12 research outputs found
Study of intramolecular crosslinking of macromolecules by the monte carlo method. Calculation of the distribution of reactive groups in the polymer chain and molecular weight distribution
Features of the intramolecular cyclization in the radical polymerization of tetrafunctional monomers. The computer experiment
Topological structure of branched polymers at the pregel stage of radical polymerization. Computer experiment
ΠΡΠΎΡΠΈΠ»Ρ Π°Π΄ΠΈΠΏΠΎΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΠΌ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ
Background: Obesity is aΒ major risk factor for diabetes mellitus and cardiovascular diseases. Nevertheless, some obese patients have normal parameters of blood arterial pressure, carbohydrate, and lipid metabolism ("metabolically healthy obesity", MHO).Aim: To study adipocytokine levels and to assess the effect of weight loss on cardiometabolic risk factors in patients with metabolically healthy obesity.Materials and methods: We conducted aΒ comparative analysis of the main metabolic parameters and adipocytokine levels in 44Β female patients with MHO (according to the IDF criteria of the metabolic syndrome, 2005: obese patients with no more than one additional cardiometabolic risk factor) and in 33Β women with metabolically unhealthy obesity (MUHO). We also assessed changes of these indices in the patients who reduced their body weight by β₯ 5%Β at 6Β months.Results: At baseline, body mass index (BMI) and the levels of basal insulin, C-reactive protein (CRP), tumor necrosis factor alfa (TNF-Ξ±), adiponectin and retinol-binding protein-4 (RBP-4) in the MHO and MUHO groups were comparable. AΒ significant difference between these groups was observed for the HOMA index (3.0 and 4.4, respectively; p 0.05), alanine aminotransferase (ALT) (23.49 and 37.39Β U/l; p = 0.001), interleukin-6 (0.76 and 1.5Β pg/ml; p 0.05), chemerin (322.4 and 369.2Β ng/ml; p 0.05), and the duration of obesity (18 and 22.6Β years; p 0.05). At 6Β months, in those MHO patients, who reduced body weight by β₯ 5% of the initial (66%), there was aΒ significant increase of adiponectin by 4.54 Β± 0.83Β Β΅g/ml (p 0.05) and aΒ reduction of waist circumference (WC) by -8.6 Β± 1Β cm (p 0.05), ΠΠΠΠ index by -1.13 Β± 0.42 (p 0.05), CRP by -1.7 Β± 0.4Β mg/l (p 0.05), RBP-4 by 2.9 Β± 1.0Β ng/ml (p 0.05), and Ρhemerin by -46.6 Β± 17.0Β ng/ml (p 0.05). In the MHO group, we found aΒ positive correlation between changes in the adiponectin levels and the degree of reduction in body weight (p 0.01), changes in RBP-4 and WC (p 0.05), and changes in the levels of interleukin-6 and high-density lipoprotein (p 0.05).Conclusion: Compared to the complicated obesity, MHO is associated with aΒ shorter disease history, and lower levels of the HOMA index, interleukin-6, and chemerin levels. The body mass decrease in MHO is associated with aΒ decrease in the proinflammatory adipocytokine levels and of the HOMA index that determines the need for treatment of obesity, regardless of its phenotype.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΠΆΠΈΡΠ΅Π½ΠΈΠ΅Β β Π²Π°ΠΆΠ½Π΅ΠΉΡΠΈΠΉ ΡΠ°ΠΊΡΠΎΡ ΡΠΈΡΠΊΠ° ΡΠ°Ρ
Π°ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΠ°Π±Π΅ΡΠ° ΠΈΒ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. Π’Π΅ΠΌ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ ΡΡΠ΄ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΈΠΌΠ΅ΡΡ ΡΠΎΡ
ΡΠ°Π½Π½ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ, ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ, Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½ΠΎΠ²Β β Β«ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΠΎΠ΅ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅Β» (MΠO).Π¦Π΅Π»ΡΒ β ΠΈΠ·ΡΡΠΈΡΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π°Π΄ΠΈΠΏΠΎΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ², ΠΎΡΠ΅Π½ΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° Π½Π° ΡΠ°ΠΊΡΠΎΡΡ ΠΊΠ°ΡΠ΄ΠΈΠΎΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ° ΡΒ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΒ ΠΠΠ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈΒ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ, ΡΡΠΎΠ²Π½Ρ Π°Π΄ΠΈΠΏΠΎΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² ΡΒ 44Β ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ ΡΒ MΠO (Ρ ΡΡΠ΅ΡΠΎΠΌ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΠΏΠΎ International Diabetes Federation (2005)Β β ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ ΡΒ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ, ΠΈΠΌΠ΅ΡΡΠΈΠ΅ Π½Π΅ Π±ΠΎΠ»Π΅Π΅ ΠΎΠ΄Π½ΠΎΠ³ΠΎ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° ΠΊΠ°ΡΠ΄ΠΈΠΎΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ°) ΠΈΒ 33Β ΠΆΠ΅Π½ΡΠΈΠ½ ΡΒ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈ Π½Π΅Π·Π΄ΠΎΡΠΎΠ²ΡΠΌ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ (ΠΠΠ). ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΡΠΊΠ°Π·Π°Π½Π½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΒ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ, ΡΠ½ΠΈΠ·ΠΈΠ²ΡΠΈΡ
ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° Π½Π° β₯ 5% ΡΠ΅ΡΠ΅Π· 6Β ΠΌΠ΅ΡΡΡΠ΅Π².Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΡ
ΠΎΠ΄Π½ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°, Π±Π°Π·Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΠΈΠ½Π°, Π‘-ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ°, ΡΠ°ΠΊΡΠΎΡΠ° Π½Π΅ΠΊΡΠΎΠ·Π° ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ-Ξ±, Π°Π΄ΠΈΠΏΠΎΠ½Π΅ΠΊΡΠΈΠ½Π° ΠΈΒ ΡΠ΅ΡΠΈΠ½ΠΎΠ»ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠ΅Π³ΠΎ Π±Π΅Π»ΠΊΠ°-4 Π±ΡΠ»ΠΈ ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΡ Π²Β Π³ΡΡΠΏΠΏΠ°Ρ
MΠO ΠΈΒ MΠΠ. Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠΈΠΌΠΈ Π³ΡΡΠΏΠΏΠ°ΠΌΠΈ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ ΠΏΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌ ΠΈΠ½Π΄Π΅ΠΊΡΠ° HOMAΒ β 3,0 ΠΈΒ 4,4 (Ρ 0,05), Π°Π»Π°Π½ΠΈΠ½Π°ΠΌΠΈΠ½ΠΎΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·ΡΒ β 23,49 ΠΈΒ 37,39Β ΠΠ΄/Π» (p = 0,001), ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-6Β β 0,76 ΠΈΒ 1,85Β ΠΏΠ³/ΠΌΠ» (Ρ 0,05), Ρ
Π΅ΠΌΠ΅ΡΠΈΠ½Π°Β β 322,4 ΠΈΒ 369,2Β Π½Π³/ΠΌΠ» (Ρ 0,05), Π°Β ΡΠ°ΠΊΠΆΠ΅ ΠΏΠΎ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΡΒ β 18 ΠΈΒ 22,6Β Π³ΠΎΠ΄Π° (Ρ 0,05) ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ. Π§Π΅ΡΠ΅Π· 6Β ΠΌΠ΅ΡΡΡΠ΅Π² Π²Β Π³ΡΡΠΏΠΏΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ ΡΒ MΠO, ΡΠ½ΠΈΠ·ΠΈΠ²ΡΠΈΡ
ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° Π½Π° β₯ 5%Β ΠΎΡ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠΉ (66%), Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π°Π΄ΠΈΠΏΠΎΠ½Π΅ΠΊΡΠΈΠ½Π° Π½Π° 4,54 Β± 0,83Β ΠΌΠΊΠ³/ΠΌΠ» (p 0,05), ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΠΊΡΡΠΆΠ½ΠΎΡΡΠΈ ΡΠ°Π»ΠΈΠΈΒ β 8,6 Β± 1Β ΡΠΌ (p 0,005), ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΠΠΠΠΒ β -1,13 Β± 0,42Β (p 0,05), Π‘-ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ°Β β 1,7 Β± 0,4Β ΠΌΠ³/Π» (Ρ 0,05), ΡΠ΅ΡΠΈΠ½ΠΎΠ»ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠ΅Π³ΠΎ Π±Π΅Π»ΠΊΠ°-4Β β 2,9 Β± 1,0Β Π½Π³/ΠΌΠ» (Ρ 0,05) ΠΈΒ Ρ
Π΅ΠΌΠ΅ΡΠΈΠ½Π°Β β 46,6 Β± 17,0Β Π½Π³/ΠΌΠ» (Ρ 0,05). ΠΡ ΠΎΡΠΌΠ΅ΡΠΈΠ»ΠΈ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌΠΈ ΡΡΠΎΠ²Π½Ρ Π°Π΄ΠΈΠΏΠΎΠ½Π΅ΠΊΡΠΈΠ½Π° ΠΈΒ ΡΡΠ΅ΠΏΠ΅Π½ΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° (p 0,01), ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌΠΈ ΡΠ΅ΡΠΈΠ½ΠΎΠ»ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠ΅Π³ΠΎ Π±Π΅Π»ΠΊΠ°-4 ΠΈΒ ΠΎΠΊΡΡΠΆΠ½ΠΎΡΡΠΈ ΡΠ°Π»ΠΈΠΈ (p 0,05) ΠΈΒ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌΠΈ ΡΡΠΎΠ²Π½Π΅ΠΉ ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-6 ΠΈΒ Π»ΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΎΠ² Π²ΡΡΠΎΠΊΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ (p 0,05) Π²Β Π³ΡΡΠΏΠΏΠ΅ MΠO.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΒ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΡΠΌ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΠΠ Π°ΡΡΠΎΡΠΈΠΈΡΡΠ΅ΡΡΡ ΡΒ Π±ΠΎΠ»Π΅Π΅ ΠΊΠΎΡΠΎΡΠΊΠΈΠΌ Π°Π½Π°ΠΌΠ½Π΅Π·ΠΎΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΠΠΠΠ, ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-6, Ρ
Π΅ΠΌΠ΅ΡΠΈΠ½Π°. Π‘Π½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° ΠΏΡΠΈ ΠΠΠ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π°Π΄ΠΈΠΏΠΎΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² ΠΈΒ ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΠΠΠΠ, ΡΡΠΎ ΠΏΡΠ΅Π΄ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΡ Π²Π½Π΅ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΠ΅Π½ΠΎΡΠΈΠΏΠ°