A search for spectral hysteresis and energy-dependent time lags from X-ray and TeV gamma-ray observations of Mrk 421

Blazars are variable emitters across all wavelengths over a wide range of timescales, from months down to minutes. It is therefore essential to observe blazars simultaneously at different wavelengths, especially in the X-ray and gamma-ray bands, where the broadband spectral energy distributions usually peak. In this work, we report on three "target-of-opportunity" (ToO) observations of Mrk 421, one of the brightest TeV blazars, triggered by a strong flaring event at TeV energies in 2014. These observations feature long, continuous, and simultaneous exposures with XMM-Newton (covering X-ray and optical/ultraviolet bands) and VERITAS (covering TeV gamma-ray band), along with contemporaneous observations from other gamma-ray facilities (MAGIC and Fermi-LAT) and a number of radio and optical facilities. Although neither rapid flares nor significant X-ray/TeV correlation are detected, these observations reveal subtle changes in the X-ray spectrum of the source over the course of a few days. We search the simultaneous X-ray and TeV data for spectral hysteresis patterns and time delays, which could provide insight into the emission mechanisms and the source properties (e.g. the radius of the emitting region, the strength of the magnetic field, and related timescales). The observed broadband spectra are consistent with a one-zone synchrotron self-Compton model. We find that the power spectral density distribution at $\gtrsim 4\times 10^{-4}$ Hz from the X-ray data can be described by a power-law model with an index value between 1.2 and 1.8, and do not find evidence for a steepening of the power spectral index (often associated with a characteristic length scale) compared to the previously reported values at lower frequencies.Comment: 45 pages, 15 figure

CD4+ and CD8+ T-cell responses in bone marrow to fatty acids in high-fat diets

13 Páginas.-- 5 Figuras.--3 TablasObesity is associated with disruptions in the adaptive immune system; however, dietary fatty acids in high-fat diets (HFDs) that induce obesity have consequences that are currently unclear regarding T-cell maintenance in bone marrow (BM). C57BL/6J mice were randomly assigned to isocaloric HFDs formulated with dietary fats rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or MUFAs supplemented with eicosapentaenoic and docosahexaenoic acids for 20 weeks, followed by an analysis of the immunophenotypic feature of lymphocytes (CD3+) T and their subsets CD4+ and CD8+ T cells in spleen and BM, identification of fatty acids in BM extracellular fluid and analysis of the correspondence between fatty acids with the frequency of T-cell subsets in BM. Splenic CD3+ T cells were reduced irrespective of HFDs. In BM, CD3+ T cells were reduced after HFD-SFAs, while CD4+ T cells were increased after HFDs enriched in MUFAs and CD8+ T cells were reduced irrespective of HFDs. In BM extracellular fluid, the content of palmitic and myristic acids increased after HFD-SFAs and that of oleic acid increased after HFDs enriched in MUFAs. There was a statistical correspondence between HFD-induced changes in fatty acids in BM extracellular fluid and HFD-induced changes in the frequency of CD3+ and CD4+ T cells in BM. These findings reveal an undervalued critical role for dietary fatty acids in the selective acquisition of T-cell subsets in BM, highlighting that oleic acid existing in the surroundings of T-cell niches during HFD-induced obesity could be instrumental in the maintenance of CD4+ T cells.This work was supported by a grant AGL2016-80852-R funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe.”Peer reviewe

Joint Observation of the Galactic Center with MAGIC and CTA-LST-1

MAGIC is a system of two Imaging Atmospheric Cherenkov Telescopes (IACTs), designed to detect very-high-energy gamma rays, and is operating in stereoscopic mode since 2009 at the Observatorio del Roque de Los Muchachos in La Palma, Spain. In 2018, the prototype IACT of the Large-Sized Telescope (LST-1) for the Cherenkov Telescope Array, a next-generation ground-based gamma-ray observatory, was inaugurated at the same site, at a distance of approximately 100 meters from the MAGIC telescopes. Using joint observations between MAGIC and LST-1, we developed a dedicated analysis pipeline and established the threefold telescope system via software, achieving the highest sensitivity in the northern hemisphere. Based on this enhanced performance, MAGIC and LST-1 have been jointly and regularly observing the Galactic Center, a region of paramount importance and complexity for IACTs. In particular, the gamma-ray emission from the dynamical center of the Milky Way is under debate. Although previous measurements suggested that a supermassive black hole Sagittarius A* plays a primary role, its radiation mechanism remains unclear, mainly due to limited angular resolution and sensitivity. The enhanced sensitivity in our novel approach is thus expected to provide new insights into the question. We here present the current status of the data analysis for the Galactic Center joint MAGIC and LST-1 observations

VizieR Online Data Catalog: Mrk 421 multi-wavelength variability, 2007-2009 (Ahnen+, 2016)

Data of Mrk 421 are presented for the following instruments and bands from radio to very high energy gamma-rays: Metsahovi (37GHz), OVRO (15GHz), GASP (R band), RXTE/ASM (2-10keV), Swift/BAT(15-50keV), MAGIC (>400 GeV). The observation period is from 10th February 2007 (MJD 54141) to 23rd July 2009 (MJD 55035). Figure 2 includes the light curves of the above mentioned instruments. Figure 3 and 4 show the fractional variability F_var for these light curves of the above mentioned light curves for the whole time span (Fig. 3) and for the separate time spans P1, P2, P3 (Fig. 4). (3 data files). <P /

MUFAs in High-Fat Diets Protect against Obesity-Induced Bias of Hematopoietic Cell Lineages.

The role of dietary fatty acids in the generation of bone marrow (BM) immune cells and their trafficking to extramedullary compartments in the obesity is not yet fully understood. C57BL/6J mice are randomly assigned to isocaloric high-fat diets (HFDs) formulate with dietary fats rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs fortified with eicosapentaenoic and docosahexaenoic acids for 20 weeks, followed by profiling of the obese metabolic phenotype and immunophenotypic features of immune cells in blood, spleen, and BM. All HFDs induce an obese phenotype, but it becomes largely less disruptive after the HFDs are enriched in MUFAs, which also induce signs of granulopoiesis and an expansion of long-term hematopoietic stem and granulocyte-macrophage progenitor cells in BM. In contrast, a HFD enriched in SFAs disturbs the fitness of medullary lymphocytes and promotes monopoiesis in favor of pro-inflammatory activated subsets. The reshaping of the fatty acid pools with MUFAs from the diet serves to manipulate the generation and trafficking of immune cells that are biased during obesity. These findings reveal a novel strategy by which dietary MUFAs may be instrumental in combating HFD-induced dysfunctional immune systems

Effectiveness of the Inactivated SARS-CoV-2 (Vero Cell) Vaccine in Peruvian Health Workers

Introduction: The COVID-19 pandemic has caused a global health crisis. Vaccines against this disease have demonstrated variable efficacy and safety, although effectiveness has not been evaluated. In February 2021, the Ministry of Health of Peru approved the emergency use of the inactivated SARS-CoV-2 (Vero Cell) vaccine and initiated vaccination with health personnel at the national level. The objective of the study is to determine the effectiveness of this vaccine to reduce infections, hospitalizations, and deaths due to COVID-19. Methodology: We performed a retrospective cohort study in the period from 23 February to 26 June 2021; data were obtained from the Ministry of Health (including demographic, epidemiologic, clinical, hospital, laboratory results, deaths, and both date and quantity of vaccine doses delivered). The exposed cohort were those who received one or two vaccine doses and the non-exposed were unvaccinated. The events studied were infections, hospitalizations and deaths in the cohorts. We consider a case confirmed for COVID-19 if the test result was positive for SARS-CoV-2, via PCR or antigen test. Effectiveness was measured with incidence density ratio and risk. Confounding factors were controlled using a Poisson model with robust variance. Results: We enlisted 520,733 health workers, of whom 415,212 had two vaccine doses and 105,521 were unvaccinated. The median age was 40 years (IQR: 32&ndash;50), and 65.6% were female. The effectiveness of two vaccine doses fourteen days after application adjusted by age, sex, hospitalization, and antecedent of having the infection was 90.9% (95% CI: 85.5&ndash;94.2%); effectiveness to avoid death from COVID-19; 67.7% (60.1&ndash;73.8%) effectiveness to avoid hospitalizations; and 26.3% (23.8&ndash;28.6%) effectiveness to reduce the risk of infection by SARS-CoV-2 relative to the unvaccinated cohort. Conclusions: The inactivated SARS-CoV-2 (Vero Cell) vaccine used in two doses has an acceptable effectiveness against death and risk of hospitalization, whereas it has less effectiveness in preventing COVID-19 infection

VERITAS Detection of LS 5039 and HESS J1825-137

With 8 h of observations, VERITAS confirms the detection of two very high energy gamma-ray sources. The gamma-ray binary LS 5039 is detected with a statistical significance of 8.8 σ . The measured flux above 1 TeV is (2.5±0.4)×10−12cm−2s−1 near inferior conjunction and (7.8±2.8)×10−13cm−2s−1 near superior conjunction. The pulsar wind nebula HESS J1825-137 is detected with a statistical significance of 6.7 σ and a measured flux above 1 TeV of (3.9±0.8)×10−12cm−2s−1

Probing the Properties of the Pulsar Wind in the Gamma-Ray Binary HESS J0632+057 with NuSTAR and VERITAS Observations

HESS J0632+057 is a gamma-ray binary composed of a compact object orbiting a Be star with a period of about $315$ days. Extensive X-ray and TeV gamma-ray observations have revealed a peculiar light curve containing two peaks, separated by a dip. We present the results of simultaneous observations in hard X-rays with NuSTAR and in TeV gamma-rays with VERITAS, performed in November and December 2017. These observations correspond to the orbital phases $\phi\approx0.22$ and $0.3$, where the fluxes are rising towards the first light-curve peak. A significant variation of the spectral index from 1.77$\pm$0.05 to 1.56$\pm$0.05 is observed in the X-ray data. The multi-wavelength spectral energy distributions (SED) derived from the observations are interpreted in terms of a leptonic model, in which the compact object is assumed to be a pulsar and non-thermal radiation is emitted by high-energy electrons accelerated at the shock formed by the collision between the stellar and pulsar wind. The results of the SED fitting show that our data can be consistently described within this scenario, and allow us to estimate the magnetization of the pulsar wind at the location of the shock formation. The constraints on the pulsar-wind magnetization provided by our results are shown to be consistent with those obtained from other systems

Direct measurement of stellar angular diameters by the VERITAS Cherenkov telescopes

The angular size of a star is a critical factor in determining its basic properties$^1$. Direct measurement of stellar angular diameters is difficult: at interstellar distances stars are generally too small to resolve by any individual imaging telescope. This fundamental limitation can be overcome by studying the diffraction pattern in the shadow cast when an asteroid occults a star$^2$, but only when the photometric uncertainty is smaller than the noise added by atmospheric scintillation$^3$. Atmospheric Cherenkov telescopes used for particle astrophysics observations have not generally been exploited for optical astronomy due to the modest optical quality of the mirror surface. However, their large mirror area makes them well suited for such high-time-resolution precision photometry measurements$^4$. Here we report two occultations of stars observed by the Very Energetic Radiation Imaging Telescope Array System (VERITAS)$^5$ Cherenkov telescopes with millisecond sampling, from which we are able to provide a direct measurement of the occulted stars’ angular diameter at the ≤0.1 mas scale. This is a resolution never achieved before with optical measurements and represents an order of magnitude improvement over the equivalent lunar occultation method$^6$. We compare the resulting stellar radius with empirically derived estimates from temperature and brightness measurements, confirming the latter can be biased for stars with ambiguous stellar classifications