Modelling dispersion effects in paper-effective thickness estimates

The structural properties of paper and cardboard are important for the design of containers and of packaging. Amcor, a Melbourne-based producer of packaging, pulp and paper products, proposed the initial problem of explaining the large discrepancies which were sometimes observed between the nominal thickness, as determined by hard platen measurements, and the effective thickness which would account for the experimentally measured values of bending stiffness. The question was also raised as to whether or not ultrasonic waves could be used to measure directly, and on-line, the effective thickness. Paper can be regarded as a fibre-composite material, with a pronounced anisotropy due to the preferential alignment of fibres in the machine direction as a consequence of the manufacturing process. The salient features of elastic (ultrasonic) wave propagation in an anisotropic plate will be presented, with an emphasis on addressing the questions raised above. In particular, it will be noted that the characterization of the first anti-symmetric (flexural) mode should provide a convenient on-line measurement of the flexural stiffness, which is the more relevant property for quality control and structural design than the effective thickness

Teleological Essentialism: Generalized

Natural/social kind essentialism is the view that natural kind categories, both living and non-living natural kinds, as well as social kinds (e.g., race, gender), are essentialized. On this view, artifactual kinds are not essentialized. Our view—teleological essentialism—is that a broad range of categories are essentialized in terms of teleology, including artifacts. Utilizing the same kinds of experiments typically used to provide evidence of essentialist thinking—involving superficial change (study 1), transformation of insides (study 2) and inferences about offspring (study 3)—we find support for the view that a broad range of categories—living natural kinds, non-living natural kinds and artifactual kinds—are essentialized in terms of teleology. Study 4 tests a unique prediction of teleological essentialism and also provides evidence that people make inferences about purposes which in turn guide categorization judgments

An evaluation of self-administering arithmetic enrichment activities for grades 4, 5, and 6

Thesis (Ed.M.)--Boston Universit

Gauge singlet scalar as inflaton and thermal relic dark matter

We show that, by adding a gauge singlet scalar S to the standard model which is nonminimally coupled to gravity, S can act both as the inflaton and as thermal relic dark matter. We obtain the allowed region of the (m_s, m_h) parameter space which gives a spectral index in agreement with observational bounds and also produces the observed dark matter density while not violating vacuum stability or nonperturbativity constraints. We show that, in contrast to the case of Higgs inflation, once quantum corrections are included the spectral index is significantly larger than the classical value (n = 0.966 for N = 60) for all allowed values of the Higgs mass m_h. The range of Higgs mass compatible with the constraints is 145 GeV < m_h < 170 GeV. The S mass lies in the range 45 GeV < ms < 1 TeV for the case of a real S scalar with large quartic self-coupling lambdas, with a smaller upper bound for smaller lambdas. A region of the parameter space is accessible to direct searches at the LHC via h-->SS, while future direct dark matter searches should be able to significantly constrain the model.Comment: 13 pages, 7 figures. Published versio

Giant electrocaloric effect around Tc_c

We use molecular dynamics with a first-principles-based shell model potential to study the electrocaloric effect (ECE) in lithium niobate, LiNbO$_3$, and find a giant electrocaloric effect along a line passing through the ferroelectric transition. With applied electric field, a line of maximum ECE passes through the zero field ferroelectric transition, continuing along a Widom line at high temperatures with increasing field, and along the instability that leads to homogeneous ferroelectric switching below $T_c$ with an applied field antiparallel to the spontaneous polarization. This line is defined as the minimum in the inverse capacitance under applied electric field. We investigate the effects of pressure, temperature and applied electric field on the ECE. The behavior we observe in LiNbO$_3$ should generally apply to ferroelectrics; we therefore suggest that the operating temperature for refrigeration and energy scavenging applications should be above the ferroelectric transition region to obtain large electrocaloric response. We find a relationship among $T_c$, the Widom line and homogeneous switching that should be universal among ferroelectrics, relaxors, multiferroics, and the same behavior should be found under applied magnetic fields in ferromagnets.Comment: 5 page

Immune dysregulation as a cause of autoinflammation in fragile X premutation carriers: link between FMRI CGG repeat number and decreased cytokine responses.

BackgroundIncreased rates of autoinflammatory and autoimmune disorders have been observed in female premutation carriers of CGG repeat expansion alleles of between 55-200 repeats in the fragile X mental retardation 1 (FMR1) gene. To determine whether an abnormal immune profile was present at a cellular level that may predispose female carriers to autoinflammatory conditions, we investigated dynamic cytokine production following stimulation of blood cells. In addition, splenocyte responses were examined in an FMR1 CGG knock-in mouse model of the fragile X premutation.MethodsHuman monocyte and peripheral blood leukocytes (PBLs) were isolated from the blood of 36 female FMR1 premutation carriers and 15 age-matched controls. Cells were cultured with media alone, LPS or PHA. In the animal model, splenocytes were isolated from 32 CGG knock-in mice and 32 wild type littermates. Splenocytes were cultured with media alone or LPS or PMA/Ionomycin. Concentrations of cytokines (GM-CSF, IL-1β, IL-6, IL-10, IL-13, IL-17, IFNγ, TNFα, and MCP-1) were determined from the supernatants of cellular cultures via Luminex multiplex assay. Additionally, phenotypic cellular markers were assessed on cells isolated from human subjects via flow cytometry.ResultsWe found decreases in cytokine production in human premutation carriers as well as in the FMR1 knock-in mice when compared with controls. Levels of cytokines were found to be associated with CGG repeat length in both human and mouse. Furthermore, T cells from human premutation carriers showed decreases in cell surface markers of activation when compared with controls.ConclusionsIn this study, FMR1 CGG repeat expansions are associated with decreased immune responses and immune dysregulation in both humans and mice. Deficits in immune responses in female premutation carriers may lead to increased susceptibility to autoimmunity and further research is warranted to determine the link between FMR1 CGG repeat lengths and onset of autoinflammatory conditions