Understanding the impact of immune-mediated selection on lung cancer evolution

Summary Understanding how a tumour evolves and avoids immune recognition is paramount to improving cancer immunotherapy and patient outcome. Here we examine our recent integration of multi-region genomic, transcriptomic, epigenomic, pathology, and clinical data, highlight the need for a systematic examination of immune escape mechanisms, and discuss implications for immunotherapy approaches

Utilizing remote sensing of Thematic Mapper data to improve our understanding of estuarine processes and their influence on the productivity of estuarine-dependent fisheries

LANDSAT thematic mapper (TM) data are being used to refine and validate a stochastic spatial computer model to be applied to coastal resource management problems in Louisiana. Two major aspects of the research are: (1) the measurement of area of land (or emergent vegetation) and water and the length of the interface between land and water in TM imagery of selected coastal wetlands (sample marshes); and (2) the comparison of spatial patterns of land and water in the sample marshes of the imagery to that in marshes simulated by a computer model. In addition to activities in these two areas, the potential use of a published autocorrelation statistic is analyzed

A nod in the wrong direction : Does nonverbal feedback affect eyewitness confidence in interviews?

Eyewitnesses can be influenced by an interviewer's behaviour and report information with inflated confidence as a result. Previous research has shown that positive feedback administered verbally can affect the confidence attributed to testimony, but the effect of non-verbal influence in interviews has been given little attention. This study investigated whether positive or negative non-verbal feedback could affect the confidence witnesses attribute to their responses. Participants witnessed staged CCTV footage of a crime scene and answered 20 questions in a structured interview, during which they were given either positive feedback (a head nod), negative feedback (a head shake) or no feedback. Those presented with positive non-verbal feedback reported inflated confidence compared with those presented with negative non-verbal feedback regardless of accuracy, and this effect was most apparent when participants reported awareness of the feedback. These results provide further insight into the effects of interviewer behaviour in investigative interviewsPeer reviewedFinal Accepted Versio

deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

BACKGROUND: Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts. We develop deconstructSigs, which allows the identification of mutational signatures within a single tumor sample. RESULTS: Application of deconstructSigs identifies samples with DNA repair deficiencies and reveals distinct and dynamic mutational processes molding the cancer genome in esophageal adenocarcinoma compared to squamous cell carcinomas. CONCLUSIONS: deconstructSigs confers the ability to define mutational processes driven by environmental exposures, DNA repair abnormalities, and mutagenic processes in individual tumors with implications for precision cancer medicine

Investigating mechanisms of social support effectiveness: The case of locomotion motivation

Although social support can entail costs, individuals with a higher locomotion orientation, who are motivated to move and take action, benefit from support. In two dyadic studies, we tested whether perceived movement towards important goals would mediate the effect of recipients’ locomotion motivation on positive outcomes in support contexts. In Study 1, couples completed a 10-day diary and then recalled support interactions with their partner after the diary period. In Study 2, couples engaged in laboratory support interactions for important goals. Perceived goal movement mediated the effect of higher (vs. lower) locomotion on self-reported ratings and coder ratings of support outcomes. Higher locomotion recipients may benefit in support contexts because they perceive they can move smoothly towards their goals