Privatising Public Housing Redevelopment: grassroots resistance, co-operation and devastation in three Dublin neighbourhoods

This paper examines variations in residents' responses to proposals to redevelop three public housing neighbourhoods in Dublin using Public Private Partnerships (PPPs) and the outcomes their resistance achieved. In two of these neighbourhoods community representative structures were strong and although one community co-operated with the PPP plans and the other opposed them, both were broadly successful in achieving their campaign objectives. Community structures in the third case-study area were weak however and the imposition of PPP redevelopment devastated this neighbourhood which is now almost entirely vacant. This case study is employed to critique the literature on grassroots resistance to urban redevelopment and welfare state restructuring and social housing development policy in Ireland. The paper concludes that, contrary to many researchers’ assumptions, residents' political action and resistance can significantly influence on public housing redevelopment strategies despite the dominance of neoliberal and entrepreneurial governance regimes. However, for vulnerable communities were representative structures are weak, the over-emphasis on gentrification/ social mixing and refurbishing the built environment in Irish public housing development policy can have devastating consequences. Indeed, demolition and rebuilding programmes in particular can destabilise target neighbourhoods to the extent that the residents who ultimately enjoy the benefits of public housing redevelopment are largely or entirely different from those who campaigned for its instigation

Demystifying Open Science in health psychology and behavioral medicine: a practical guide to Registered Reports and Data Notes

Open Science practices are integral to increasing transparency, reproducibility, and accessibility of research in health psychology and behavioral medicine. Drives to facilitate Open Science practices are becoming increasingly evident in journal editorial policies, including the establishment of new paper formats such as Registered Reports and Data Notes. This paper provides: (i) an overview of the current state of Open Science policies within health psychology and behavioral medicine, (ii) a call for submissions to an Article Collection of Registered Reports and Data Notes as new paper formats within the journal of Health Psychology & Behavioral Medicine, (iii) an overview of Registered Reports and Data Notes, and (iv) practical considerations for authors and reviewers of Registered Reports and Data Notes

Fine Mapping the Spatial Distribution and Concentration of Unlabeled Drugs within Tissue Micro-Compartments Using Imaging Mass Spectrometry

Readouts that define the physiological distributions of drugs in tissues are an unmet challenge and at best imprecise, but are needed in order to understand both the pharmacokinetic and pharmacodynamic properties associated with efficacy. Here we demonstrate that it is feasible to follow the in vivo transport of unlabeled drugs within specific organ and tissue compartments on a platform that applies MALDI imaging mass spectrometry to tissue sections characterized with high definition histology. We have tracked and quantified the distribution of an inhaled reference compound, tiotropium, within the lungs of dosed rats, using systematic point by point MS and MS/MS sampling at 200 µm intervals. By comparing drug ion distribution patterns in adjacent tissue sections, we observed that within 15 min following exposure, tiotropium parent MS ions (mass-to-charge; m/z 392.1) and fragmented daughter MS/MS ions (m/z 170.1 and 152.1) were dispersed in a concentration gradient (80 fmol-5 pmol) away from the central airways into the lung parenchyma and pleura. These drug levels agreed well with amounts detected in lung compartments by chemical extraction. Moreover, the simultaneous global definition of molecular ion signatures localized within 2-D tissue space provides accurate assignment of ion identities within histological landmarks, providing context to dynamic biological processes occurring at sites of drug presence. Our results highlight an important emerging technology allowing specific high resolution identification of unlabeled drugs at sites of in vivo uptake and retention

Viral coinfections in hospitalized coronavirus disease 2019 patients recruited to the international severe acute respiratory and emerging infections consortium WHO clinical characterisation protocol UK study

Background We conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity. Methods Multiplex real-time polymerase chain reaction testing for endemic respiratory viruses was performed on upper respiratory tract samples from 1002 patients with COVID-19, aged <1 year to 102 years old, recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK study. Comprehensive demographic, clinical, and outcome data were collected prospectively up to 28 days post discharge. Results A coinfecting virus was detected in 20 (2.0%) participants. Multivariable analysis revealed no significant risk factors for coinfection, although this may be due to rarity of coinfection. Likewise, ordinal logistic regression analysis did not demonstrate a significant association between coinfection and increased disease severity. Conclusions Viral coinfection was rare among hospitalized COVID-19 patients in the United Kingdom during the first 18 months of the pandemic. With unbiased prospective sampling, we found no evidence of an association between viral coinfection and disease severity. Public health interventions disrupted normal seasonal transmission of respiratory viruses; relaxation of these measures mean it will be important to monitor the prevalence and impact of respiratory viral coinfections going forward

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Privatizing Public Housing Redevelopment: grassroots resistance, co-operation and devastation in three Dublin neighbourhoods

This article examines variations in residents' responses to proposals to redevelop three public housing neighbourhoods in Dublin using Public Private Partnerships (PPPs) and the outcomes their resistance achieved. It investigates the important role that structures of participation and representation and local social cohesion play in developing effective resident resistance to displacement and gentrification through regeneration. In two of these neighbourhoods community representative structures were strong and although one community co-operated with the PPP plans and the other opposed them, both were broadly successful in achieving their campaign objectives. Community structures in the third neighbourhood were weak however and the imposition of PPP redevelopment devastated this community which is now almost entirely vacant. This article provides some important insights for the literature on grassroots resistance to urban redevelopment, welfare state restructuring and public housing redevelopment. It reveals that, despite their lack of power, residents' resistance can significantly influence public housing redevelopment strategies particularly where community representative structures are strong. However for vulnerable communities, where representative structures are weak, the over emphasis on poverty de-concentration and refurbishing the built environment in public housing redevelopment policy can have devastating consequences. Thus, it concludes that the rationale for grass roots resistance to redevelopment is centred upon a strong place attachment, but also opposition to the privatization of public housing and the desire for poverty to be addressed in an holistic manner

Demystifying Open Science in health psychology and behavioral medicine: a practical guide to Registered Reports and Data Notes

Open Science practices are integral to increasing transparency, reproducibility, and accessibility of research in health psychology and behavioral medicine. Drives to facilitate Open Science practices are becoming increasingly evident in journal editorial policies, including the establishment of new paper formats such as Registered Reports and Data Notes. This paper provides: (i) an overview of the current state of Open Science policies within health psychology and behavioral medicine, (ii) a call for submissions to an Article Collection of Registered Reports and Data Notes as new paper formats within the journal of Health Psychology & Behavioral Medicine, (iii) an overview of Registered Reports and Data Notes, and (iv) practical considerations for authors and reviewers of Registered Reports and Data Notes