Virtual dielectric waveguide mode description of a high-gain free-electron laser I: Theory

A set of mode-coupled excitation equations for the slowly-growing amplitudes of dielectric waveguide eigenmodes is derived as a description of the electromagnetic signal field of a high-gain free-electron laser, or FEL, including the effects of longitudinal space-charge. This approach of describing the field basis set has notable advantages for FEL analysis in providing an efficient characterization of eigenmodes, and in allowing a clear connection to free-space propagation of the input (seeding) and output radiation. The formulation describes the entire evolution of the radiation wave through the linear gain regime, prior to the onset of saturation, with arbitrary initial conditions. By virtue of the flexibility in the expansion basis, this technique can be used to find the direct coupling and amplification of a particular mode. A simple transformation converts the derived coupled differential excitation equations into a set of coupled algebraic equations and yields a matrix determinant equation for the FEL eigenmodes. A quadratic index medium is used as a model dielectric waveguide to obtain an expression for the predicted spot size of the dominant system eigenmode, in the approximation that it is a single gaussian mode.Comment: 14 page

Hybrid modeling of relativistic underdense plasma photocathode injectors

The dynamics of laser ionization-based electron injection in the recently introduced plasma photocathode concept is analyzed analytically and with particle-in-cell simulations. The influence of the initial few-cycle laser pulse that liberates electrons through background gas ionization in a plasma wakefield accelerator on the final electron phase space is described through the use of Ammosov-Deloine-Krainov theory as well as nonadiabatic Yudin-Ivanov (YI) ionization theory and subsequent downstream dynamics in the combined laser and plasma wave fields. The photoelectrons are tracked by solving their relativistic equations of motion. They experience the analytically described transient laser field and the simulation-derived plasma wakefields. It is shown that the minimum normalized emittance of fs-scale electron bunches released in mulit-GV/m-scale plasma wakefields is of the order of 10-2 mm mrad. Such unprecedented values, combined with the dramatically increased controllability of electron bunch production, pave the way for highly compact yet ultrahigh quality plasma-based electron accelerators and light source applications

Adverse Childhood Experiences in Mothers and Their Children with Hearing Loss

This study examined the relationship between maternal and child ACEs in children with hearing loss ages 3-12. One hundred twenty-four mother-child dyads completed assessments of mother and child ACEs. Adverse cChildhood eExperiences (ACEs) were measured using the Center for Youth Wellness Adverse Childhood Experiences Questionnaire (CYW ACE-Q; Burke Harris & Renschler, 2015). Both maternal and child participants in this study reported higher levels of ACE exposure than previously reported in studies of the general population. Maternal and child ACEs were significantly correlated. White/Caucasian mothers experienced significantly fewer ACEs than mothers of other races/ethnicities. Children living in adoptive, foster, or guardianship placements experienced significantly more ACEs than children living with their biological mothers. The results of this study suggest that maternal and child ACEs are significantly correlated in children with hearing loss and their mothers, as has been found in literature on hearing mother-child dyads

The use of snowcovered area in runoff forecasts

Long-term snowcovered area data from aircraft and satellite observations have proven useful in reducing seasonal runoff forecast error on the Kern river watershed. Similar use of snowcovered area on the Kings river watershed produced results that were about equivalent to methods based solely on conventional data. Snowcovered area will be most effective in reducing forecast procedural error on watersheds with: (1) a substantial amount of area within a limited elevation range; (2) an erratic precipitation and/or snowpack accumulation pattern not strongly related to elevation; and (3) poor coverage by precipitation stations or snow courses restricting adequate indexing of water supply conditions. When satellite data acquisition and delivery problems are resolved, the derived snowcover information should provide a means for enhancing operational streamflow forecasts for areas that depend primarily on snowmelt for their water supply

A 475 years-old founder effect involving IL12RB1: a highly prevalent mutation conferring Mendelian susceptibility to mycobacterial diseases in European descendants

Mutations in IFNGR1, IFNGR2, IL12RB1, IL12B, STAT1 and NEMO result in a common clinical phenotype known as Mendelian Susceptibility to Mycobacterial Diseases (MSMD). Interleukin-12 receptor 01 (IL12R beta 1) deficiency is the most common genetic etiology for MSMD. Known mutations affecting IL12RB1 are recessively inherited and are associated with null response to both IL-12 and IL-23. Mutation IL12RB1 1623_1624delinsTT was originally described in 5 families from European origin (2 from Germany: I from Cyprus, France and Belgium). Interestingly, this same mutation was found in an unexpectedly high prevalence among IL-12R beta 1 deficient patients in Argentina: 5-out-of-6 individuals born to unrelated families carried this particular change. To determine whether mutation 1623_1624delinsTT represents a DNA mutational hotspot or a founder effect, 34 polymorphic markers internal or proximal to IL12RB1 were studied in the Argentinean and the Belgian patients. A common haplotype spanning 1.45-3.51 Mb was shared by all chromosomes carrying mutation 1623_1624delinsTT, and was not detected on 100 control chromosomes. Applying a modified likelihood-based method the age of the most recent common ancestor carrying mutation 1623_1624delinsTT was estimated in 475 years (95% CI, 175-1275), which is the time when the Spaniards initiated the colonization of the Americas. Mutation 1623_1624delinsTT represents the first founder effect described on IL-12R beta 1, the most frequently affected gene in MSMD, and affecting patients with European ancestors. The reason(s) behind the persistency of this mutation across multiple generations, its relative high prevalence, and any potential selective advantage are yet to be established