2,262 research outputs found
Contextualized property market models vs. Generalized mass appraisals: An innovative approach
The present research takes into account the current and widespread need for rational valuation methodologies, able to correctly interpret the available market data. An innovative automated valuation model has been simultaneously implemented to three Italian study samples, each one constituted by two-hundred residential units sold in the years 2016-2017. The ability to generate a "unique" functional form for the three different territorial contexts considered, in which the relationships between the influencing factors and the selling prices are specified by different multiplicative coefficients that appropriately represent the market phenomena of each case study analyzed, is the main contribution of the proposed methodology. The method can provide support for private operators in the assessment of the territorial investment conveniences and for the public entities in the decisional phases regarding future tax and urban planning policies
Bait and ditch: Consumer naïveté and salesforce incentives
We analyze a model of price competition between a transparent retailer and a deceptive one in a market where a fraction of consumers is naïve. The transparent retailer is an independent shop managed by its owner. The deceptive retailer belongs to a chain and is operated by a manager. The two retailers sell an identical base product, but the deceptive one also offers an add-on. Rational consumers never consider buying the add-on while naïve ones can be “talked” into buying it. By offering the manager a contract that pushes him to never sell the base good without the add-on, the chain can induce an equilibrium in which both retailers obtain more-than-competitive profits. The equilibrium features price dispersion and market segmentation, with the deceptive retailer targeting only naïve consumers whereas the transparent retailer serves only rational ones
Exploring the link between diabetes and pancreatic cancer
Introduction: Epidemiological studies indicate an association between type 2 diabetes and pancreatic cancer but the complex and multidirectional relationship between them remains unclear. Areas covered: We summarized epidemiological evidence on diabetes and pancreatic cancer exploring the time-risk relationship. We described mechanisms linking long-standing diabetes to pancreatic cancer. We discussed pancreatic cancer-associated diabetes and its implication in the early detection of pancreatic cancer. Expert opinion: The markedly increased risk of pancreatic cancer in patients with new-onset diabetes compared with long-standing diabetes indicates a complex and bidirectional connection, with long-standing diabetes being a predisposing factor for pancreatic cancer (increasing the risk of the malignancy 1.5- to 2-fold) and new-onset diabetes an early manifestation of the tumour. Identifying clinical features and biomarkers to distinguish pancreatic cancer-associated diabetes from type 2 diabetes is an important goal to improve management and survival of this cancer. Imaging (MRI) for middle age patients with new-onset diabetes may be considered
A Fast Deep Learning Technique for Wi-Fi-Based Human Activity Recognition
Despite recent advances, fast and reliable Human Activity Recognition in confined space is still an open problem related to many real-world applications, especially in health and biomedical monitoring. With the ubiquitous presence of Wi-Fi networks, the activity recognition and classification problems can be solved by leveraging some characteristics of the Channel State Information of the 802.11 standard. Given the well-documented advantages of Deep Learning algorithms in solving complex pattern recognition problems, many solutions in Human Activity Recognition domain are taking advantage of those models. To improve the time and precision of activity classification of time-series data stemming from Channel State Information, we propose herein a fast deep neural model encompassing concepts not only from state-of-the-art recurrent neural networks, but also using convolutional operators with added randomization. Results from real data in an experimental environment show promising results
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis
The antitumor agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (1) is a potent inhibitor of GSTP1-1, a glutathione S-transferase capable of inhibiting apoptosis by binding to JNK1 and TRAF2. We recently demonstrated that, unlike its parent compound, the benzoyl ester of 1 (compound 3) exhibits negligible reactivity towards GSH, and has a different mode of interaction with GSTP1-1. Unfortunately, 3 is susceptible to rapid metabolic hydrolysis. In an effort to improve the metabolic stability of 3, its ester group has been replaced by an amide, leading to N-(6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexyl)benzamide (4). Unlike 3, compound 4 was stable to human liver microsomal carboxylesterases, but retained the ability to disrupt the interaction between GSTP1-1 and TRAF2 regardless of GSH levels. Moreover, 4 exhibited both a higher stability in the presence of GSH and a greater cytotoxicity towards cultured A375 melanoma cells, in comparison with 1 and its analog 2. These findings suggest that 4 deserves further preclinical testing
Stochastic Model for the Motion of a Particle on an Inclined Rough Plane and the Onset of Viscous Friction
Experiments on the motion of a particle on an inclined rough plane have
yielded some surprising results. For example, it was found that the frictional
force acting on the ball is viscous, {\it i.e.} proportional to the velocity
rather than the expected square of the velocity. It was also found that, for a
given inclination of the plane, the velocity of the ball scales as a power of
its radius. We present here a one dimensional stochastic model based on the
microscopic equations of motion of the ball, which exhibits the same behaviour
as the experiments. This model yields a mechanism for the origins of the
viscous friction force and the scaling of the velocity with the radius. It also
reproduces other aspects of the phase diagram of the motion which we will
discuss.Comment: 19 pages, latex, 11 postscript figures in separate uuencoded fil
Diffusion rates of Cu adatoms on Cu(111) in the presence of an adisland nucleated at FCC or HCP sites
The surface diffusion of Cu adatoms in the presence of an adisland at FCC or
HCP sites on Cu(111) is studied using the EAM potential derived by Mishin {\it
et al.} [Phys. Rev. B {\bf 63} 224106 (2001)]. The diffusion rates along
straight (with close-packed edges) steps with (100) and (111)-type microfacets
(resp. step A and step B) are first investigated using the transition state
theory in the harmonic approximation. It is found that the classical limit
beyond which the diffusion rates follow an Arrhenius law is reached above the
Debye temperature. The Vineyard attempt frequencies and the (static) energy
barriers are reported. Then a comparison is made with the results of more
realistic classical molecular dynamic simulations which also exhibit an
Arrhenius-like behavior. It is concluded that the corresponding energy barriers
are completely consistent with the static ones within the statistical errors
and that the diffusion barrier along step B is significantly larger than along
step A. In contrast the prefactors are very different from the Vineyard
frequencies. They increase with the static energy barrier in agreement with the
Meyer-Neldel compensation rule and this increase is well approximated by the
law proposed by Boisvert {\it et al.} [Phys. Rev. Lett. {\bf 75} 469 (1995)].
As a consequence, the remaining part of this work is devoted to the
determination of static energy barriers for a large number of diffusion events
that can occur in the presence of an adisland. In particular, it is found that
the corner crossing diffusion process for triangular adislands is markedly
different for the two types of borders (A or B). From this set of results the
diffusion rates of the most important atomic displacements can be predicted and
used as input in Kinetic Monte-Carlo simulations
Disrupted Glutamate Signaling in Drosophila Generates Locomotor Rhythms in Constant Light
We have used the Cambridge Protein Trap resource (CPTI) to screen for flies whose
locomotor rhythms are rhythmic in constant light (LL) as a means of identifying circadian
photoreception genes. From the screen of ∼150 CPTI lines, we obtained seven
hits, two of which targeted the glutamate pathway, Got1 (Glutamate oxaloacetate
transaminase 1) and Gs2 (Glutamine synthetase 2). We focused on these by employing
available mutants and observed that variants of these genes also showed high
levels of LL rhythmicity compared with controls. It was also clear that the genetic
background was important with a strong interaction observed with the common and
naturally occurring timeless (tim) polymorphisms, ls-tim and s-tim. The less circadian
photosensitive ls-tim allele generated high levels of LL rhythmicity in combination with
Got1 or Gs2, even though ls-tim and s-tim alleles do not, by themselves, generate the
LL phenotype. The use of dsRNAi for both genes as well as for Gad (Glutamic acid
decarboxylase) and the metabotropic glutamate receptor DmGluRA driven by clock
gene promoters also revealed high levels of LL rhythmicity compared to controls. It
is clear that the glutamate pathway is heavily implicated in circadian photoreception.
TIM levels in Got1 and Gs2 mutants cycled and were more abundant than in controls
under LL. Got1 but not Gs2 mutants showed diminished phase shifts to 10 min light
pulses. Neurogenetic dissection of the LL rhythmic phenotype using the gal4/gal80 UAS
bipartite system suggested that the more dorsal CRY-negative clock neurons, DNs and
LNds were responsible for the LL phenotype. Immunocytochemistry using the CPTI YFP
tagged insertions for the two genes revealed that the DN1s but not the DN2 and DN3s
expressed Got1 and Gs2, but expression was also observed in the lateral neurons, the
LNds and s-LNvs. Expression of both genes was also found in neuroglia. However,
downregulation of glial Gs2 and Got1 using repo-gal4 did not generate high levels
of LL rhythmicity, so it is unlikely that this phenotype is mediated by glial expression.
Our results suggest a model whereby the DN1s and possibly CRY-negative LNds use
glutamate signaling to supress the pacemaker s-LNvs in LL
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