A Genome Scan for Modifiers of Age at Onset in Huntington Disease: The HD MAPS Study

Huntington disease (HD) is caused by the expansion of a CAG repeat within the coding region of a novel gene on 4p16.3. Although the variation in age at onset is partly explained by the size of the expanded repeat, the unexplained variation in age at onset is strongly heritable (h(2)=0.56), which suggests that other genes modify the age at onset of HD. To identify these modifier loci, we performed a 10-cM density genomewide scan in 629 affected sibling pairs (295 pedigrees and 695 individuals), using ages at onset adjusted for the expanded and normal CAG repeat sizes. Because all those studied were HD affected, estimates of allele sharing identical by descent at and around the HD locus were adjusted by a positionally weighted method to correct for the increased allele sharing at 4p. Suggestive evidence for linkage was found at 4p16 (LOD=1.93), 6p21–23 (LOD=2.29), and 6q24–26 (LOD=2.28), which may be useful for investigation of genes that modify age at onset of HD

Limits to gauge coupling in the dark sector set by the non-observation of instanton-induced decay of Super-Heavy Dark Matter in the Pierre Auger Observatory data

We investigate instanton-induced decay processes of super-heavy dark matter particles $X$ produced during the inflationary epoch. Using data collected at the Pierre Auger Observatory we derive a bound on the reduced coupling constant of gauge interactions in the dark sector: $\alpha_X^{\rm eff} \lesssim 0.09$, for $10^{10} < M_X/{\rm GeV} < 10^{16}$. We show that this upper limit on $\alpha_X^{\rm eff}$ is complementary to that obtained from the non-observation of tensor modes in the cosmic microwave background

Limits to gauge coupling in the dark sector set by the non-observation of instanton-induced decay of Super-Heavy Dark Matter in the Pierre Auger Observatory data

We investigate instanton-induced decay processes of super-heavy dark matter particles $X$ produced during the inflationary epoch. Using data collected at the Pierre Auger Observatory we derive a bound on the reduced coupling constant of gauge interactions in the dark sector: $\alpha_X^{\rm eff} \lesssim 0.09$, for $10^{10} < M_X/{\rm GeV} < 10^{16}$. We show that this upper limit on $\alpha_X^{\rm eff}$ is complementary to that obtained from the non-observation of tensor modes in the cosmic microwave background

Limits to gauge coupling in the dark sector set by the non-observation of instanton-induced decay of Super-Heavy Dark Matter in the Pierre Auger Observatory data

We investigate instanton-induced decay processes of super-heavy dark matter particles $X$ produced during the inflationary epoch. Using data collected at the Pierre Auger Observatory we derive a bound on the reduced coupling constant of gauge interactions in the dark sector: $\alpha_X^{\rm eff} \lesssim 0.09$, for $10^{10} < M_X/{\rm GeV} < 10^{16}$. We show that this upper limit on $\alpha_X^{\rm eff}$ is complementary to that obtained from the non-observation of tensor modes in the cosmic microwave background

Limits to gauge coupling in the dark sector set by the non-observation of instanton-induced decay of Super-Heavy Dark Matter in the Pierre Auger Observatory data

We investigate instanton-induced decay processes of super-heavy dark matter particles $X$ produced during the inflationary epoch. Using data collected at the Pierre Auger Observatory we derive a bound on the reduced coupling constant of gauge interactions in the dark sector: $\alpha_X^{\rm eff} \lesssim 0.09$, for $10^{10} < M_X/{\rm GeV} < 10^{16}$. We show that this upper limit on $\alpha_X^{\rm eff}$ is complementary to that obtained from the non-observation of tensor modes in the cosmic microwave background