Observations of volcanic clouds in their first few days of atmospheric residence: The 1992 eruptions of crater peak, Mount Spurr volcano, Alaska

Satellite SO2 and ash measurements of Mount Spurr’s three 1992 volcanic clouds are compared with ground‐based observations to develop an understanding of the physical and chemical evolution of volcanic clouds. Each of the three eruptions with ratings of volcanic explosivity index three reached the lower stratosphere (14 km asl), but the clouds were mainly dispersed at the tropopause by moderate to strong (20–40 m/s) tropospheric winds. Three stages of cloud evolution were identified. First, heavy fallout of large (\u3e500 μm) pyroclasts occurred close to the volcano (vent) during and immediately after the eruptions, and the cloud resembled an advected gravity current. Second, a much larger, highly elongated region marked by a secondary‐mass maximum occurred 150–350 km downwind in at least two of the three events. This was the result of aggregate fallout of a bimodal size distribution including fine (\u3c25 \u3eμm) ash that quickly depleted the solid fraction of the volcanic cloud. For the first several hundred kilometers, the cloud spread laterally, first as an intrusive gravity current and then by wind shear and diffusion as downwind cloud transport occurred at the windspeed (during the first 18–24 h). Finally, the clouds continued to move through the upper troposphere but began decreasing in areal extent, eventually disappearing as ash and SO2 were removed by meteorological processes. Total SO2 in each eruption cloud increased by the second day of atmospheric residence, possibly because of oxidation of coerupted H2S or possibly because of the effects of sequestration by ice followed by subsequent SO2 release during fallout and desiccation of ashy hydrometeors. SO2 and volcanic ash travelled together in all the Spurr volcanic clouds. The initial (18–24 h) area expansion of the clouds and the subsequent several days of drifting were successfully mapped by both SO2 (ultraviolet) and ash (infrared) satellite imagery

‘Doing’ health policy analysis: methodological and conceptual reflections and challenges

The case for undertaking policy analysis has been made by a number of scholars and practitioners. However, there has been much less attention given to how to do policy analysis, what research designs, theories or methods best inform policy analysis. This paper begins by looking at the health policy environment, and some of the challenges to researching this highly complex phenomenon. It focuses on research in middle and low income countries, drawing on some of the frameworks and theories, methodologies and designs that can be used in health policy analysis, giving examples from recent studies. The implications of case studies and of temporality in research design are explored. Attention is drawn to the roles of the policy researcher and the importance of reflexivity and researcher positionality in the research process. The final section explores ways of advancing the field of health policy analysis with recommendations on theory, methodology and researcher reflexivity

HAZMAT. VIII. A Spectroscopic Analysis of the Ultraviolet Evolution of K Stars: Additional Evidence for K Dwarf Rotational Stalling in the First Gigayear

Efforts to discover and characterize habitable zone planets have primarily focused on Sun-like stars and M dwarfs. K stars, however, provide an appealing compromise between these two alternatives that has been relatively unexplored. Understanding the ultraviolet (UV) environment around such stars is critical to our understanding of their planets, as the UV can drastically alter the photochemistry of a planet's atmosphere. Here we present near-UV and far-UV \textit{Hubble Space Telescope}'s Cosmic Origins Spectrograph observations of 39 K stars at three distinct ages: 40 Myr, 650 Myr, and $\approx$5 Gyr. We find that the K star (0.6 -- 0.8 M$_{\odot}$) UV flux remains constant beyond 650 Myr before falling off by an order of magnitude by field age. This is distinct from early M stars (0.3 -- 0.6 M$_{\odot}$), which begin to decline after only a few hundred Myr. However, the rotation-UV activity relation for K stars is nearly identical to that of early M stars. These results may be a consequence of the spin-down stalling effect recently reported for K dwarfs, in which the spin-down of K stars halts for over a Gyr when their rotation periods reach $\approx$10 d, rather than the continuous spin down that G stars experience. These results imply that exoplanets orbiting K dwarfs may experience a stronger UV environment than thought, weakening the case for K stars as hosts of potential "super-habitable" planets.Comment: 18 pages, 7 figure

Plasmas and Controlled Nuclear Fusion

Contains reports on eight research projects split into two sections.National Science Foundation (Grant GK-1165

Plasmas and Controlled Nuclear Fusion

Contains reports on two research projects.National Science Foundation (Grants GK-57)National Science Foundation (Grants GK-614

Sequestosome‐1 (p62) expression reveals chaperone‐assisted selective autophagy in immune‐mediated necrotizing myopathies

Diffuse myofiber necrosis in the context of inflammatory myopathy is the hallmark of immune-mediated necrotizing myopathy (IMNM). We have previously shown that skeletal muscle fibers of IMNM patients may display nonrimmed vacuoles and sarcoplasmic irregularities. The dysfunctional chaperone activity has been linked to the defective assembly of skeletal muscle proteins and their degradation via lysosomes, autophagy and the proteasomal machinery. This study was undertaken to highlight a chaperone-assisted selective autophagy (CASA) pathway, functionally involved in protein homeostasis, cell stress and the immune response in skeletal muscle of IMNM patients. Skeletal muscle biopsies from 54 IMNM patients were analyzed by immunostaining, as well as by qPCR. Eight biopsies of sIBM patients served as pathological controls, and eight biopsies of nondisease control subjects were included. Alteration of autophagy was detectable in all IMNM biopsy samples highlighted via a diffuse sarcoplasmic staining pattern by p62 and LC3 independent of vacuoles. This pattern was at variance with the coarse focal staining pattern mostly confined to rimmed vacuoles in sIBM. Colocalization of p62 with the chaperone proteins HSP70 and alpha B-crystalline points to the specific targeting of misfolded proteins to the CASA machinery. Bcl2-associated athanogene 3 (BAG3) positivity of these fibers emphasizes the selectivity of autophagy processes and these fibers also express MHC class I sarcolemma. Expression of genes involved in autophagy and endoplasmic reticulum (ER) stress pathways studied here is significantly upregulated in IMNM. We highlight that vacuoles without sarcolemmal features may arise in IMNM muscle biopsies, and they must not be confounded with sIBM-specific vacuoles. Further, we show the activation of selective autophagy and emphasize the role of chaperones in this context. CASA occurs in IMNM muscle, and specific molecular pathways of autophagy differ from the ones in sIBM, with p62 as a unique identifier of this process

Plasma Electronics

Contains research objectives and reports on twelve research projects.National Science Foundation under Grant G-9330U. S. Navy (Office of Naval Research) under Contract Nonr-1841(78)U. S. NavyLincoln Laboratory, Purchase Order DDL B-00306U. S. ArmyU. S. Air Force under Air Force Contract AF19(604)-740

Plasmas and Controlled Nuclear Fusion

Contains research objectives and reports on four research projects.National Science Foundation (Grant GK-614)National Science Foundation (Grant GK-57

Amplified surface temperature response of cold, deep lakes to inter-annual air temperature variability

Summer lake surface water temperatures (LSWTs) have previously been shown to respond more rapidly to climatic warming compared to local summer surface air temperatures (SATs). In a global- scale analysis, we explore the factors underpinning the observation of an amplified response of summer LSWT to SAT variability using 20 years of satellite-derived temperatures from 144 lakes. We demonstrate that the degree of amplification in inter-annual summer LSWT is variable, and is greater for cold lakes (e.g. high latitude and high altitude), which are characterised by a short warming season, and deep lakes, that exhibit long correlation timescales of temperature anomalies due to increased thermal inertia. Such lakes are more likely to display responses in excess of local inter-annual summer SAT variability. Climatic modification of LSWT has numerous consequences for water quality and lake ecosystems, so quantifying this amplified response at a global scale is important

Plasma Electronics

Contains research objectives and reports on seven research projects.U. S. ArmyLincoln Laboratory, Purchase Order DDL B-00368U. S. Air Force under Air Force Contract AF19(604)-7400U. S. NavyNational Science Foundation (Grant G-24073)U.S. Navy (Office of Naval Research) under Contract Nonr-1841(78