14 research outputs found

    The effect of signal combinations differs from the sum of their effects in isolation.

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    <p>The expression profile of 264 QS regulated genes are plotted, comparing the sum of the individual effects of two signals (C4-HSL and 3-oxo-C12-HSL) with the effect of adding them in combination. The dotted line at 0 represents the summed null expectation and the points represent the difference between the null expectation and the effect of adding both signals. The points are coloured in black if they differ from the null expectation more than would be expected by chance (see Materials and Procedure). In 17 of these the effect of adding both signals exceeded the summed expectation and in 1 case the summed expectation exceeded the observed expression. Gene expression is normalised per gene and gene expression is given in units of standard deviation. The histogram on the right represents the distribution of differences between the null expectation (sum) and the effect of adding both signals.</p
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