Effect of Acidic Properties of Mesoporous Zeolites Supporting Pt Nanoparticles on Hydrogenative Conversion of Methylcyclopentane

The effect of acidic properties of mesoporous zeolites on the control of product selectivity during the hydrogenative isomerization of methylcyclopentane has been investigated. A series of mesoporous zeolites with controlled acidic properties were prepared by postdealumination process with hydrochloric acid under hydrothermal conditions, and the resultant zeolites used for supporting colloidal Pt nanoparticles (NPs) with a mean size of 2.5 nm (±0.6 nm). As compared to the pure Pt NPs supported on catalytically inert mesoporous silica (MCF-17) as the reference catalyst that can produce isomers most selectively (∼80%), the Pt NPs supported on mesoporous zeolites produced C₆-cyclic hydrocarbons (i.e., cyclohexane and benzene) most dominantly. The type and strength of the Brönsted (B) and Lewis (L) acid sites of those zeolites with a controlled Al amount are analyzed by using FT-IR after the adsorption of pyridine and NH₃ temperature-programmed desorption measurements, and they are correlated with the selectivity change between cyclohexane and benzene. From this investigation, we found a linear relationship between the number of Brönsted acid sites and the formation rate for cyclohexane. In addition, we revealed that more Lewis acidic zeolite having relatively smaller B/L ratio is effective for the cyclohexane formation, whereas more Brönsted acidic zeolite having relatively larger B/L ratio is effective for the benzene formation

Dendrimer-Stabilized Metal Nanoparticles as Efficient Catalysts for Reversible Dehydrogenation/Hydrogenation of N‑Heterocycles

Nanoparticles (Pd, Pt, Rh) stabilized by G4OH PAMAM dendrimers and supported in SBA-15 (<b>MNPs/SBA-15</b> with M = Pd, Pt, Rh) were efficiently used as catalysts in the acceptorless dehydrogenation of tetrahydroquinoline/indoline derivatives in toluene (release of H₂) at 130 °C. These catalysts are air stable, very active, robust, and recyclable during the process. The reverse hydrogenation reaction of quinoline derivatives (H₂ storage) was also optimized and successfully performed in the presence of the same catalysts in toluene at 60 °C under only 1 atm of hydrogen gas. Such catalysts may be essential for the adoption of organic hydrogen-storage materials as an alternative to petroleum-derived fuels. Hot filtration test confirmed that the reaction follows a heterogeneous pathway. Moreover, <b>PdNPs/SBA-15</b> was an excellent catalyst for the direct arylation at the C-2 position (via C–H activation) of indole in water in the presense of a hypervalent iodine oxidant. Thus, a one-pot dehydrogenation/direct arylation cascade reaction between indoline and an arylated agent was efficaciously performed in water, demonstrating the potential of the system to catalyze tandem heterogeneous/homogeneous processes by choice of the appropriate oxidant/reductant

The Relationship between Parkinson Disease and Brain Tumor: A Meta-Analysis

<div><p>Objective</p><p>Epidemiological studies have investigated the association between Parkinson disease (PD) occurrence and the risk of brain tumors, while the results remain controversial. We performed a meta-analysis to clarify the exact relationship between PD and brain tumors.</p><p>Methods</p><p>A systematic literature search was conducted using PubMed, Embase, ScienceDirect and CBM (China Biology Medicine Disc) before February 2016. Eligible studies were those that reported risk estimates of brain tumors among patients with PD or vice versa. A random-effects model was used to calculate the pooled odds ratio (OR) of the outcomes. Subgroup analyses and sensitivity analysis were conducted to explore the potential sources of heterogeneity.</p><p>Results</p><p>In total, eight studies involving 329,276 participants met our inclusion criteria. The pooled OR was 1.51 (95%CI 1.21–1.89), indicating that PD carried a higher risk of brain tumor. Analyses by temporal relationship found that the occurrence of brain tumor was significantly higher after the diagnosis of PD (OR 1.55, 95% CI 1.18–2.05), but not statistically significant before PD diagnosis (OR 1.21, 95%CI 0.93–1.58). Subgroup analysis showed that gender differences, ethnicity differences and the characteristic of the tumor (benign or malignant) did not make much change in the association between brain tumor and PD.</p><p>Conclusions</p><p>Our meta-analysis collecting epidemiological studies suggested a positive association of PD with brain tumors, while the influence of anti-parkinson drugs and ascertainment bias could not be excluded. Further studies with larger sample size and more strict inclusion criteria should be conducted in the future.</p></div

PRISMA flow chart of literature searches and results.

<p>PRISMA flow chart of literature searches and results.</p

Pooled estimation on the risk of brain tumor in PD patients by subgroup analysis.

<p>Pooled estimation on the risk of brain tumor in PD patients by subgroup analysis.</p

Forest plot of ORs for risk of brain tumor among PD patients.

<p>(OR 1.51, 95%CI 1.21–1.89, p<0.001, heterogeneity <i>I</i>^<i>2</i> = 55.7%, p = 0.008) and subgrouped by PD diagnosis time (brain tumor risk before PD, after PD or co-occurrence).</p

Characteristics of Individual Study in the Meta-analysis.

<p>Characteristics of Individual Study in the Meta-analysis.</p

Additional file 2 of Elevated FAM134B expression induces radiation-sensitive in hepatocellular carcinoma

Supplementary Material

Additional file 1 of Elevated FAM134B expression induces radiation-sensitive in hepatocellular carcinoma

Supplementary Material

Additional file 3 of Elevated FAM134B expression induces radiation-sensitive in hepatocellular carcinoma

Supplementary Material