The Lillie Mae: A Capital Investment Project In Riverboat Restoration

This case involves a proposed capital investment project. It was written for use in an introductory business finance course to present students a capital budgeting scenario involving elements of both an expansion project and a replacement project that is more complex than the usual textbook problems. It also provides students an exercise in the application of standard spreadsheet software to a common analytical problem in corporate finance, namely, a proposed capital expenditure

The Lillie Mae: A Capital Investment Project In Riverboat Restoration

This case involves a proposed capital investment project.  It was written for use in an introductory business finance course to present students a capital budgeting scenario involving elements of both an expansion project and a replacement project that is more complex than the usual textbook problems.  It also provides students an exercise in the application of standard spreadsheet software to a common analytical problem in corporate finance, namely, a proposed capital expenditure

Dynamic deformation of volcanic ejecta from the Toba caldera: Possible relevance to Cretaceous/Tertiary boundary phenomena

Plagioclase and biotite phenocrysts in ignimbrites erupted from the Toba caldera, Sumatra, show microstructures and textures indicative of shock stress levels higher than 10 GPa. Strong dynamic deformation has resulted in intense kinking in biotite and, with increasing shock intensity, the development in plagioclase of planar features, shock mosaicism, incipient recrystallization, and possible partial melting. Microstructures in quartz indicative of strong shock deformation are rare, however, and many shock lamellae, if formed, may have healed during post-shock residence in the hot ignimbrite; they might be preserved in ash falls. Peak shock stresses from explosive silicic volcanism and other endogenous processes may be high and if so would obviate the need for extraterrestrial impacts to produce all dynamically deformed structures, possibly including shock features observed near the Cretaceous/Tertiary boundary

Measurement of Solar Spectral Irradiance and Surface Ozone at Carrollton, Georgia, USA, During the Great American Eclipse on 21 August 2017

Measurements conducted at the University of West Georgia, Carrollton, Georgia, during the time of the solar eclipse of 21st August 2017 demonstrated that the integrated spectral irradiance in defined wavelength ranges in the ultraviolet and visible calculated as a fraction of the total irradiance reached a minimum at maximum obscuration of the Sun, whereas in an infrared range it was maximum. The method of analysis adopted supports the view that the changes in spectral irradiance during highly obscured partial phases is a consequence of limb darkening. In a surface ozone measurement, a minimum in ozone concentration occurred 30 +_ minutes after the instant of maximum obscuration. The observation is explained as a combined effects of change in reaction rates of photochemical generation and degradation of ozone

Fatal Outcome of Disseminated Strongyloidiasis despite Detectable Plasma and Cerebrospinal Levels of Orally Administered Ivermectin

Strongyloides stercoralis affects over 100 million people worldwide. Those people most susceptible to infection are those with an immunocompromising condition, such as cancer or human immunodeficiency virus (HIV). Local disease may spread throughout the body of the host, causing a condition termed disseminated strongyloidiasis. Standard treatment for Strongyloides stercoralis infection is oral ivermectin. We describe a patient with chronic lymphocytic leukemia diagnosed with disseminated strongyloidiasis two weeks after initial presentation. After repeated dosing of oral ivermectin with no clinical response, serum and cerebral spinal fluid (CSF) concentrations of ivermectin were measured to assess absorption. The peak serum concentration of 49.3 ng/mL correlated with a CSF concentration of 0.14 ng/mL. Despite these concentrations, the patient eventually succumbed to multi-system organ failure. We discuss the reasons for treatment failure and explore the utility of measuring ivermectin concentrations

Use of electronic patient data overview with alerts in primary care increases prescribing of lipid-lowering medications in patients with type 2 diabetes

AIMS/HYPOTHESIS: We aimed to assess whether general practices (GPs) using an electronic disease management program (DMP) with population overviews, including alerts when patients failed to receive guideline-recommended prescription medications, increased prescriptions of lipid-lowering drugs for patients with type 2 diabetes with no history of lipid-lowering treatment. METHODS: This observational study included 165 GPs that reached a high level of use of the DMP in 2012 and a control group of 135 GPs who reached a high level of use in 2013 and, hence, who were less exposed to the DMP throughout 2012. A binary measure for having been prescribed and filled lipid-lowering drugs at any time within a 12-month exposure period was derived for all patients with type 2 diabetes who did not receive a prescription for lipid-lowering drugs in the baseline year prior to the study period (i.e. 2011). Results were derived using ORs from multivariate logistic regression analyses. Subgroup stratification based on age, sex, diabetes duration, deprivation status and Charlson Comorbidity Index (CCI) score was conducted and assessed. Placebo tests were carried out to assess bias from selection to treatment. RESULTS: Patients who did not receive a prescription of lipid-lowering drugs in the year prior to being listed with GPs that used the DMP had statistically significant greater odds of receiving a prescription of lipid-lowering medications when compared with individuals who attended control GPs (OR 1.23 [95% CI 1.09, 1.38]). When the analysis period was shifted back by 2 years, no significant differences in lipid-lowering drug prescription between the two groups were found to occur, which indicates that these results were not driven by selection bias. Subgroup analyses showed that the increase in lipid-lowering drug prescriptions was primarily driven by changes among male participants (OR 1.32 [95% CI 1.12, 1.54]), patients aged 60–70 years (OR 1.40 [95% CI 1.13, 1.74]), patients with a diabetes duration of ≤5 years (OR 1.33 [95% CI 1.13, 1.56]), non-deprived patients (OR 1.25 [95% CI 1.08, 1.45]) and patients without comorbidities (CCI score = 0; OR 1.27 [95% CI 1.11, 1.45]). CONCLUSIONS/INTERPRETATION: Access to population overviews using a DMP with alerts of clinical performance measures with regard to adhering to guideline-recommended prescription of medications can increase GP prescriptions of lipid-lowering drugs. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains peer-reviewed but unedited supplementary material available at 10.1007/s00125-021-05598-x

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes.

Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown1-9. Here, by annotating the landscape of FOXA1 mutations from 3,086 human prostate cancers, we define two hotspots in the forkhead domain: Wing2 (around 50% of all mutations) and the highly conserved DNA-contact residue R219 (around 5% of all mutations). Wing2 mutations are detected in adenocarcinomas at all stages, whereas R219 mutations are enriched in metastatic tumours with neuroendocrine histology. Interrogation of the biological properties of wild-type FOXA1 and fourteen FOXA1 mutants reveals gain of function in mouse prostate organoid proliferation assays. Twelve of these mutants, as well as wild-type FOXA1, promoted an exaggerated pro-luminal differentiation program, whereas two different R219 mutants blocked luminal differentiation and activated a mesenchymal and neuroendocrine transcriptional program. Assay for transposase-accessible chromatin using sequencing (ATAC-seq) of wild-type FOXA1 and representative Wing2 and R219 mutants revealed marked, mutant-specific changes in open chromatin at thousands of genomic loci and exposed sites of FOXA1 binding and associated increases in gene expression. Of note, ATAC-seq peaks in cells expressing R219 mutants lacked the canonical core FOXA1-binding motifs (GTAAAC/T) but were enriched for a related, non-canonical motif (GTAAAG/A), which was preferentially activated by R219-mutant FOXA1 in reporter assays. Thus, FOXA1 mutations alter its pioneering function and perturb normal luminal epithelial differentiation programs, providing further support for the role of lineage plasticity in cancer progression

Development Strategy Of Hygienic Fish Marketing In Samudera Fishing Port of Bitung

Hygienic Fish Marketing (HFM) is one of the functional facilities at the fishing port provided to facilitate the marketing of fishery products. The right development strategies of HFM must take into account the potential, opportunities, constraints, and problems.  The objectives of this research are (1) to determine the condition of utilization percentage analysis of fish resources landed at HFM and to analyze the level of facility utilization at HFM, and (2) to arrange strategies and recommendations for the development of HFM at PPS Bitung. The research method used to analyze catch prediction data for the next 10 years was arithmetic analysis. Analysis of utilization percentage was used to find out the level of facility utilization at HFM.  Analysis of the development strategy of HFM at PPS Bitung used SWOT matrix analysis and QSPM analysis.  The projection of fish catch landed over the next 10 years will increase by 24.77% per year, which is predicted to be 83,549.40 tons in 2029.  The level of facility utilization is categorized as good with a value of 71.22%, that utilization level of HFM runs optimally.  Based on the analysis using the SWOT matrix and QSPM analysis, it was found that the priority strategies are the main choices in the development of HFM at PPS Bitung which increase the operational capacity of loading docks and port ponds.Keywords: TPI hygienic, Development Strategy, Internal, and External FactorAbstrakTPI Higienis merupakan salah satu fasilitas fungsional di pelabuhan perikanan yang disediakan untuk memfasilitasi kegiatan pemasaran hasil perikanan.  Strategi pengembangan TPI Higienis yang tepat harus memperhitungkan potensi, peluang, kendala, dan permasalahan. Tujuan dalam penelitian ini yaitu (1) mengetahui kondisi sumberdaya ikan yang didaratkan di TPI Higienis dan menganalisa tingkat pemanfaatan fasilitas di TPI Higienis dan (2) menyusun strategi dan rekomendasi pengembangan TPI Higienis PPS Bitung.  Metode penelitian yang digunakan untuk menganalisa data prediksi hasil tangkapan selama 10 tahun kedepan adalah analisa aritmatik. Untuk mengetahui tingkat pemanfaatan fasilitas TPI Higienis, digunakan analisis persentasi pemanfaatan. Analisa strategi pengembangan TPI Higienis PPS Bitung menggunakan analisa matriks SWOT dan analisa QSPM. Proyeksi hasil tangkapan yang didaratkan selama 10 tahun kedepan mengalami kenaikan sebesar 24,77% pertahun sehingga pada tahun 2029 produksi diprediksi sebesar 83.549,40 ton. Tingkat pemanfaatan fasilitas masuk dalam kategori baik dengan nilai 71,22% sehingga tingkat pemanfaatan TPI Higienis berjalan optimal. Berdasarkan hasil analisa menggunakan matrik SWOT dan analisa QSPM didapatkan prioritas strategi yang menjadi pilihan utama dalam strategi pengembangan TPI Higienis di PPS Bitung yakni meningkatkan kapasitas operasional dermaga bongkar dan kolam pelabuhan.Kata kunci: TPI Higienis, Strategi Pengembangan, Faktor Internal dan Eksterna