5,319 research outputs found

    The Evolution of Wing Pattern in Micropterigidae (Insecta: Lepidoptera)

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    Despite the biological importance of lepidopteran wing patterns, homologies between pattern elements in different lineages are still not understood. Though plesiomorphic wing veins influence color patterning even when not expressed in the adult wing, most studies of wing pattern evolution have focused on derived taxa with reduced venation. Here I address this gap with an examination of Micropterigidae, a very early-diverged family in which all known plesiomorphic lepidopteran veins are expressed in the adult wing. Differences between the coloration of transverse bands in Micropterix and Sabatinca suggest that homologies exist between the contrast boundaries that divide wing pattern elements. Because the wing pattern of Sabatinca doroxena very closely resembles the nymphalid groundplan when plotted onto a hypothetical nymphalid wing following the relationship between pattern and venation discussed here, it appears that the nymphalid groundplan may have originated from a Sabatinca-like wing pattern subjected to changes in wing shape

    Prospects for a Big Data History of Music

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    This position paper sets out the possibility of a musicology based on the analysis of musical-bibliographical metadata as Big Data. It outlines the work underway, as part of the AHRC-funded project A Big Data History of Music, to align seven major datasets of musical-bibliographical metadata. After discussing some of the technical challenges of data alignment, it suggests how analysis and visualization of this data might transform musicological understandings of cultural transmission and canon formation

    Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge

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    Background: Both standard and low-dose allergen provocations are an established tool in asthma research to improve our understanding of the pathophysiological mechanism of allergic asthma. However, clinical symptoms are less likely to be induced. Therefore, we designed a protocol for repetitive high-dose bronchial allergen challenges to generate clinical symptoms and airway inflammation. Methods: A total of 27 patients aged 18 to 40 years with positive skin-prick tests and mild asthma underwent repetitive high-dose allergen challenges with household dust mites for four consecutive days. Pulmonary function and exhaled NO were measured at every visit. Induced sputum was analysed before and after the allergen challenges for cell counts, ECP, IL-5, INF-γ, IL-8, and the transcription factor Foxp3. Results: We found a significant decrease in pulmonary function, an increased use of salbutamol and the development of a late asthmatic response and bronchial hyperresponsiveness, as well as a significant induction of eNO, eosinophils, and Th-2 cytokines. Repeated provocation was feasible in the majority of patients. Two subjects had severe adverse events requiring prednisolone to cope with nocturnal asthma symptoms. Conclusions: Repeated high-dose bronchial allergen challenges resulted in severe asthma symptoms and marked Th-2-mediated allergic airway inflammation. The high-dose challenge model is suitable only in an attenuated form in diseased volunteers for proof-of-concept studies and in clinical settings to reduce the risk of severe asthma exacerbations. Trial registration: ClinicalTrials.govNCT0067720

    Effects of grain shape on packing and dilatancy of sheared granular materials

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    Granular material exposed to shear shows a variety of unique phenomena: Reynolds dilatancy, positional order and orientational order effects may compete in the shear zone. We study granular packings consisting of macroscopic prolate, oblate and spherical grains and compare their behaviour. X-ray tomography is used to determine the particle positions and orientations in a cylindrical split bottom shear cell. Packing densities and the arrangements of individual particles in the shear zone are evaluated. For anisometric particles, we observe the competition of two opposite effects. One the one hand, the sheared granulate is dilated, but on the other hand the particles reorient and align with respect to the streamlines. Even though aligned cylinders in principle may achieve higher packing densities, this alignment compensates for the effect of dilatancy only partially. The complex rearrangements lead to a depression of the surface above the well oriented region while neigbouring parts still show the effect of dilation in the form of heaps. For grains with isotropic shapes, the surface remains rather flat. Perfect monodisperse spheres crystallize in the shear zone, whereby positional order partially overcompensates dilatancy effects. However, already slight deviations from the ideal monodisperse sphere shape inhibit crystallization.Comment: 12 pages, 13 figures, accepted in Soft Matte

    Library catalogue records as a research resource:introducing 'A Big Data History of Music'

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    Librarians and archivists are increasingly collecting and working with large quantities of digital data. In science, business, and now the humanities, the production and analysis of vast amounts of data (so-called ‘big data research’) have become fundamental activities. This article introduces the project A Big Data History of Music, a collaboration between Royal Holloway, University of London, and the British Library. The project has made the British Library’s catalogue records for printed and manuscript music available as open data, and has explored how the analysis and visualisation of huge numbers of bibliographic records can open new perspectives for researchers into music history. In addition to the British Library data (over a million records), the project drew on a further million bibliographic descriptions from RISM, which have also recently been released as open data. To show the challenges posed by the heterogeneous nature of the data, the article outlines the different structures of the various catalogue records used in the project, and summarises how the British Library data was cleaned and enhanced prior to its public release. Examples are given of how music-bibliographical data can be analysed and visualised, and how scholars and citizen scientists can engage with this data through hackathons, large-scale data analyses, and database construction. It is hoped this article will encourage other research libraries to consider making their catalogue records available as open data

    Evolution of shear zones in granular materials

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    The evolution of wide shear zones (or shear bands) was investigated experimentally and numerically for quasistatic dry granular flows in split bottom shear cells. We compare the behavior of materials consisting of beads, irregular grains (e.g. sand) and elongated particles. Shearing an initially random sample, the zone width was found to significantly decrease in the first stage of the process. The characteristic shear strain associated with this decrease is about unity and it is systematically increasing with shape anisotropy, i.e. when the grain shape changes from spherical to irregular (e.g. sand) and becomes elongated (pegs). The strongly decreasing tendency of the zone width is followed by a slight increase which is more pronounced for rod like particles than for grains with smaller shape anisotropy (beads or irregular particles). The evolution of the zone width is connected to shear induced density change and for nonspherical particles it also involves grain reorientation effects. The final zone width is significantly smaller for irregular grains than for spherical beads.Comment: 11 pages, 12 figures, submitted to Phys. Rev.
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