Investigation on the Hydrogeochemical Characteristics and Controlling Mechanisms of Groundwater in the Coastal Aquifer

Groundwater contamination in coastal areas has attracted widespread attention. However, studies on the hydrogeochemical characteristics and controlling mechanisms in coastal aquifers are still lacking. In this study, 71 sets of groundwater samples were collected during the dry and wet seasons in a coastal city, Shandong Province. Correlation and principal component analyses were used to identify pollution sources. Meanwhile, Piper diagrams, Gibbs plots, ion ratios, and saturation indices were employed to investigate the hydrogeochemical controlling mechanisms. The results revealed that pollution components included Na+, NH4+, Cl−, SO42−, NO3−, NO2−, Pb, As, Se, TDS, TH, F−, and Mn. Pollution compositions in the study area were primarily derived from natural processes and anthropogenic activities. The contamination of nitrogen resulted primarily from agricultural activities. The exceedance of SO42− was mainly due to the leaching of waste by rainfall. High Na+, Cl−, and F− were related to sea intrusion. Pb and Se might have been caused by anthropogenic activities. The exceedance of As was caused by anthropogenic inputs and natural factors. The poor seepage conditions and anoxic conditions promoted the enrichment of Mn. The concentration of most components in the dry season was larger than that in the wet season. There were no significant differences in water chemistry type during the wet season and dry season. Groundwater chemical compositions were dominated by the dissolution of halite, gypsum, and anhydrite, as well as the cation exchange reaction. The influence of seawater intrusion on groundwater was not serious

Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo

Renifolin F is a prenylated chalcone isolated from Shuteria involucrata, a traditional minority ethnic medicine used to treat the respiratory diseases and asthma. Based on the effects of the original medicine plant, we established an in vivo mouse model of allergic asthma using ovalbumin (OVA) as an inducer to evaluate the therapeutic effects of Renifolin F. In the research, mice were sensitized and challenged with OVA to establish an allergic asthma model to evaluate the effects of Renifolin F on allergic asthma. The airway hyper-reactivity (AHR) to methacholine, cytokine levels, ILC2s quantity and mircoRNA-155 expression were assessed. We discovered that Renifolin F attenuated AHR and airway inflammation in the OVA-induced asthmatic mouse model by inhibiting the regulation of ILC2s in the lung, thereby, reducing the upstream inflammatory cytokines IL-25, IL-33 and TSLP; the downstream inflammatory cytokines IL-4, IL-5, IL-9 and IL-13 of ILC2s; and the co-stimulatory factors IL-2 and IL-7; as well as the expression of microRNA-155 in the lung. The findings suggest a therapeutic potential of Renifolin F on OVA-induced airway inflammation

The First Ka-band (26.1–35 GHz) Blind Line Survey toward Orion KL

We conducted a Ka -band (26.1–35 GHz) line survey toward Orion KL using the TianMa 65 m Radio Telescope (TMRT). It is the first blind line survey in the Ka band and achieves a sensitivity at the mK level (1–3 mK at a spectral resolution of ∼1 km s ^−1 ). In total, 592 Gaussian features are extracted. Among them, 257 radio recombination lines (RRLs) are identified. The maximum Δ n of RRLs of H, He, and C are 20, 15, and 5, respectively. Through stacking, we have detected the β lines of ion RRLs (RRLs of C ^+ with the possible contribution of other ions like O ^+ ) for the first time, and a tentative signal of the γ lines of ion RRLs can also be seen on the stacked spectrum. Besides this, 318 other line features were assigned to 37 molecular species, and 10 of these species were not detected in the Q -band survey of TMRT. The vibrationally excited states of nine species were also detected. The emission of most species can be modeled under LTE. A number of transitions of E-CH3OH ( J _2 − J _1 ) display maser effects, which are confirmed by our modeling, and besides the bumping peak at J ∼ 6, there is another peak at J ∼ 13. Methylcyanoacetylene (CH _3 C _3 N) is detected in Orion KL for the first time. This work emphasizes that the Ka band, which was long ignored for spectral line surveys, is very useful for surveying RRLs and molecular lines simultaneously