evidence. In this work, a methodology was developed for predicting these pathways. This methodology uses a Bayesian network. An organization’s motivations and key resources are evaluated to produce the prior probability distributions for various pathways. These probability distributions are updated as evidence is added. The methodology is implemented through the use of the commercially available Bayesian network software package, Netica. A few simple scenarios are considered to show that the model’s predictions agree with intuition. These scenarios are also used to explore the model’s strengths and limitations. The model provides a means to measure the relative threat that an organization poses to nuclear proliferation and can identify potential pathways that an organization will likely pursue. Thus, the model can serve to facilitate preventative efforts in nuclear proliferation. The model shows that an organization’s motivations biased the various pathways more than their resources; however, resources had a greater impact on an organization’s overall chance of success. Limitations of this model are that (1) it can not account for deception, (2) it can not account for parallel weapon programs, and (3) the accuracy of the output can only be as good as the user input. This work developed the first, published, quantitative methodology for predicting nuclear proliferation with consideration for how an organization’s motivations impact their pathway probabilities

A Trivalent Virus-Like Particle Vaccine Elicits Protective Immune Responses against Seasonal Influenza Strains in Mice and Ferrets

There is need for improved human influenza vaccines, particularly for older adults who are at greatest risk for severe disease, as well as to address the continuous antigenic drift within circulating human subtypes of influenza virus. We have engineered an influenza virus-like particle (VLP) as a new generation vaccine candidate purified from the supernatants of Sf9 insect cells following infection by recombinant baculoviruses to express three influenza virus proteins, hemagglutinin (HA), neuraminidase (NA), and matrix 1 (M1). In this study, a seasonal trivalent VLP vaccine (TVV) formulation, composed of influenza A H1N1 and H3N2 and influenza B VLPs, was evaluated in mice and ferrets for the ability to elicit antigen-specific immune responses. Animals vaccinated with the TVV formulation had hemagglutination-inhibition (HAI) antibody titers against all three homologous influenza virus strains, as well as HAI antibodies against a panel of heterologous influenza viruses. HAI titers elicited by the TVV were statistically similar to HAI titers elicited in animals vaccinated with the corresponding monovalent VLP. Mice vaccinated with the TVV had higher level of influenza specific CD8+ T cell responses than a commercial trivalent inactivated vaccine (TIV). Ferrets vaccinated with the highest dose of the VLP vaccine and then challenged with the homologous H3N2 virus had the lowest titers of replicating virus in nasal washes and showed no signs of disease. Overall, a trivalent VLP vaccine elicits a broad array of immunity and can protect against influenza virus challenge

The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus

RNA folding free energy is important for the evolution and host-adaptation of the influenza virus. Human virus polymerase genes are shown to have substantially higher folding free energy values than their avian counterparts

Single-Agent Versus Combination Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer and a Performance Status of 2: Prognostic Factors and Treatment Selection Based on Two Large Randomized Clinical Trials

Purpose:Data from two randomized phase III trials were analyzed to evaluate prognostic factors and treatment selection in the first-line management of advanced non-small cell lung cancer patients with performance status (PS) 2.Patients and Methods:Patients randomized to combination chemotherapy (carboplatin and paclitaxel) in one trial and single-agent therapy (gemcitabine or vinorelbine) in the second were included in these analyses. Both studies had identical eligibility criteria and were conducted simultaneously. Comparison of efficacy and safety was performed between the two cohorts. A regression analysis identified prognostic factors and subgroups of patients that may benefit from combination or single-agent therapy.Results:Two hundred one patients were treated with combination and 190 with single-agent therapy. Objective responses were 37 and 15%, respectively. Median time to progression was 4.6 months in the combination arm and 3.5 months in the single-agent arm (p < 0.001). Median survival times were 8.0 and 6.6 months, and 1-year survival rates were 31 and 26%, respectively. Albumin <3.5 g, extrathoracic metastases, lactate dehydrogenase ≥200 IU, and 2 comorbid conditions predicted outcome. Patients with 0–2 risk factors had similar outcomes independent of treatment, whereas patients with 3–4 factors had a nonsignificant improvement in median survival with combination chemotherapy.Conclusion:Our results show that PS2 non-small cell lung cancer patients are a heterogeneous group who have significantly different outcomes. Patients treated with first-line combination chemotherapy had a higher response and longer time to progression, whereas overall survival did not appear significantly different. A prognostic model may be helpful in selecting PS 2 patients for either treatment strategy