Modelo de educación de la inteligencia colectiva

The research carried out is part of the field of study of Collective Intelligence (CI) with the use of Information and Communication Technologies (ICT) in Higher Education. The heart of this research was focused on the study, design and construction of electronic tools according to the paradigms of CI, to be applied in Higher Education. As an instrument for the implementation of these tools, an educational model with a collective work approach was designed. The research strategy used was Design-Based Research (DBR), because it investigates a phenomenon in its real context, iterative and incremental, and it is especially recommended for the field of education. DBR in each experimental cycle updates literature, model and tools. Empirical studies were conducted in four universities and fields of study in Latin America and Europe. The refinements demanded by the research strategy provided the scientific and empirical evidence to design ICT tools that meet the requirements of CI. In addition, the results indicate that the educational model and the tools have generated a positive perception in teachers and students about the effects on the teaching-learning process. Based on this fact, the experimental cycles present significant contributions to the research carried out around the CI with ICT tools in Higher Education.La investigación realizada se enmarca en el campo de estudio de la Inteligencia Colectiva (IC) con el uso de las Tecnologías de la Información y la Comunicaciones (TIC) en la Educación Superior. El corazón de ésta investigación estuvo enfocada en el estudio, diseño y construcción de herramientas electrónicas acorde a los paradigmas de IC, para ser aplicadas en la Educación Superior. Como vía de instrumentación de dichas herramientas, se diseñó un modelo educativo con enfoque de trabajo colectivo. La estrategia de investigación que se utilizó fue la Investigación Basada en el Diseño (DBR), porque investiga un fenómeno en su contexto real, es iterativa e incremental, y está especialmente recomendada para el ámbito de la educación.DBR en cada ciclo experimental actualiza literatura, modelo y herramientas. Los estudios empíricos se realizaron en cuatro universidades y campos de estudio en Hispanoamérica y Europa. Los múltiples refinamientos exigidos por la estrategia de investigación, proporcionaron la evidencia científica y empírica para diseñar herramientas TIC que cumplan con los requisitos de IC. Además, los resultados indican que el modelo educativo y las herramientas han generado una percepción positiva en docentes y estudiantes sobre los efectos en el proceso de enseñanza-aprendizaje. Basados en este hecho, los ciclos experimentales presentan aportes significativos a las investigaciones que se realizan en torno a la IC con herramientas TIC en la Educación Superior

MOESM2 of Aikeqing decreases viral loads in SHIV89.6-infected Chinese rhesus macaques

Additional file 2. The ARRIVE guidelines checklist

Schilancitrilactones A–C: Three Unique Nortriterpenoids from Schisandra lancifolia

Three unique nortriterpenoids, schilancitrilactones A–C (<b>1</b>–<b>3</b>), were isolated from the stems of Schisandra lancifolia. Compound <b>1</b> possesses a 5/5/7/5/5/5-fused hexacyclic ring system with a C₂₉ backbone, while <b>2</b> and <b>3</b> feature a C₂₇ skeleton with a 5/7/5/5/5-fused pentacyclic ring system. Their absolute stereochemistries were established by CD and single-crystal X-ray diffraction experiments. Compound <b>3</b> showed anti-HIV-1 activity with an EC₅₀ value of 27.54 μg/mL, and <b>1</b> exhibited antifeedant activity at 15.73 μg/cm²

Schilancitrilactones A–C: Three Unique Nortriterpenoids from Schisandra lancifolia

Three unique nortriterpenoids, schilancitrilactones A–C (<b>1</b>–<b>3</b>), were isolated from the stems of Schisandra lancifolia. Compound <b>1</b> possesses a 5/5/7/5/5/5-fused hexacyclic ring system with a C₂₉ backbone, while <b>2</b> and <b>3</b> feature a C₂₇ skeleton with a 5/7/5/5/5-fused pentacyclic ring system. Their absolute stereochemistries were established by CD and single-crystal X-ray diffraction experiments. Compound <b>3</b> showed anti-HIV-1 activity with an EC₅₀ value of 27.54 μg/mL, and <b>1</b> exhibited antifeedant activity at 15.73 μg/cm²

Cytotoxicity of DB-02 in C8166, MT-4 and PBMC using MTT methods.

<p>DB-02 showed low cytotoxicity to all the three types of aforementioned cells above. CC₅₀ of these cells were all >1000μM, respectively.</p

RT activity of DB-2 <i>in</i><i>vitro</i>.

<p>The RT activity was measured by ELISA using DIG-labeled dNTPs, which were incorporated into the newly synthesized cDNA. The figure represents three independent experiments.</p

Structures of <i>S</i>-DABO and DB-02.

<p>Structures of <i>S</i>-DABO and DB-02.</p

Genotypic patterns of HIV-1_IIIB selected by FNC and 3TC.

<p>Genotypic patterns of HIV-1_IIIB selected by FNC and 3TC.</p

Mechanisim of action of FNC.

<p>Quantification of HIV-1 DNA species. ssDNA (<b>A</b>) and late-RT (<b>B</b>). All experiments were conducted in the presence or absence of 2nM FNC and 2 µM 3TC. Each group was tested in triplicates and data are presented as mean ± standard deviations (SD).</p

Chemical structures of FNC and 3TC.

<p>Chemical structures of FNC and 3TC.</p