The experiences of women with polycystic ovary syndrome on a very low-calorie diet

The research was funded by an educational grant from LighterLife. Broom was the Medical Director for LighterLife at the time of the research. Johnson is the Head of Nutrition and Research at LighterLife. The authors report no other conflicts of interest in this work.Peer reviewedPublisher PD

Inverse Compton Scenarios for the TeV Gamma-Ray Emission of the Galactic Centre

The intense Compton cooling of ultra-relativistic electrons in the Klein-Nishina regime in radiation dominated environments, such as that found in the Galactic Centre, may result in radically different electron spectra than those produced by Synchrotron cooling. We explore these effects and their impact on the X-ray and gamma-ray spectra produced in electron accelerators in this region in comparison to elsewhere in our galaxy. We discuss the broad-band emission expected from the newly discovered pulsar wind nebula G 359.95-0.04 and the possible relationship of this X-ray source to the central TeV gamma-ray source HESS J1745-290. Finally we discuss the possible relationship of the Galactic Centre INTEGRAL source IGR J1745.6-2901 to the TeV emission.Comment: 10 pages, 7 figures, to appear in ApJ 65

Frozen shuffle update for an asymmetric exclusion process on a ring

We introduce a new rule of motion for a totally asymmetric exclusion process (TASEP) representing pedestrian traffic on a lattice. Its characteristic feature is that the positions of the pedestrians, modeled as hard-core particles, are updated in a fixed predefined order, determined by a phase attached to each of them. We investigate this model analytically and by Monte Carlo simulation on a one-dimensional lattice with periodic boundary conditions. At a critical value of the particle density a transition occurs from a phase with `free flow' to one with `jammed flow'. We are able to analytically predict the current-density diagram for the infinite system and to find the scaling function that describes the finite size rounding at the transition point.Comment: 16 page

Accurate calibration of test mass displacement in the LIGO interferometers

We describe three fundamentally different methods we have applied to calibrate the test mass displacement actuators to search for systematic errors in the calibration of the LIGO gravitational-wave detectors. The actuation frequencies tested range from 90 Hz to 1 kHz and the actuation amplitudes range from 1e-6 m to 1e-18 m. For each of the four test mass actuators measured, the weighted mean coefficient over all frequencies for each technique deviates from the average actuation coefficient for all three techniques by less than 4%. This result indicates that systematic errors in the calibration of the responses of the LIGO detectors to differential length variations are within the stated uncertainties.Comment: 10 pages, 6 figures, submitted on 31 October 2009 to Classical and Quantum Gravity for the proceedings of 8th Edoardo Amaldi Conference on Gravitational Wave

Hybrid in vitro diffusion cell for simultaneous evaluation of hair and skin decontamination: temporal distribution of chemical contaminants

Most casualty or personnel decontamination studies have focused on removing contaminants from the skin. However, scalp hair and underlying skin are the most likely areas of contamination following airborne exposure to chemicals. The aim of this study was to investigate the interactions of contaminants with scalp hair and underlying skin using a hybrid in vitro diffusion cell model. The in vitro hybrid test system comprised “curtains” of human hair mounted onto sections of excised porcine skin within a modified diffusion cell. The results demonstrated that hair substantially reduced underlying scalp skin contamination and that hair may provide a limited decontamination effect by removing contaminants from the skin surface. This hybrid test system may have application in the development of improved chemical incident response processes through the evaluation of various hair and skin decontamination strategies.Peer reviewedFinal Published versio

Simple system using natural mineral water for high-throughput phenotyping of Arabidopsis thaliana seedlings in liquid culture

Background: Phenotyping for plant stress tolerance is an essential component of many research projects. Because screening of high numbers of plants and multiple conditions remains technically challenging and costly, there is a need for simple methods to carry out large-scale phenotyping in the laboratory.Methods: We developed a method for phenotyping the germination and seedling growth of Arabidopsis (Arabidopsis thaliana) Col-0 in liquid culture. Culture was performed under rotary shaking in multiwell plates, using Evian natural mineral water as a medium. Nondestructive and accurate quantification of green pixels by digital image analysis allowed monitoring of growth. Results: The composition of the water prevented excessive root elongation growth that would otherwise lead to clumping of seedlings observed when classic nutrient-rich medium or deionized water is used. There was no need to maintain the cultures under aseptic conditions, and seedlings, which are photosynthetic, remained healthy for several weeks. Several proof-of-concept experiments demonstrated the usefulness of the approach for environmental stress phenotyping. Conclusion: The system described here is easy to set up, cost-effective, and enables a single researcher to screen large numbers of lines under various conditions. The simplicity of the method clearly makes it amenable to high-throughput phenotyping using robotics

Calibration of the LIGO displacement actuators via laser frequency modulation

We present a frequency modulation technique for calibration of the displacement actuators of the LIGO 4-km-long interferometric gravitational-wave detectors. With the interferometer locked in a single-arm configuration, we modulate the frequency of the laser light, creating an effective length variation that we calibrate by measuring the amplitude of the frequency modulation. By simultaneously driving the voice coil actuators that control the length of the arm cavity, we calibrate the voice coil actuation coefficient with an estimated 1-sigma uncertainty of less than one percent. This technique enables a force-free, single-step actuator calibration using a displacement fiducial that is fundamentally different from those employed in other calibration methods.Comment: 10 pages, 5 figures, submitted to Classical and Quantum Gravit

Spontaneous symmetry breaking in a two-lane model for bidirectional overtaking traffic

First we consider a unidirectional flux \omega_bar of vehicles each of which is characterized by its `natural' velocity v drawn from a distribution P(v). The traffic flow is modeled as a collection of straight `world lines' in the time-space plane, with overtaking events represented by a fixed queuing time tau imposed on the overtaking vehicle. This geometrical model exhibits platoon formation and allows, among many other things, for the calculation of the effective average velocity w=\phi(v) of a vehicle of natural velocity v. Secondly, we extend the model to two opposite lanes, A and B. We argue that the queuing time \tau in one lane is determined by the traffic density in the opposite lane. On the basis of reasonable additional assumptions we establish a set of equations that couple the two lanes and can be solved numerically. It appears that above a critical value \omega_bar_c of the control parameter \omega_bar the symmetry between the lanes is spontaneously broken: there is a slow lane where long platoons form behind the slowest vehicles, and a fast lane where overtaking is easy due to the wide spacing between the platoons in the opposite direction. A variant of the model is studied in which the spatial vehicle density \rho_bar rather than the flux \omega_bar is the control parameter. Unequal fluxes \omega_bar_A and \omega_bar_B in the two lanes are also considered. The symmetry breaking phenomenon exhibited by this model, even though no doubt hard to observe in pure form in real-life traffic, nevertheless indicates a tendency of such traffic.Comment: 50 pages, 16 figures; extra references adde