2,818 research outputs found
ixpeobssim: a Simulation and Analysis Framework for the Imaging X-ray Polarimetry Explorer
ixpeobssim is a simulation and analysis framework, based on the Python
programming language and the associated scientific ecosystem, specifically
developed for the Imaging X-ray Polarimetry Explorer (IXPE). Given a source
model and the response functions of the telescopes, it is designed to produce
realistic simulated observations, in the form of event lists in FITS format,
containing a strict super-set of the information provided by standard IXPE
level-2 files. The core ixpeobssim simulation capabilities are complemented by
a full suite of post-processing applications, allowing for the implementation
of complex, polarization-aware analysis pipelines, and facilitating the
inter-operation with the standard visualization and analysis tools
traditionally in use by the X-ray community. We emphasize that, although a
significant part of the framework is specific to IXPE, the modular nature of
the underlying implementation makes it potentially straightforward to adapt it
to different missions with polarization capabilities.Comment: 12 pages, 6 figures. Accepted for publication on SoftwareX; source
code available at https://github.com/lucabaldini/ixpeobssi
HIV Testing for Children in Resource-Limited Settings: What Are We Waiting For?
Scott Kellerman and Shaffiq Essajee argue that the time has come to increase access to HIV testing for children, especially in sub-Saharan Africa
Low energy polarization sensitivity of the Gas Pixel Detector
An X-ray photoelectric polarimeter based on the Gas Pixel Detector has been
proposed to be included in many upcoming space missions to fill the gap of
about 30 years from the first (and to date only) positive measurement of
polarized X-ray emission from an astrophysical source. The estimated
sensitivity of the current prototype peaks at an energy of about 3 keV, but the
lack of readily available polarized sources in this energy range has prevented
the measurement of detector polarimetric performances.
In this paper we present the measurement of the Gas Pixel Detector
polarimetric sensitivity at energies of a few keV and the new, light, compact
and transportable polarized source that was devised and built to this aim.
Polarized photons are produced, from unpolarized radiation generated with an
X-ray tube, by means of Bragg diffraction at nearly 45 degrees.
The employment of mosaic graphite and flat aluminum crystals allow the
production of nearly completely polarized photons at 2.6, 3.7 and 5.2 keV from
the diffraction of unpolarized continuum or line emission. The measured
modulation factor of the Gas Pixel Detector at these energies is in good
agreement with the estimates derived from a Monte Carlo software, which was up
to now employed for driving the development of the instrument and for
estimating its low energy sensitivity. In this paper we present the excellent
polarimetric performance of the Gas Pixel Detector at energies where the peak
sensitivity is expected. These measurements not only support our previous
claims of high sensitivity but confirm the feasibility of astrophysical X-ray
photoelectric polarimetry.Comment: 15 pages, 12 figures. Accepted for publication in NIM
Research priorities for improving infant and young child feeding in humanitarian emergencies
Background
There are many challenges during emergencies to ensure that optimal infant and young child feeding is protected, promoted and supported, but there is a dearth of evidence on strategies and programmes to improve Infant and Young Child Feeding in Emergencies (IYCF-E) and a need to determine research priorities.
Methods
Based on interviews with key informants who are experts in the subject, we developed a list of 48 research questions on IYCF-E. A framework, following the Child Health and Nutrition Research Initiative method to set priorities in child health research, was developed to rank the research questions. Four criteria were applied to create a ranking based on answerability, operational relevance, disease burden reduction and prevention, and originality. Using an on-line survey, prioritisation of research questions was done by 27 people from 14 NGOs, universities and research institutions, and UN organisations.
Results
The top-ten research questions identified focused on the following:
• Use of cash-transfer to buy breast-milk substitutes;
• Effectiveness of complementary feeding strategies;
• Long-term effect of IYCF-E interventions;
• Design of IYCF-E programmes in a context where breastfeeding rates are low and breast milk substitutes use is high;
• Design of effective re-lactation interventions;
• Provision of psychological support to young children’s care-takers;
• Determination of number of beneficiaries and coverage of IYCF-E programmes;
• Pros and cons of distributing ready-to-use infant formula compared with distributing powdered infant formula plus kit for safer use of BMS, when use of infant formula is necessary;
• Assessment of the impact of specific IYCF-E programmes on nutritional status, morbidity and mortality;
• Linking and mainstreaming IYCF-E interventions with other sectors such as health, WASH, food security and child protection.
Conclusion
The questions found by this study could form the basis of future research on IYCF-E and could be integrated into the agenda of relevant stakeholders. Results of studies based on these questions will be fundamental to fill the evidence gap in IYCF-E, improve IYCF-E programming and ultimately contribute to the reduction in morbidity and mortality among infants and young children in humanitarian emergencies
A public health approach for deciding policy on infant feeding and mother–infant contact in the context of COVID-19
The COVID-19 pandemic has raised concern about the possibility and effects of mother–infant transmission of SARS-CoV-2 through breastfeeding and close contact. The insufficient available evidence has resulted in differing recommendations by health professional associations and national health authorities. We present an approach for deciding public health policy on infant feeding and mother–infant contact in the context of COVID-19, or for future emerging viruses, that balances the risks that are associated with viral infection against child survival, lifelong health, and development, and also maternal health. Using the Lives Saved Tool, we used available data to show how different public health approaches might affect infant mortality. Based on existing evidence, including population and survival estimates, the number of infant deaths in low-income and middle-income countries due to COVID-19 (2020–21) might range between 1800 and 2800. By contrast, if mothers with confirmed SARS-CoV-2 infection are recommended to separate from their newborn babies and avoid or stop breastfeeding, additional deaths among infants would range between 188 000 and 273 000
TGF-beta reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells
Many lines of evidence have indicated that both genetic and non-genetic determinants can contribute to intra-tumor heterogeneity and influence cancer outcomes. Among the best described sub-population of cancer cells generated by non-genetic mechanisms are cells characterized by a CD44+/CD24- cell surface marker profile. Here, we report that human CD44+/CD24- cancer cells are genetically highly unstable due to intrinsic defects in their DNA repair capabilities. In fact, in CD44+/CD24- cells constitutive activation of the TGF-beta axis was both necessary and sufficient to reduce the expression of genes that are critical in coordinating DNA damage repair mechanisms. Consequently, we observed that cancer cells that reside in a CD44+/CD24- state are characterized by increased accumulation of DNA copy number alterations, greater genetic diversity and improved adaptability to drug treatment. Together, these data suggest that the transition into a CD44+/CD24- cell state can promote intra-tumor genetic heterogeneity, spur tumor evolution and increase tumor fitness
Early pyloric stenosis: a case control study
Pyloric stenosis (PS) is rare in the first 2Â weeks of life, often leading to delays in diagnosis and treatment. We conducted a case control study to delineate the characteristics of patients with early PS (EPS). In addition, we tested the hypothesis that patients with EPS present with a smaller pylorus than older patients.
A database of all patients presenting with PS to a children’s hospital over a 5-year period (2002–2006) was obtained. Each patient admitted during the first 2 weeks of life (subject) was matched to a patient admitted after 4 weeks of age (control), with the same gender, electrolyte status, and treating surgeon. A single pediatric radiologist, blinded to patient age, reviewed all available ultrasounds retrospectively. Demographic, clinical, diagnostic, therapeutic, and outcome data were compared.
During the study period, 278 pyloromyotomies were performed for PS. Sixteen patients (5.8%) presented with EPS between 2 and 14 days of life. EPS patients had a higher prevalence of positive family history (31 vs. 0%, P = 0.043), and breast milk feeding (75 vs. 31%, P = 0.045). Sonographic measurements showed a pylorus that was of significantly less length (17.1 ± 0.6 vs. 20.5 ± 0.9 mm, P = 0.006) and muscle thickness (3.5 ± 0.2 vs. 4.9 ± 0.2 mm, P < 0.001) in patients with EPS. Hospital stay was significantly longer for EPS patients (4.3 ± 0.9 vs. 2.0 ± 0.1 days, P = 0.19)
Babies presenting with EPS are more likely to be breast fed and to have a positive family history. EPS is associated with a longer hospital stay. Use of sonographic diagnostic measurements specific to this age group may prevent delays in diagnosis and treatment, and improve outcomes
- …