Why not default? An interview with Jerome Roos

Jerome Roos is an LSE Fellow in International Political Economy (IPE) at the Department of International Development of the London School of Economics. His research focuses on the political economy of global finance, sovereign debt and international crisis management. He holds a dual degree in International Political Economy from Sciences Po Paris and the London School of Economics, and a PhD in Political and Social Sciences from the European University Institute in Florence. Jerome’s first book,Why Not Default? has won the first Immanuel Wallerstein Memorial Book Award from the American Sociological Association. The book,published by Princeton University Press in 2019, seeks tounravel a striking puzzle at the heart of the global debt regime: why, despite frequent crises and the immense costs of repayment, do so many heavily indebted countries continue to service their international debts

The mtDNA diversity of captive ruffed lemurs (Varecia spp.): Implications for conservation

Ruffed lemurs (Varecia variegata and V. rubra) are considered Critically Endangered, and genetic studies are therefore needed for assessing the conservation value of captive populations. Using 280 mitochondrial DNA (mtDNA) D-loop sequences, we studied the genetic diversity and structure of captive ruffed lemurs in Madagascar, Europe and North America. We found 10 new haplotypes, one from the European captive V. rubra population, three from captive V. variegata subcincta (one from Europe and two from Madagascar), and six from other captive V. variegata in Madagascar. There was low mtDNA genetic diversity in the European and North American captive populations of V. variegata. Several founder individuals shared the same mtDNA haplotype, and therefore should perhaps not be considered as unrelated founders for making breeding recommendations. The captive population in Madagascar has high genetic diversity, including haplotypes not yet identified in wild populations. The likely geographical provenance of founders of captive populations was determined by comparison with previous studies; all reported haplotypes from captive ruffed lemurs were identical to, or clustered with, haplotypes from wild populations located north of the Mangoro River in Madagascar. Effective conservation strategies for wild populations, with potentially unidentified genetic diversity, should still be considered the priority for conserving ruffed lemurs. However, our results illustrate that the captive population in Madagascar has conservation value as a source of potential release stock for reintroduction or reinforcement projects, and that cross-regional transfers within the global captive population could increase the genetic diversity and therefore the conservation value of each regional population

Quantitative cardiovascular magnetic resonance in pregnant women: cross-sectional analysis of physiological parameters throughout pregnancy and the impact of the supine position

There are physiological reasons for the effects of positioning on hemodynamic variables and cardiac dimensions related to altered intra-abdominal and intra-thoracic pressures. This problem is especially evident in pregnant women due to the additional aorto-caval compression by the enlarged uterus. The purpose of this study was to investigate the effect of postural changes

Diuretics in pregnancy:Data from the ESC Registry of Pregnancy and Cardiac disease (ROPAC)

Aims: Data on diuretic use in pregnancy are limited and inconsistent, and consequently it remains unclear whether they can be used safely. Our study aims to evaluate the perinatal outcomes after in-utero diuretic exposure. Methods and results: The Registry Of Pregnancy And Cardiac disease (ROPAC) is a prospective, global registry of pregnancies in women with heart disease. Outcomes were compared between women who used diuretics during pregnancy versus those who did not. Multivariable regression analysis was used to assess the impact of diuretic use on the occurrence of congenital anomalies and foetal growth. Diuretics were used in 382 (6.7%) of the 5739 ROPAC pregnancies, most often furosemide (86%). Age &gt;35 years (odds ratio [OR] 1.5, 95% confidence interval [CI] 1.2–2.0), other cardiac medication use (OR 5.4, 95% CI 4.2–6.9), signs of heart failure (OR 1.7, 95% CI 1.2–2.2), estimated left ventricular ejection fraction &lt;40% (OR 2.9, 95% CI 2.0–4.2), New York Heart Association class &gt;II (OR 3.4, 95% CI 2.3–5.1), valvular heart disease (OR 6.3, 95% CI 4.7–8.3) and cardiomyopathy (OR 3.9, 95% CI 2.6–5.7) were associated with diuretic use during pregnancy. In multivariable analysis, diuretic use during the first trimester was not significantly associated with foetal or neonatal congenital anomalies (OR 1.3, 95% CI 0.7–2.6), and diuretic use during pregnancy was also not significantly associated with small for gestational age (OR 1.4, 95% CI 1.0–1.9). Conclusions: Our study does not conclusively establish an association between diuretic use during pregnancy and adverse foetal outcomes. Given these findings, it is essential to assess the risk–benefit ratio on an individual basis to guide clinical decisions.</p

Overseeing the overseers: assessing compliance with municipal intervention rules in South Africa

Section 139 of the Constitution of South Africa empowers provinces to intervene into municipalities, an instrument to correct serious failures in local government. This article discusses the policy and legal framework for interventions and assesses whether the constitutional provisions that circumscribe it, are being adhered to. The starting point is that decentralisation, of which this instrument is part, is rules-based and that adherence to the rule of law is critical for its success. By its very nature, intervention represents an intrusion into the institutional integrity of the affected municipality and adherence to the constitutional safeguards surrounding the intervention is therefore critical. The article sets out the constitutional framework for interventions into municipalities which includes oversight roles for the Minister responsible for local government, the National Council of Provinces and the provincial legislature. It combines this with an assessment of 39 interventions that took place between 2008 and 2014. It presents a provincial breakdown and a breakdown of the legal basis of these 39 interventions. It concludes that provinces don’t use the interventions envisaged in Section 139(4) and (5) but instead almost always intervene in terms of Section 139(1) of the Constitution. The interventions are assessed for compliance with constitutional prescripts, such as the need to establish a failure to fulfil an executive obligation, the timely submission of the intervention to the Minister and the NCOP and their timely approval. The article concludes that a significant number of interventions did not comply with the pro- visions pertaining to the timely submission and approval by the Minister and the NCOP. Furthermore, there is a need to accelerate the adoption of the legislation envisaged by Section 139(8) of the Constitution to further regulate interventions

Assessment of perinatal outcome after sustained tocolysis in early labour (APOSTEL-II trial)

Contains fulltext : 80242.pdf (publisher's version ) (Open Access)BACKGROUND: Preterm labour is the main cause of perinatal morbidity and mortality in the Western world. At present, there is evidence that tocolysis for 48 hours is useful in women with threatened preterm labour at least before 32 weeks. This allows transfer of the patient to a perinatal centre, and maximizes the effect of corticosteroids for improved neonatal survival. It is questionable whether treatment with tocolytics should be maintained after 48 hours. METHODS/DESIGN: The APOSTEL II trial is a multicentre placebo-controlled study. Pregnant women admitted for threatened preterm labour who have been treated with 48 hours corticosteroids and tocolysis will be eligible to participate in the trial between 26+0 and 32+2 weeks gestational age. They will be randomly allocated to nifedipine (intervention) or placebo (control) for twelve days or until delivery, whatever comes first.Primary outcome is a composite of perinatal death, and severe neonatal morbidity up to evaluation at 6 months after birth. Secondary outcomes are gestational age at delivery, number of days in neonatal intensive care and total days of the first 6 months out of hospital. In addition a cost-effectiveness analysis will be performed. Analysis will be by intention to treat. The power calculation is based on an expected 11% difference in adverse neonatal outcome. This implies that 406 women have to be randomised (two sided test, beta 0.2 at alpha 0.05). DISCUSSION: This trial will provide evidence as to whether maintenance tocolysis reduces severe perinatal morbidity and mortality in women with threatened preterm labour before 32 weeks. TRIAL REGISTRATION: Clinical trial registration: http://www.trialregister.nl, NTR 1336, date of registration: June 3rd 2008