Schistosomal hepatic fibrosis and the interferon gamma receptor: a linkage analysis using single-nucleotide polymorphic markers

A minority of individuals infected with the parasite Schistosoma mansoni develops hepatic fibrosis. HLA studies in Egypt and a candidate gene search in a Sudanese population indicate that the host's genetics contribute to disease susceptibility. In an Egyptian community, 32.7% of individuals 11 years and older had significant fibrosis by WHO ultrasound criteria. Linkage to 10 candidate genes was tested using 89 affected sibling pairs from 40 pedigrees in this community. The candidates included genes that initiate fibrosis, participate in collagen synthesis, or control collagen degradation. Two to four single-nucleotide polymorphisms (SNPs) were genotyped per locus, and 188 individuals were genotyped at 48 markers. Model-free modified Haseman-Elston analysis identified linkage to a SNP in the interferon gamma receptor locus (P ¼ 0.000001). There was also weak evidence for linkage to the interleukin 13-4 region and tissue growth factor beta 1

Statistical Learning in Chip (SLIC) (Invited Paper)

Abstract-Despite best efforts, integrated systems are "born" (manufactured) with a unique 'personality' that stems from our inability to precisely fabricate their underlying circuits, and create software a priori for controlling the resulting uncertainty. It is possible to use sophisticated test methods to identify the bestperforming systems but this would result in unacceptable yields and correspondingly high costs. The system personality is further shaped by its environment (e.g., temperature, noise and supply voltage) and usage (i.e., the frequency and type of applications executed), and since both can fluctuate over time, so can the system's personality. Systems also "grow old" and degrade due to various wear-out mechanisms (e.g., negative-bias temperature instability), and unexpectedly due to various early-life failure sources. These "nature and nurture" influences make it extremely difficult to design a system that will operate optimally for all possible personalities. To address this challenge, we propose to develop statistical learning in-chip (SLIC). SLIC is a holistic approach to integrated system design based on continuously learning key personality traits on-line, for selfevolving a system to a state that optimizes performance hierarchically across the circuit, platform, and application levels. SLIC will not only optimize integrated-system performance but also reduce costs through yield enhancement since systems that would have before been deemed to have weak personalities (unreliable, faulty, etc.) can now be recovered through the use of SLIC

The Early Detection and Case Management of Skin Diseases With an mHealth App (eSkinHealth): Protocol for a Mixed Methods Pilot Study in Côte d’Ivoire

Background: There is a high prevalence of skin diseases sub-Saharan Africa, including skin neglected tropical diseases (NTDs) that could lead to lifelong disabilities and deformities if not diagnosed and treated early. To achieve early detection and early treatment of these skin diseases, we developed a mobile health app, eSkinHealth.Objective: This paper outlines a protocol for evaluating the effect of our eSkinHealth app in the early detection and effective management of skin diseases in Côte d’Ivoire.Methods: A mixed methods pilot trial will be conducted in Côte d’Ivoire and will consist of 3 phases: (1) the development and improvement of the eSkinHealth app, (2) a pilot trial to evaluate the usability of the eSkinHealth app for local medical staff in Côte d’Ivoire, and (3) a pilot trial to evaluate the effectiveness of early detection and case management of targeted skin NTDs (Buruli ulcer, leprosy, yaws, and lymphatic filariasis) with the eSkinHealth app in Côte d’Ivoire. The pilot study will be implemented as a 2-arm trial with local health care providers and patients with skin NTDs over a 3-month follow-up period. The local health care providers will be assigned to an intervention group receiving the eSkinHealth app to be used in their daily practices or a control group. Training will be provided on the use and implementation of the app and the diagnostic pipeline to the intervention group only, while both groups will receive training on skin diseases. Our primary outcome is to evaluate the early detection and effective management of skin diseases using the eSkinHealth app in Côte d’Ivoire by the number of cases diagnosed and managed. Additionally, we will evaluate the eSkinHealth app with validated questionnaires and in-depth interviews. Procedures of our methods have been reviewed and approved by the Institutional Review Board of the Ministry of Health, Côte d’Ivoire and by Tulane University in 2021.Results: This study was funded in 2021. We started the enrollment of patients in February 2022, and data collection is currently underway. We expect the first results to be submitted for publication in 2023.Conclusions: Our eSkinHealth app is a field-adapted platform that could provide both direct diagnostic and management assistance to health workers in remote settings. The study will provide evidence for the usability and the effectiveness of the eSkinHealth app to improve the early detection and case management of skin NTDs in Côte d’Ivoire and, furthermore, is expected to contribute to knowledge on mobile health approaches in the control of skin NTDs

Stakeholder Theory and Marketing: Moving from a Firm-Centric to a Societal Perspective

This essay is inspired by the ideas and research examined in the special section on “Stakeholder Marketing” of the Journal of Public Policy & Marketing in 2010. The authors argue that stakeholder marketing is slowly coalescing with the broader thinking that has occurred in the stakeholder management and ethics literature streams during the past quarter century. However, the predominant view of stakeholders that many marketers advocate is still primarily pragmatic and company centric. The position advanced herein is that stronger forms of stakeholder marketing that reflect more normative, macro/societal, and network-focused orientations are necessary. The authors briefly explain and justify these characteristics in the context of the growing “prosociety” and “proenvironment” perspectives—orientations that are also in keeping with the public policy focus of this journal. Under the “hard form” of stakeholder theory, which the authors endorse, marketing managers must realize that serving stakeholders sometimes requires sacrificing maximum profits to mitigate outcomes that would inflict major damage on other stakeholders, especially society

The Radio Luminosity Function and Galaxy Evolution in the Coma Cluster

We investigate the radio luminosity function (RLF) and radio source population for two fields within the Coma cluster of galaxies. Our VLA data reach down to log(L) = 20.23 W/Hz for Coma, and we associate 249 sources with optical counterparts from the SDSS. Comprehensive optical spectroscopy identifies 38 of these as members of the Coma cluster, evenly split between AGN and star-forming galaxies (SFG). The radio-detected SFG are the dominant population only for ~21 < log(L) < ~22 W/Hz, an interesting result given that star formation dominates field RLFs for log(L) < ~23. The majority of the radio-detected SFGs have characteristics of starbursts, including high specific star formation rates and optical spectra with strong emission lines. In conjunction with prior studies on post-starburst galaxies within the Coma cluster, this is consistent with a picture in which late-type galaxies entering Coma undergo a starburst prior to a rapid cessation of star formation. Optically bright elliptical galaxies (Mr <= -20.5) make the largest contribution to the radio luminosity function at both the high (log(L) >~ 22.48 W/Hz) and low (log(L) <~ 21 W/Hz) ends. Through a stacking analysis of these optically-bright ellipticals we find that they continue to harbor radio sources down to log(L) = 19.48. However, contrary to published results for the Virgo cluster we find no evidence for the existence of a population of optically faint (Mr ~ -14) dwarf ellipticals hosting strong radio AGN.Comment: 45 pages with 13 figures, accepted for publication in A

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, Parkinson’s disease, and enriched near genes involved in growth pathways including PI3K–AKT signaling. These findings identify biological underpinnings of intracranial volume and provide genetic support for theories on brain reserve and brain overgrowth

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

This work was supported by a restricted research grant of Bayer AG

Oral History Interview with Jack Blanton, June 30, 1970

Interview with a Democratic member of the Texas House of Representatives Jack Blanton, who is also a businessman from Carrollton, Texas. In the interview, Blanton discusses his experiences and personal views as a member of the Sixty-first Legislature. He also expresses his opinions on issues including his personal political philosophies, one-year versus two-year budgets, the Caveness Plan, social legislation, the establishment of the University of Texas at Dallas, the creation of new four-year colleges, unrest on current college campuses, revenue legislation, beer and liquor lobbies, and person legislation. He also comments on Governor Preston Smith