Meu escritório é no bar : a trajetória de quem encontra sustento pelos bares de Brasília

Trabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Faculdade de Comunicação, Curso de Comunicação Organizacional, 2017.Este memorial relata os objetivos, o aporte teórico, os procedimentos metodológicos e as etapas de produção do documentário de curta-metragem: “Meu escritório é no bar: a trajetória de quem encontra sustento pelos bares de Brasília”. O vídeo pretende explorar a trajetória de vida de vendedores ambulantes que circulam à noite pelos bares da Asa Norte de Brasília, para quebrar estereótipos e contribuir para o melhor conhecimento da cidade.This memorial reports on the objectives, theoretical contribution, methodological procedures and stages of production of the short documentary: "My office is in the bar: the trajectory of those who find sustenance through the bars of Brasilia." The video intends to explore the life trajectory of street vendors that circulate at night in the bars of Asa Norte de Brasilia, to break stereotypes and contribute to the better knowledge of the city

A promoção de uma educação multicultural: o papel da literatura infantil

Numa sociedade cada vez mais multicultural, e numa altura em que tanto se fala em “crise de valores” e em falta de hábitos de leitura, sentimos necessidade de perceber em que medida a leitura de narrativas de literatura infantil pode ajudar na formação, enquanto pessoa, dos nossos jovens alunos. Na verdade, o desafio da multiculturalidade está presente na sociedade atual, nomeadamente na escola, onde convivem crianças das mais diversas culturas e onde os docentes terão de desenvolver práticas pedagógicas conducentes à inclusão e ao sucesso educativo de todos os alunos. Assim, parece-nos que as narrativas de literatura infantil poderão constituir-se como um recurso pedagógico indispensável. Neste sentido, pareceu-nos pertinente e atual estudar um corpus de narrativas de literatura infantil, inseridas na obra intitulada Contos de um Mundo com Esperança, encomendada pela Amnistia Internacional na sua Secção Portuguesa, textos estes direcionados para a promoção de uma educação multicultural. Através do nosso corpus tentámos compreender que comportamentos, paradigmas e valores estes textos transmitem aos leitores mais novos, que certamente contribuem para a sua formação integral enquanto membros de uma sociedade. De facto, ao longo do estudo, percebemos que as preocupações encerradas nos textos encomendados manifestam um forte potencial educativo, podendo ser a obra Contos de um Mundo com Esperança considerada um livro multicultural. /ABSTRACT - In an increasingly multicultural society where "crisis of values" and lack of reading habits are daily concerns, perceiving and understanding how reading narratives of children literature can help the young students' development, as human beings, assumes a relevant role in education. In fact, the challenge of being multicultural is present in the society of today, namely at the school, where children of the most diverse cultures coexist and socialize and where teachers have to develop pedagogical practices conducive to the inclusion and to the educative success of all students. For that reason, it seems that narratives of children literature may constitute a relevant pedagogical resource. In this sense, it appeared to be pertinent and currently relevant to study a corpus titled “Contos de um Mundo com Esperança” (Stories of a World with Hope) asked by the Portuguese Section of the International Amnesty. The corpus was developed to fit the young people's characteristics and needs and includes a significant amount of children literature texts directed to a multicultural education. We have tried, through the corpus, to identify and understand what behaviours, paradigms and values those texts may transmit to the young readers and certainly contribute to their integral personal development while members of a society. In fact, throughout of the study, it Was possible to perceive that the concerns embedded in the texts reveal a strong educative potential which may make the “Contos de um Mundo com Esperança ” (Stories of a World with Hope) a multicultural book

Handle assessment of tissue paper

Handle has a primary influence with nearly everything surrounding us as it gives the essential information to interact with our neighbourhood. The need to know how this affects our decisions is fundamental and leads to the study and understanding of this human sense. Tissues paper is one of the most common elements of interaction in the day-to-day human life; it can be produced in various ways leading to different textures which can transmit various sensations. The FRICTORQ® is a laboratory equipment developed by the authors to measure the friction coefficient in fabrics, to enable a quantitative assessment of touch/handle, in order to predict the comfort behaviour of 2D/3D structures when used or touched by humans.In the present study the existence of a correlation between a subjective assessment and the objective measurement of different parameters analysed in paper tissues has been investigated

Study, design and development of a new add-on function for the FRICTORQ® - Friction Test Instrument

The assessment of handle properties is of utmost importance in materials in our everyday life. There is a wide range of materials there are used in contact with the human skin, which may cause several unpleasant skin reactions. The FRICTORQ® is a laboratory equipment developed by the authors to measure the friction coefficient in fabrics, to enable a quantitative assessment of touch/handle, in order to predict the comfort behaviour of 2D/3D structures when used or touched by humans. In a further development, the FRICTORQ® was redesigned to accommodate a new testing kit function to determine the friction coefficient of fabrics in a liquid environment. This new design will be explained and the results obtained while testing different swimwear fabrics and hospital garments will be also presented and discussed

FRICTORQ: evaluation of friction coefficient in the presence of cosmetic creams

There are numerous applications in which products or materials are in contact with the human body, including the skin, such as clothing, fine papers and even cosmetics. In this sense, and with special emphasis on cosmetic products, there are several parameters for assessing its quality and applicability. The coefficient of friction is one of these parameters for the objective assessment of a concept commonly known by touch. This paper aims to review the main developments that led to the redesign of FRICTORQ device for measuring the coefficient of friction of cosmetic creams, and the first preliminary tests carried out with cosmetic products are also presented, analysed and discussed. It was determined that the friction coefficient of a moisturizing cream is higher than the one obtained for an exfoliating cream

NOTCH1-related leukoencephalopathy: a novel variant and literature review

Background: NOTCH1-related leukoencephalopathy is a new diagnostic entity linked to heterozygous gain-of-function variants in NOTCH1 that neuroradiologically shows some overlap with the inflammatory microangiopathy Aicardi-Goutières syndrome (AGS). Aim: To report a 16-year-old boy harbouring a novel NOTCH1 mutation who presented neuroradiological features suggestive of enhanced type I interferon signalling. We describe 5-years of follow-up and review the current literature on NOTCH1-related leukoencephalopathy. Methods: Clinical evaluation, standardized scales (SPRS, SARA, CBCL, CDI-2:P, WISCH-IV and VABS-2) and neuroradiological studies were performed, as well as blood DNA analysis. For the literature review, a search was performed on Pubmed, Scopus and Web of Science, up to December 2023 using the following text word search strategy: (NOTCH1) AND (leukoencephalopathy). Results: Our patient presents clinical features consistent with other reported cases with NOTCH1 mutations but is among the minority of patients with an onset after infancy. During the 5-year follow-up, we observed an increase in the severity of spasticity and ataxia. However, at the age of 16 years, our proband is still ambulatory. As for other reported patients, he manifests psychiatric features, ranging from hyperactivity during childhood, to anxiety and depression during adolescence. The neuroradiological picture remained essentially stable over 5 years. In addition to the typical findings of leukoencephalopathy with cysts and calcifications already described, we report the presence of T2-hyperintensity and T1-hypotensity of the transverse pontine fibres, enhancement in the periventricular white matter after gadolinium administration, and decreased NAA and Cho peaks in the periventricular white matter on MRS. We identified a novel heterozygous variant in NOTCH1 (c.4788_4799dup), a frame insertion located in extracellular negative regulatory region (NRR)-domain as in previously published cases. Blood interferon signalling was not elevated compared to controls. Conclusions: This case provides further data on a new diagnostic entity i.e. NOTCH1-related leukoencephalopathy. By describing a standardized 5-year follow-up in one case, and reviewing the other patients described to date, we outline recommendations relating to monitoring in this illness, emphasizing the importance of psychiatric and gastroenterological surveillance alongside neurological and neuropsychological management. Studies are needed to better understand the factors influencing disease onset and severity, which are heterogeneous

Xanthone biosynthesis and accumulation in calli and suspended cells of Hypericum androsaemum

Calli and suspended cells of Hypericum androsaemum accumulated high levels of 1,3,5,6 and 1,3,6,7 oxygenated xanthones. The major compounds include simple oxygenated xanthones or derivatives with prenyl, pyran or methoxyl groups, four of them being new natural compounds. A hypothetical biosynthetic scheme is proposed based on the isolated compounds and statistical analysis. Xanthone accumulation was influenced greatly by medium factors, namely hormone supplementation. Calli grown with 4.5 mM a-naphtaleneacetic acid (NAA) 2.3 mM kinetin (KIN) had the highest specific xanthone production (1.3% biomass dry weight (DW)), whereas suspended cells grown in similar medium accumulated a lower amount (0.87% DW). Calli displayed a negative linear relationship between total xanthone accumulation and NAA concentration, in the range of 4.5–22.5 mM. However, in this range the xanthone 1,3,6,7:1,3,5,6 ratio and the biomass production showed a positive linear relationship with NAA concentration. Substitution of 4.5 mM of NAA by the same molar amount of 2,4-dichlorophenoxyacetic acid (2,4-D), in the presence of 2.3 mM of KIN, caused a decrease in xanthone accumulation in calli. The use of N6-benzyladenine (BA) instead of KIN reduced xanthone production, independently of the auxin used. This effect was attenuated when both hormones were present.Fundação para a Ciência e a Tecnologia (FCT

The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats

In this study we evaluate the biosafety and bioactivity (antioxidant potential) of a traditional water infusion (tea) of common sage (Salvia officinalis L.) in vivo in mice and rats by quantification of plasma transaminase activities and liver GST and GR enzyme activities. The replacement of water by sage tea for 14 days in the diet of rodents did not affect the body weight and food consumption and did not induce liver toxicity. On the other hand, a significant increase of liver GST activity was observed in rats (24%) and mice (10%) of sage drinking groups. The antioxidant potential of sage tea drinking was also studied in vitro in a model using rat hepatocytes in primary culture. The replacement of drinking water with sage tea in the rats used as hepatocyte donors resulted in an improvement of the antioxidant status of rat hepatocytes in primary culture, namely a significant increase in GSH content and GST activity after 4 hours of culture. When these hepatocyte cultures were exposed to 0.75 or 1 mM of tert-butyl hydroperoxide for 1 hour, some protection against lipid peroxidation and GSH depletion was conferred by sage tea drinking. However, the cell death induced by t-BHP as shown by LDH leakage was not different from that observed in cultures from control animals. This study indicates that the compounds present in this sage preparation contain interesting bioactivities which improve the liver antioxidant potential.Fundação para a Ciência e a Tecnologia (FCT) - SFRH/BD/6942/2001, Programa Operacional “Ciência, Tecnologia, Inovação” (POCTI) - POCTI/AGR/43482/2001

Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage

Common sage (Salvia officinalis L., Lamiaceae) is an aromatic and medicinal plant well known for its antioxidant properties. Some in vivo studies have shown the biological antioxidant effects of sage. However, the intracellular antioxidant mechanisms of action are still poorly understood. In this study, we evaluated the cytoprotective effects of two sage extracts (a water and a methanolic extract) against tert-butyl hydroperoxide (t-BHP)-induced toxicity in HepG2 cells. The most abundant phenolic compounds present in the extracts were rosmarinic acid and luteolin-7-glucoside. Both extracts, when co-incubated with the toxicant, protected significantly HepG2 cells against cell death. The methanolic extract, with a higher content of phenolic compounds than the water extract, conferred better protection in this in vitro model of oxidative stress with liver cells. Both extracts, tested in a concentration that protects 80% against cell death (IC80), significantly prevented t-BHP-induced lipid peroxidation and GSH depletion, but not DNA damage assessed by the comet assay. The ability of sage extracts to reduce t-BHP-induced GSH depletion by 62% was probably the most relevant contributor to the observed cytoprotection. A good correlation between the above cellular effects of sage and the effects of their main phenolic compounds was found. When incubated alone for 5 h, sage extracts induced an increase in basal GSH levels of HepG2 cells, which indicates an improvement of the antioxidant potential of the cells. Compounds present in sage extracts other than phenolics may also contribute to this latter effect. Based in these results, it would be of interest to investigate whether sage has protective effects in suitable in vivo models of liver diseases, where it is known that oxidative stress is involved.Fundação para a Ciência e a Tecnologia (FCT) - SFRH/BD/6942/2001, POCI/AGR/62040/200