243 research outputs found

    From the Bowels of an Epidemic: AIDS, Human Rights, and International Equity

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    Rethinking Aspects of AIDS Policy

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    HIV Antibody Screening: An Ethical Framework for Evaluating Proposed Programs

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    The acquired immunodeficiency syndrome (AIDS) poses a compelling ethical challenge to medicine, science, public health, the legal system, and our political democracy. This report focuses on one aspect of that challenge: the use of blood tests to identify individuals who have been infected with the retrovirus human immunodeficiency virus (HIV). In this article, we follow the terminology recently proposed by the International Committee on the Taxonomy of Viruses; that is, we use the term human immunodeficiency virus. This replaces the more cumbersome dual terminology of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). The issue is urgent: the tests are already in use and plans to implement them much more broadly are being proposed. The issue is also complex: at stake is a potential conflict between the community\u27s interests in stopping the spread of a devastating disease and in preserving important values of individual liberty and equal rights

    Adaptive Learning in Weighted Network Games

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    This paper studies adaptive learning in the class of weighted network games. This class of games includes applications like research and development within interlinked firms, crime within social networks, the economics of pollution, and defense expenditures within allied nations. We show that for every weighted network game, the set of pure Nash equilibria is non-empty and, generically, finite. Pairs of players are shown to have jointly profitable deviations from interior Nash equilibria. If all interaction weights are either non-negative or non-positive, then Nash equilibria are Pareto inefficient. We show that quite general learning processes converge to a Nash equilibrium of a weighted network game if every player updates with some regularity

    Flexible Office: Assignment of Office Space to Enhance Knowledge Work Productivity

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    Abstract: Even though knowledge management has been around for more than a decade, so far concrete instruments that can be systematically deployed are still rare. This paper presents an optimization solution targeted at flexible management of office space considering knowledge management criteria in order to enhance knowledge work productivity. The paper presents the Flexible Office conceptual model and optimization solution and discusses the theoretical foundation, assumptions and reasoning. A corresponding prototype was field-tested, successfully introduced, evaluated with the help of a series of interviews with users and improved according to their requirements. The paper also reflects on the organisational impact and lessons learned from field test and practical experience

    The Cool Little Kids randomised controlled trial: Population-level early prevention for anxiety disorders

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    Background: The World Health Organization predicts that by 2030 internalising problems (e.g. depression and anxiety) will be second only to HIV/AIDS in international burden of disease. Internalising problems affect 1 in 7 school aged children, impacting on peer relations, school engagement, and later mental health, relationships and employment. The development of early childhood prevention for internalising problems is in its infancy. The current study follows two successful &lsquo;efficacy&rsquo; trials of a parenting group intervention to reduce internalising disorders in temperamentally inhibited preschool children. Cool Little Kids is a population-level randomised trial to determine the impacts of systematically screening preschoolers for inhibition then offering a parenting group intervention, on child internalising problems and economic costs at school entry.Methods/Design: This randomised trial will be conducted within the preschool service system, attended by more than 95% of Australian children in the year before starting school. In early 2011, preschool services in four local government areas in Melbourne, Australia, will distribute the screening tool. The &asymp;16% (n&asymp;500) with temperamental inhibition will enter the trial. Intervention parents will be offered Cool Little Kids, a 6-session group program in the local community, focusing on ways to develop their child&rsquo;s bravery skills by reducing overprotective parenting interactions. Outcomes one and two years post-baseline will comprise child internalising diagnoses and symptoms, parenting interactions, and parent wellbeing. An economic evaluation (costconsequences framework) will compare incremental differences in costs of the intervention versus control children to incremental differences in outcomes, from a societal perspective. Analyses will use the intention-to-treat principle, using logistic and linear regression models (binary and continuous outcomes respectively) to compare outcomes between the trial arms.Discussion: This trial addresses gaps for internalising problems identified in the 2004 World Health Organization Prevention of Mental Disorders report. If effective and cost-effective, the intervention could readily be applied at a population level. Governments consider mental health to be a priority, enhancing the likelihood that an effective early prevention program would be adopted in Australia and internationally.<br /
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