Investigation of MIMO Channel Characteristics in a Two-Section Tunnel at 1.4725 GHz

This paper presents results from a wide band single-input–single-output (SISO) and 16 × 16 virtual multiple-input–multiple-output (MIMO) measurement campaign at a center frequency of 1.4725 GHz in a 100-meter long tunnel laboratory which is terminated by a vertical wall with a metallic door. The path loss, root-mean-square delay spread (RMS-DS) characteristics, and power delay profiles (PDPs) are described. In addition, we provide results for the MIMO channel amplitude matrix, which offers a new perspective in understanding MIMO characteristics in tunnel scenarios. Our measurement results are analyzed and compared to ray tracing simulations. The relationships among the angle spread, channel matrix singular values, and MIMO capacity at various link distances are illustrated, and these provide insights into MIMO system deployment

Computationally efficient angle estimation of bistatic MIMO radar based on multimodal optimization

Abstract In this letter, a computationally efficient multiple signal classification (MUSIC)‐based evolutionary algorithm for angle estimation of bistatic multiple‐input multiple‐output (MIMO) radar is proposed. The existing MUSIC algorithms require a computationally cumbersome two‐dimensional (2D) peak searching and the performance is highly related to the grid that set, which leads to a conflict between the computational efficiency and estimation performance. To address this difficulty, a multimodal quantum‐inspired salp swarm algorithm, integrating kmeans clustering technique, is proposed to substitute the 2D peak searching to obtain multiple maxima of the MUSIC algorithm. The resulting computationally efficient algorithm obviously reduces the computational complexity of the MUSIC algorithm, avoids grid errors, and further exploits the potential of the MUSIC algorithm. Numerical simulations in various scenarios are carried out to verify the superiority of the method

Optimization of AICD water control completion technology for horizontal well in bottom water gas reservoir

At present, adaptive inflow control (AICD) water-controlled completion technology is mainly applied to reservoir water control. In view of the gas reservoir AICD water control completion technology research is still blank, this paper carried out a suitable for gas reservoir water control water control mechanism of the new type runner AICD and flow characteristics analysis, X oilfield bottom water reservoir is established new port type AICD water control completion. The structure parameter combination of the new AICD was analyzed and optimized by orthogonal test, and the water control effect of the new AICD water control completion was analyzed. The results show that compared with conventional perforation completions, the new AICD controlled water completions cause little bottom hole pressure loss and have little effect on condensate production. New type runner AICD completion can prolong the bottom water reservoir water control in low yielding water gas recovery period of about 365 days, predict 20 years of accumulated water rate reduced about 27%, water saturation near wellbore area is generally lower, has good effect of water control. The new flow channel type AICD controlled water completion can be applied to the development of bottom water gas reservoirs to control water and stabilize gas

Neoadjuvant chemotherapy reduces the levels of HMGB1 and E-cadherin in patients with breast cancer

Abstract This study investigated the changes in serum tumor marker levels in patients with breast cancer (BC) after neoadjuvant chemotherapy (NACT) and their potential as prognostic factors in NACT. A total of 134 consecutive patients with BC treated at our hospital between January 2019 and December 2021 were retrospectively analyzed. Patients were treated with NACT based on the docetaxel, epirubicin, and cyclophosphamide (TEC) regimen and assessed for marker levels, T cell subsets, and therapeutic outcomes. Receiver operating characteristic (ROC) curves were constructed to evaluate the predictive performance of the markers. Outcome assessments showed that NACT effectively reduced the tumor size, leading to increased complete remission, partial remission, stable disease, and significantly reduced disease progression. Improved immune function has also been observed after NACT. The levels of two (E-cadherin and HMGB1) out of five markers (CA153, CK19, CEA, E-cadherin, and HMGB1) were significantly reduced after NACT before surgery compared with those at admission, suggesting that NACT modulates the levels of biomarkers. ROC analysis revealed that the area under the curve (AUC) of HMGB1 and E-cadherin combination was 0.87 for discrimination of therapeutic response with a sensitivity and specificity of 91.3% and 88.4%, respectively. Serum tumor marker levels were reduced after NACT in patients with BC. The reduction was most prominent for HMGB1, followed by E-cadherin. These biomarkers can be used to predict the therapeutic response to NACT with an AUC of 0.87, thus offering a new tool to monitor treatment progress in NACT for patients with BC

Insights into Manganese Superoxide Dismutase and Human Diseases

Redox equilibria and the modulation of redox signalling play crucial roles in physiological processes. Overproduction of reactive oxygen species (ROS) disrupts the body’s antioxidant defence, compromising redox homeostasis and increasing oxidative stress, leading to the development of several diseases. Manganese superoxide dismutase (MnSOD) is a principal antioxidant enzyme that protects cells from oxidative damage by converting superoxide anion radicals to hydrogen peroxide and oxygen in mitochondria. Systematic studies have demonstrated that MnSOD plays an indispensable role in multiple diseases. This review focuses on preclinical evidence that describes the mechanisms of MnSOD in diseases accompanied with an imbalanced redox status, including fibrotic diseases, inflammation, diabetes, vascular diseases, neurodegenerative diseases, and cancer. The potential therapeutic effects of MnSOD activators and MnSOD mimetics are also discussed. Targeting this specific superoxide anion radical scavenger may be a clinically beneficial strategy, and understanding the therapeutic role of MnSOD may provide a positive insight into preventing and treating related diseases

Repurposing of Anthocyanin Biosynthesis for Plant Transformation and Genome Editing.

CRISPR/Cas9 gene editing technology has been very effective in editing genes in many plant species including rice. Here we further improve the current CRISPR/Cas9 gene editing technology in both efficiency and time needed for isolation of transgene-free and target gene-edited plants. We coupled the CRISPR/Cas9 cassette with a unit that activates anthocyanin biosynthesis, providing a visible marker for detecting the presence of transgenes. The anthocyanin-marker assisted CRISPR (AAC) technology enables us to identify transgenic events even at calli stage, to select transformants with elevated Cas9 expression, and to identify transgene-free plants in the field. We used the AAC technology to edit LAZY1 and G1 and successfully generated many transgene-free and target gene-edited plants at T1 generation. The AAC technology greatly reduced the labor, time, and costs needed for editing target genes in rice

Integrated physiological, metabolomic, and transcriptomic analyses elucidate the regulation mechanisms of lignin synthesis under osmotic stress in alfalfa leaf (Medicago sativa L.)

Abstract Alfalfa, an essential forage crop known for its high yield, nutritional value, and strong adaptability, has been widely cultivated worldwide. The yield and quality of alfalfa are frequently jeopardized due to environmental degradation. Lignin, a constituent of the cell wall, enhances plant resistance to abiotic stress, which often causes osmotic stress in plant cells. However, how lignin responds to osmotic stress in leaves remains unclear. This study explored the effects of osmotic stress on lignin accumulation and the contents of intermediate metabolites involved in lignin synthesis in alfalfa leaves. Osmotic stress caused an increase in lignin accumulation and the alteration of core enzyme activities and gene expression in the phenylpropanoid pathway. We identified five hub genes (CSE, CCR, CADa, CADb, and POD) and thirty edge genes (including WRKYs, MYBs, and UBPs) by integrating transcriptome and metabolome analyses. In addition, ABA and ethylene signaling induced by osmotic stress regulated lignin biosynthesis in a contradictory way. These findings contribute to a new theoretical foundation for the breeding of high-quality and resistant alfalfa varieties