2,251 research outputs found
Internal visual workmanship standard for microelectronic devices /NASA STD XX-2/ and training manual, volume 2
Internal visual workmanship standards for monolithic microelectronic devices - training manua
Three-Dimensional Quantum Percolation Studied by Level Statistics
Three-dimensional quantum percolation problems are studied by analyzing
energy level statistics of electrons on maximally connected percolating
clusters. The quantum percolation threshold \pq, which is larger than the
classical percolation threshold \pc, becomes smaller when magnetic fields are
applied, i.e., \pq(B=0)>\pq(B\ne 0)>\pc. The critical exponents are found to
be consistent with the recently obtained values of the Anderson model,
supporting the conjecture that the quantum percolation is classified onto the
same universality classes of the Anderson transition. Novel critical level
statistics at the percolation threshold is also reported.Comment: to appear in the May issue of J. Phys. Soc. Jp
Dallas with balls: televized sport, soap opera and male and female pleasures
Two of the most popular of television genres, soap opera and sports coverage have been very much differentiated along gender lines in terms of their audiences. Soap opera has been regarded very much as a 'gynocentric' genre with a large female viewing audience while the audiences for television sport have been predominantly male. Gender differentiation between the genres has had implications for the popular image of each. Soap opera has been perceived as inferior; as mere fantasy and escapism for women while television sports has been perceived as a legitimate, even edifying experience for men.
In this article the authors challenge the view that soap opera and television sport are radically different and argue that they are, in fact, very similar in a number of significant ways. They suggest that both genres invoke similar structures of feeling and sensibility in their respective audiences and that television sport is a 'male soap opera'. They consider the ways in which the viewing context of each genre is related to domestic life and leisure, the ways in which the textual structure and conventions of each genre invoke emotional identification, and finally, the ways in which both genres re-affirm gender identities
Prospective assessment of white matter integrity in adult stem cell transplant recipients
Hematopoietic stem cell transplantation (HSCT) is often used in the treatment of hematologic disorders. Although it can be curative, the pre-transplant conditioning regimen can be associated with neurotoxicity. In this prospective study, we examined white matter (WM) integrity with diffusion tensor imaging (DTI) and neuropsychological functioning before and one year after HSCT in twenty-two patients with hematologic disorders and ten healthy controls evaluated at similar intervals. Eighteen patients received conditioning treatment with high-dose (HD) chemotherapy, and four had full dose total body irradiation (fTBI) and HD chemotherapy prior to undergoing an allogeneic or autologous HSCT. The results showed a significant decrease in mean diffusivity (MD) and axial diffusivity (AD) in diffuse WM regions one year after HSCT (p-corrected <0.05) in the patient group compared to healthy controls. At baseline, patients treated with allogeneic HSCT had higher MD and AD in the left hemisphere WM than autologous HSCT patients (p-corrected <0.05). One year post-transplant, patients treated with allogeneic HSCT had lower fractional anisotropy (FA) and higher radial diffusivity (RD) in the right hemisphere and left frontal WM compared to patients treated with autologous HSCT (p-corrected <0.05). There were modest but significant correlations between MD values and cognitive test scores, and these were greatest for timed tests and in projection tracts. Patients showed a trend toward a decline in working memory, and had lower cognitive test scores than healthy controls at the one-year assessment. The findings suggest a relatively diffuse pattern of alterations in WM integrity in adult survivors of HSCT
Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus.
HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and over-expressed on the cell surface. We hypothesized that potent anti-HIV activity could be achieved if a 34 amino acid peptide from HR2 (C34) were brought to the site of virus-cell interactions by conjugation to the amino termini of HIV-1 coreceptors CCR5 or CXCR4. C34-conjugated coreceptors were expressed on the surface of T cell lines and primary CD4 T cells, retained the ability to mediate chemotaxis in response to cognate chemokines, and were highly resistant to HIV-1 utilization for entry. Notably, C34-conjugated CCR5 and CXCR4 each exhibited potent and broad inhibition of HIV-1 isolates from diverse clades irrespective of tropism (i.e., each could inhibit R5, X4 and dual-tropic isolates). This inhibition was highly specific and dependent on positioning of the peptide, as HIV-1 infection was poorly inhibited when C34 was conjugated to the amino terminus of CD4. C34-conjugated coreceptors could also inhibit HIV-1 isolates that were resistant to the soluble HR2 peptide inhibitor, enfuvirtide. When introduced into primary cells, CD4 T cells expressing C34-conjugated coreceptors exhibited physiologic responses to T cell activation while inhibiting diverse HIV-1 isolates, and cells containing C34-conjugated CXCR4 expanded during HIV-1 infection in vitro and in a humanized mouse model. Notably, the C34-conjugated peptide exerted greater HIV-1 inhibition when conjugated to CXCR4 than to CCR5. Thus, antiviral effects of HR2 peptides can be specifically directed to the site of viral entry where they provide potent and broad inhibition of HIV-1. This approach to engineer HIV-1 resistance in functional CD4 T cells may provide a novel cell-based therapeutic for controlling HIV infection in humans
Defect Formation and Critical Dynamics in the Early Universe
We study the nonequilibrium dynamics leading to the formation of topological
defects in a symmetry-breaking phase transition of a quantum scalar field with
\lambda\Phi^4 self-interaction in a spatially flat, radiation-dominated
Friedmann-Robertson-Walker Universe. The quantum field is initially in a
finite-temperature symmetry-restored state and the phase transition develops as
the Universe expands and cools. We present a first-principles, microscopic
approach in which the nonperturbative, nonequilibrium dynamics of the quantum
field is derived from the two-loop, two-particle-irreducible closed-time-path
effective action. We numerically solve the dynamical equations for the
two-point function and we identify signatures of topological defects in the
infrared portion of the momentum-space power spectrum. We find that the density
of topological defects formed after the phase transition scales as a power law
with the expansion rate of the Universe. We calculate the equilibrium critical
exponents of the correlation length and relaxation time for this model and show
that the power law exponent of the defect density, for both overdamped and
underdamped evolution, is in good agreement with the "freeze-out" scenario of
Zurek. We introduce an analytic dynamical model, valid near the critical point,
that exhibits the same power law scaling of the defect density with the quench
rate. By incorporating the realistic quench of the expanding Universe, our
approach illuminates the dynamical mechanisms important for topological defect
formation. The observed power law scaling of the defect density with the quench
rate, observered here in a quantum field theory context, provides evidence for
the "freeze-out" scenario in three spatial dimensions.Comment: 31 pages, RevTex, 8 figures in EPS forma
The Eschatological Hope Scale: Construct Development and Measurement of Theistic Eschatological Hope
This study aimed to expand psychological research on hope by contributing a construct and scale to measure central dimensions of theistic eschatological hope derived from Christian scriptures. Eschatological hope was conceptualized as the anticipation that God will make all things new, raising people to everlasting life with God in joyful celebration, including people from every culture and nation, ending all personal pain and suffering, eliminating all societal evil and harm, and bringing reconciliation and healing to all of creation. We developed the Eschatological Hope Scale with three studies (N = 1,466). Exploratory and confirmatory factor analyses supported the single-factor structure of a 6-item scale with excellent internal consistency (Cronbach\u27s α \u3e .91) and good test-retest reliability. The Eschatological Hope Scale evidenced construct validity, showing significant non-redundant correlations with measures of temporal hope, religiosity, and spirituality. The Eschatological Hope Scale scores positively correlated with gratitude, forgivingness, and life hardship patience. Scores inversely correlated with depressed and anxious symptoms, negative religious coping, and negative attitudes toward God. Scores were not significantly correlated with extrinsic religiosity and searching for meaning. The Eschatological Hope Scale demonstrated incremental validity beyond other variables (hope and optimism, depression and anxiety, and religiosity) to predict three target variables: perceived presence of meaning in life, ultimate meaning, and flourishing. We offer the Eschatological Hope Scale as a gateway scale to catalyze further developments in measuring eschatological hope. We hope this work will facilitate research on the experience of living with ultimate hope across cultures and faith traditions, in seasons of suffering and celebration
First Observation of -odd Asymmetry in Polarized Neutron Capture on Hydrogen
We report the first observation of the parity-violating 2.2 MeV gamma-ray
asymmetry in neutron-proton capture using polarized cold
neutrons incident on a liquid parahydrogen target at the Spallation Neutron
Source at Oak Ridge National Laboratory. isolates the , \mbox{} component of the weak
nucleon-nucleon interaction, which is dominated by pion exchange and can be
directly related to a single coupling constant in either the DDH meson exchange
model or pionless EFT. We measured , which implies a DDH weak coupling of
and a pionless
EFT constant of MeV. We describe the experiment, data
analysis, systematic uncertainties, and the implications of the result.Comment: 6 pages, 5 figure
Canine pseudopregnancy: an evaluation of prevalence and current treatment protocols in the UK
Background: There is a dearth of literature on pseudopregnancy in the bitch, with only a few treatment-based
studies published since the 1990s. Pseudopregnancy may be under-recognised in bitches and may account for a
proportion of behavioural cases seen in veterinary practices including aggression. Little is known about commonly
used treatments for overtly pseudopregnant bitches and it is possible that current regimes may not be prescribed
for a sufficient duration to control any clinical signs including, physical and behavioural changes. To investigate
current trends in diagnosis and treatment of canine pseudopregnancy, a postal survey was sent to 2000 randomly
selected veterinary surgeons in UK veterinary practices. The questionnaire queried how often vets recognise cases
of pseudopregnancy in spayed and entire bitches, which physical or behavioural signs are commonly recognised
for diagnosis, and which management or treatment protocols are used.
Results: The response rate was 19.8% (397/2000). Ninety-six percent of veterinary surgeons reported seeing
pseudopregnant bitches showing behavioural changes without any physical changes within the last 12 months.
Of those behavioural changes, collecting and mothering objects was the most frequently reported behavioural
sign (96%). Ninety-seven percent of vets had seen aggression in pseudopregnant bitches. Nevertheless, only 52%
of vets routinely asked owners about behavioural changes during consultations. Forty-nine percent of respondents
reported seeing pseudopregnancy in spayed bitches. The most commonly reported physical sign was enlarged
mammary glands and/or milk production (89%). Treatment options varied (surgical, medical or none) and depended on
duration and severity of physical and behavioural signs, owners’ preference, cost, concurrent disease, drug availability
and previous history.
Conclusions: This is the largest epidemiological study of canine pseudopregnancy in the UK. The prevalence and
severity of clinical signs in dogs with pseudopregnancy are variable and possibly under-estimated. Dogs with overt
pseudopregnancy experience diverse physical and behavioural changes and information on standard treatment
protocols are lacking. Although, progress on our understanding of diagnosis and treatment of pseudopregnancy in
spayed and entire bitches has been made, further studies are warranted
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