Nasal cellularity in 183 unselected schoolchildren aged 9 to 11 years

Although rhinitis is extremely frequent in children, methods for assessing the severity of nasal inflammation produce results with wide variability and hence weak clinical significance. We designed this epidemiologic investigation to define the clinical usefulness of assessing nasal cellularity in children

Enhancing L2 skills through independent learning: the case study of Italian e-magazine

Engaging students in the learning process of a second language can be challenging and the tutor always needs to find new tools to enhance motivation for learner engagement in and outside the classroom. Starting from our linguistic and journalistic background, we started to create an e-magazine in Italian language (dealing with Italian topics, current affairs in Italy, etc.) with the active involvement of the Italian class students from Upper Intermediate to Proficiency level (B1 to C2). The Italian e-magazine is created within the Department of Languages at Leeds Beckett University to allow students to develop academic skills and to embrace a topic-based linguistic challenge of authentic materials. The students have been deeply engaged in research, reading, discussion and writing in Italian and the results of this experiment have been significantly impactful. The practice of the four skills has resulted in an enrichment of the vocabulary, a development of accuracy and the creation of group works with exchange of opinions. The experience has shown how the flipped classroom experience and the independent learning can interchangeably inform each other. All these activities led to: • Developing motivation • Stimulating interest and curiosity • Engagement in research • Flipped learning Students became active participants in planning and delivering learning activities. They have developed and produced tools in a learner-centred approach, showing a great interest in the idea and a significant improvement in their learning process. “The important practical contribution of the students represents the strength of their engagement in the study of the target language and the involvement in writing as a tool for learning and development” (Ferris D., 2008). It has become clear that this project is going to grow more and more thanks to the enthusiasm of our learners and the support in the group work

Tranexamic acid-loaded mesoporous silica microspheres as a hemostatic material

Bleeding management is considered essential for saving life both in the military and civilian field. There is still a need to develop topical hemostats that can stop bleeding and be used easily in the trauma sites. The aim of this work is to develop a hemostat based on mesoporous silica particles with large pores for bleeding control. Mesoporous silica microspheres (MSM) with particle size of 1.5 − 5 µm and pores diameter of 25 nm have been successfully synthesized and, for the first time, loaded with tranexamic acid (TXA) with a content of 4.7%w/w. The hemostatic activity of both the pure material and TXA-loaded material (TXA@MSM) was investigated. It was found that the blood clotting time was significantly shortened by both systems with respect to control. A hemolysis assay was performed to evaluate the hemolytic activity of MSM, and the result indicated that the material was blood compatible. A preliminary TXA in vitro release test was performed, showing the complete release of TXA from the carrier within one hour. Considering the above results, TXA@MSM can be considered a promising material for the development of new hemostats

Antibacterial β-Glucan/Zinc Oxide Nanocomposite Films for Wound Healing

Advanced antimicrobial biomaterials for wound healing applications are an active field of research for their potential in addressing severe and infected wounds and overcoming the threat of antimicrobial resistance. Beta-glucans have been used in the preparation of these materials for their bioactive properties, but very little progress has been made so far in producing biomedical devices entirely made of beta-glucans and in their integration with effective antimicrobial agents. In this work, a simple and eco-friendly method is used to produce flexible beta-glucan/nanostructured zinc oxide films, using glucans derived from the yeast Saccharomyces cerevisiae. The properties of the films are characterized through scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, infrared and UV–visible spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and water absorption tests. Finally, the antibacterial properties of the nanostructured zinc oxide and of the composite films are assessed against Staphylococcus epidermidis and Escherichia coli, showing a marked effectiveness against the former. Overall, this study demonstrates how a novel bionanocomposite can be obtained towards the development of advanced wound healing devices

Supercritical solvent impregnation of different drugs in mesoporous nanostructured zno

Supercritical solvent impregnation (SSI) is a green unconventional technique for preparing amorphous drug formulations. A mesoporous nanostructured ZnO (mesoNsZnO) carrier with 8-nm pores, spherical-nanoparticle morphology, and an SSA of 75 m2/g has been synthesized and, for the first time, subjected to SSI with poorly water-soluble drugs. Ibuprofen (IBU), clotrimazole (CTZ), and hydrocortisone (HC) were selected as highly, moderately, and poorly CO2-soluble drugs. Powder X-ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, nitrogen adsorption analysis, and ethanol extraction coupled with ultraviolet spectroscopy were employed to characterize the samples and quantify drug loading. Successful results were obtained with IBU and CTZ while HC loading was negligible, which could be related to different solubilities in CO2, drug size, and polarity. Successful SSI resulted in amorphous multilayer confinement of the drug. The mesoNsZnO-IBU system showed double drug loading than the mesoNsZnO-CTZ one, with a maximum uptake of 0.24 g/g. Variation of contact time during SSI of the mesoNsZnO-IBU system showed that drug loading triplicated between 3 and 8 h with an additional 30% increment between 8 h and 24 h. SSI did not affect the mesoNsZnO structure, and the presence of the adsorbed drug reduced the chemisorption of CO2 on the carrier surface

A strontium isoscape of Italy for provenance studies

We present a novel database of biological and geological 87Sr/86Sr values (n = 1920) from Italy, using literature data and newly analysed samples, for provenance purposes. We collected both bioavailable and non-bioavailable (i.e. rocks and bulk soils) data to attain a broader view of the Sr isotope variability of the Italian territory. These data were used to build isotope variability maps, namely isoscapes, through Kriging interpolations. We employed two different Kriging models, namely Ordinary Kriging and Universal Kriging, with a geolithological map of Italy categorized in isotope classes as external predictor. Model performances were evaluated through a 10-fold cross validation, yielding accurate 87Sr/86Sr predictions with root mean squared errors (RMSE) ranging between 0.0020 and 0.0024, dependent on the Kriging model and the sample class. Overall, the produced maps highlight a heterogeneous distribution of the 87Sr/86Sr across Italy, with the highest radiogenic values (>0.71) mainly localized in three areas, namely the Alps (Northern Italy), the Tuscany/Latium (Central Italy) and Calabria/Sicily (Southern Italy) magmatic/metamorphic terrains. The rest of the peninsula is characterized by values ranging between 0.707 and 0.710, mostly linked to sedimentary geological units of mixed nature. Finally, we took advantage of the case study of Fratta Polesine, to underscore the importance of choosing appropriate samples when building the local isoscape and of exploring different end-members when interpreting the local Sr isotope variability in mobility and provenance studies. Our user-friendly maps and database are freely accessible through the Geonode platform and will be updated over time to offer a state-of-the-art reference in mobility and provenance studies across the Italian landscape

Improving working conditions and job satisfaction in healthcare. A study concept design on a participatory organizational level intervention in psychosocial risks management

This paper contributes to the literature on organizational interventions on occupational health by presenting a concept study design to test the efficacy of a Participatory Organizational level Intervention to improve working conditions and job satisfaction in Healthcare. The Participatory Organizational-level Intervention is developed using the Italian methodology to assess and manage psychosocial risks tailored to Healthcare. We added an additional step; evaluation, aiming to examine how the intervention works, what worked for whom in which circumstances. This ongoing study is conducted in collaboration with two large Italian Hospitals (more than 7,000 employees). The study design comprises a quasi-experimental approach consisting of five phases and surveys distributed pre- and post-intervention aiming to capture improvements in working conditions and job satisfaction. Moreover, to evaluate the efficacy of the Intervention in terms of process and content, we use a realist evaluation to test Context-Mechanisms-Outcome (CMO) configurations. We collect contextual factors at baseline and during and post-intervention process data on the key principles of line manager support and employees participation. This study is expected to provide insights on methods and strategies to improve working conditions and employees’ job satisfaction and on national policies in the occupational health framework

Self-Diffusion in Random-Tiling Quasicrystals

The first explicit realization of the conjecture that phason dynamics leads to self-diffusion in quasicrystals is presented for the icosahedral Ammann tilings. On short time scales, the transport is found to be subdiffusive with the exponent $\beta\approx0.57(1)$, while on long time scales it is consistent with normal diffusion that is up to an order of magnitude larger than in the typical room temperature vacancy-assisted self-diffusion. No simple finite-size scaling is found, suggesting anomalous corrections to normal diffusion, or existence of at least two independent length scales.Comment: 11 pages + 2 figures, COMPRESSED postscript figures available by anonymous ftp to black_hole.physics.ubc.ca directory outgoing/diffuse (use bi for binary mode to transfer), REVTeX 3.0, CTP-TAMU 21/9