3,959 research outputs found

    Chromosome analysis by non-isotopic in situ hybridization.

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    Application of NASAP to the design of communication circuits

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    Modifications to CDC 3600 NASAP for design of linear communication circuit

    William E. Rooney to Dr. Silver, 2 September 1958

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    Professional correspondenc

    The Effect of Playback Theatre on Managing Elderly Bullying in Senior Communities

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    This qualitative research project explores the long established social problem of bullying among the expanding population of adults over 65. One of the main goals is to identify effective interventions in addressing the problem, specifically Playback Theatre. Grounded theory was implemented in data analysis. The social work theory of Person in Environment (PIE) and Systems Theory were used as the theoretical framework for formulating questions and interpreting answers. Seven professionals working in assisted living and senior public housing were questioned regarding their observations and experiences of elderly bullying within their facilities. Data analysis occurred within a three-month period. The main theme that emerged is the lack of evidence-based interventions. Other prominent themes include: (a) what bullying looks like in the studied population, (b) where bullying most often occurs, (c) reasons for bullying among older adults, (d) what interventions are currently being used, (e) Playback Theatre, (f) use and attitudes towards art-based interventions, (g) what type of training professionals have in dealing with bullying, and (h) messages communities can use to address bullying

    A study of the Rhode Island schools' science fair and its winners, 1946 through 1949

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    Thesis (Ed.M.)--Boston Universit

    Links Between Social Support, Thwarted Belongingness, and Suicide Ideation among Lesbian, Gay, and Bisexual College Students

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    Emerging adults with a lesbian, gay, or bisexual (LGB) identity are at greater risk for engaging in suicide-related behaviors. This disparity highlights a need to elucidate specific risk and protective factors associated with suicide-related behaviors among LGB youth, which could be utilized as targets for suicide prevention efforts in this population. Informed by the interpersonal-psychological theory of suicide, the present study hypothesized that social support would be indirectly associated with decreased suicide ideation via lower thwarted belongingness. A sample of 50 emerging adults (62.0% male, 70.0% Hispanic) who identified as gay, lesbian, bisexual, questioning, or “other” orientation, with a mean age of 20.84 years (SD = 3.30 years), completed self-report assessments. Results indicated that support from both family and the LGB community were associated with lower thwarted belongingness over and above the effects of age, sex, and depressive symptoms. Indirect effects models also indicated that both family and LGB community support were associated with suicide ideation via thwarted belongingness. The results of the present study suggest that family and LGB community support may represent specific targets for reducing thwarted belongingness that could be leveraged in suicide prevention efforts for LGB emerging adults

    lHuman cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis

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    Effector-memory T cells expressing Fas (Apo-1/CD95) are switched to an apoptotic program by cross-linking with Fas-ligand (FasL). Consequently, tumors that express FasL can induce apoptosis of infiltrating Fas-positive T lymphocytes and subdue any antitumor host immune response. Since Epstein-Barr virus (EBV)-associated tumors such as Hodgkin lymphoma (HL) and nasopharyngeal carcinoma (NPC) express FasL, we determined whether EBV-specific cytotoxic T lymphocytes (EBV-CTLs) could be modified to resist this evasion strategy. We show that long-term down-modulation of Fas can be achieved in EBV-CTLs by transduction with small interfering RNA (siRNA) encoded in a retrovirus. Modified T cells resisted Fas/FasL-mediated apoptosis compared with control cells and showed minimal cleavage of the caspase3 substrate poly(ADP-ribose) polymerase (PARP) protein after Fas engagement. Prolonged Fas stimulation selected a uniformly Fas(low) and FasL resistant population. Removal of responsiveness to this single death signal had no other discernible effects on EBV-CTLs. In particular, it did not lead to their autonomous growth since the modified EBV-CTLs remained polyclonal, and their survival and proliferation retained dependence on antigen-specific stimulation and on the presence of other physiologic growth signals. EBV-CTLs with knocked down Fas should have a selective functional and survival advantage over unmodified EBV-CTLs in the presence of tumors expressing FasL and may be of value for adoptive cellular therapy. (c) 2005 by The American Society of Hematology

    Magmatic Rifting and Active Volcanism Conference, Afar Rift Consortium

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    The Magmatic Rifting and Active Volcanism (MRAV) Conference took place in Addis Ababa, Ethiopia January 10-13, 2012, convened by members of the Afar Rift Consortium, an international team investigating active magmatism and deformation in the Afar region. Over 200 people from around the world attended. The conference participants primarily presented the results of work on ongoing rifting processes in Afar, but work was also presented that addressed other portions of the East African Rift, comparable rift settings elsewhere, rifting processes in general, and the hazards and resources associated with the East African Rift. The scientific program outlined the current state of knowledge in the East African rift and placed recent discoveries within the broader context of rift-related research globally. Central to the meeting was the presentation of results from thematic, multi-collaborator, international programs (e.g. Afar Consortium, RiftLink, Actions Marges), individual research groups, and industrial partners. The rich detail and modern datasets presented at the meeting highlight the importance of the existing infrastructure of international research in East Africa, which should be leveraged by GeoPRISMS to effectively focus resources in the extensive East African Rift System primary site

    Spherical Harmonics for the 1D Radiative Transfer Equation I: Reflected Light

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    A significant challenge in radiative transfer theory for atmospheres of exoplanets and brown dwarfs is the derivation of computationally efficient methods that have adequate fidelity to more precise, numerically demanding solutions. In this work, we extend the capability of the first open-source radiative transfer model for computing the reflected light of exoplanets at any phase geometry, PICASO: Planetary Intensity Code for Atmospheric Spectroscopy Observations. Until now, PICASO has implemented two-stream approaches to the solving the radiative transfer equation for reflected light, in particular following the derivations of Toon et al. (1989) (Toon89). In order to improve the model accuracy, we have considered higher-order approximations of the phase functions, namely, we have increased the order of approximation from 2 to 4, using spherical harmonics. The spherical harmonics approximation decouples spatial and directional dependencies by expanding the intensity and phase function into a series of spherical harmonics, or Legendre polynomials, allowing for analytical solutions for low-order approximations to optimize computational efficiency. We rigorously derive the spherical harmonics method for reflected light and benchmark the 4-term method (SH4) against Toon89 and two independent and higher-fidelity methods (CDISORT & doubling-method). On average, the SH4 method provides an order of magnitude increase in accuracy, compared to Toon89. Lastly, we implement SH4 within PICASO and observe only modest increase in computational time, compared to two-stream methods (20% increase).Comment: Accepted ApJ; 27 pages; 5 figures; Code available at https://github.com/natashabatalha/picaso; Zenodo release at https://zenodo.org/record/7765171#.ZC3G7uzMI8Y; Tutorials/figure reproducibility at https://natashabatalha.github.io/picaso/notebooks/10b_AnalyzingApproximationsReflectedLightSH.htm

    Spherical Harmonics for the 1D Radiative Transfer Equation II: Thermal Emission

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    Approximate methods to estimate solutions to the radiative transfer equation are essential for the understanding of atmospheres of exoplanets and brown dwarfs. The simplest and most popular choice is the "two-stream method" which is often used to produce simple yet effective models for radiative transfer in scattering and absorbing media. Toon et al. (1989) (Toon89) outlined a two-stream method for computing reflected light and thermal spectra and was later implemented in the open-source radiative transfer model PICASO. In Part~I of this series, we developed an analytical spherical harmonics method for solving the radiative transfer equation for reflected solar radiation (Rooney et al. 2023), which was implemented in PICASO to increase the accuracy of the code by offering a higher-order approximation. This work is an extension of this spherical harmonics derivation to study thermal emission spectroscopy. We highlight the model differences in the approach for thermal emission and benchmark the 4-term method (SH4) against Toon89 and a high-stream discrete-ordinates method, CDISORT. By comparing the spectra produced by each model we demonstrate that the SH4 method provides a significant increase in accuracy, compared to Toon89, which can be attributed to the increased order of approximation and to the choice of phase function. We also explore the trade-off between computational time and model accuracy. We find that our 4-term method is twice as slow as our 2-term method, but is up to five times more accurate, when compared with CDISORT. Therefore, SH4 provides excellent improvement in model accuracy with minimal sacrifice in numerical expense.Comment: Submitted ApJ; 17 pages; 7 figures; Code available at https://github.com/natashabatalha/picaso; Zenodo release at https://zenodo.org/record/7765171#.ZC3G7uzMI8Y; Tutorials/figure reproducibility at https://natashabatalha.github.io/picaso/notebooks/10c_AnalyzingApproximationsThermal.html
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