Evidence-Based Research in Complementary and Alternative Medicine II: The Process of Evidence-Based Research

It is a common practice in contemporary medicine to follow stringently the scientific method in the process of validating efficacy and effectiveness of new or improved modes of treatment intervention. It follows that these complementary or alternative interventions must be validated by stringent research before they can be reliably integrated into Western medicine. The next decades will witness an increasing number of evidence-based research directed at establishing the best available evidence in complementary and alternative medicine (CAM). This second paper in this lecture series examines the process of evidence-based research (EBR) in the context of CAM. We outline the fundamental principles, process and relevance of EBR, and its implication to CAM. We underscore areas of future development in EBR. We note that the main problem of applying EBR to CAM at present has to do with the fact that the contribution of EBR can be significant only to the extent to which studies used in the process of EBR are of good quality. All too often CAM research is not of sufficient quality to warrant the generation of a consensus statement. EBR, nevertheless, can contribute to CAM by identifying current weaknesses of CAM research. We present a revised instrument to assess quality of the literature

Enhancing Software Reliability With Speculative Threads

As high-end microprocessors continue to provide more and more computing power, non-performance metrics such as security, availability, reliability, and usability have become much more important. Errors and vulnerabilities in software programs have caused significant losses of data and productivity throughout the world. Software tools are available to help identify and prevent these problems, but they are often not used in practice because of large runtime overheads and limited applicability. We believe that hardware support can make these existing tools faster and more useful, as well as provide new functionality that helps programmers write safer code

Evidence-based research in complementary and alternative medicine II: the process of evidence-based research.

It is a common practice in contemporary medicine to follow stringently the scientific method in the process of validating efficacy and effectiveness of new or improved modes of treatment intervention. It follows that these complementary or alternative interventions must be validated by stringent research before they can be reliably integrated into Western medicine. The next decades will witness an increasing number of evidence-based research directed at establishing the best available evidence in complementary and alternative medicine (CAM). This second paper in this lecture series examines the process of evidence-based research (EBR) in the context of CAM. We outline the fundamental principles, process and relevance of EBR, and its implication to CAM. We underscore areas of future development in EBR. We note that the main problem of applying EBR to CAM at present has to do with the fact that the contribution of EBR can be significant only to the extent to which studies used in the process of EBR are of good quality. All too often CAM research is not of sufficient quality to warrant the generation of a consensus statement. EBR, nevertheless, can contribute to CAM by identifying current weaknesses of CAM research. We present a revised instrument to assess quality of the literature

Compiler-directed page coloring for multiprocessors

This paper presents a new technique, compiler-directed page coloring, that eliminates conflict misses in multiprocessor applications. It enables applications to make better use of the increased aggregate cache size available in a multiprocessor. This technique uses the compiler’s knowledge of the access patterns of the parallelized applications to direct the operating system’s virtual memory page mapping strategy. We demonstrate that this technique can lead to significant performance improvements over two commonly used page mapping strategies for machines with either direct-mapped or two-way set-associative caches. We also show that it is complementary to latency-hiding techniques such as prefetching. We implemented compiler-directed page coloring in the SUIF parallelizing compiler and on two commercial operating systems. We applied the technique to the SPEC95fp benchmark suite, a representative set of numeric programs. We used the SimOS machine simulator to analyze the applications and isolate their performance bottlenecks. We also validated these results on a real machine, an eight-processor 350MHz Digital AlphaServer. Compiler-directed page coloring leads to significant performance improvements for several applications. Overall, our technique improves the SPEC95fp rating for eight processors by 8 % over Digital UNIX’s page mapping policy and by 20 % over a page coloring, a standard page mapping policy. The SUIF compiler achieves a SPEC95fp ratio of 57.4, the highest ratio to date