Restricting the nonlinearity parameter in soil greenhouse gas flux calculation for more reliable flux estimates

The static chamber approach is often used for greenhouse gas (GHG) flux measurements, whereby the flux is deduced from the increase of species concentration after closing the chamber. Since this increase changes diffusion gradients between chamber air and soil air, a nonlinear increase is expected. Lateral gas flow and leakages also contribute to non linearity. Several models have been suggested to account for this non linearity, the most recent being the Hutchinson±Mosier regression model (HMR). However, the practical application of these models is challenging because the researcher needs to decide for each flux whether a nonlinear fit is appropriate or exaggerates flux estimates due to measurement artifacts. In the latter case, a flux estimate from the linear model is a more robust solution and introduces less arbitrary uncertainty to the data. We present the new, dynamic and reproducible flux calculation scheme, KAPPA.MAX, for an improved trade-off between bias and uncertainty (i.e. accuracy and precision). We develop a tool to simulate, visualise and optimise the flux calculation scheme for any specific static N2O chamber measurement system. The decision procedure and visualisation tools are implemented in a package for the R software. Finally, we demonstrate with this approach the performance of the applied flux calculation scheme for a measured flux dataset to estimate the actual bias and uncertainty. The KAPPA.MAX method effectively improved the decision between linear and nonlinear flux estimates reducing the bias at a minimal cost of uncertainty

A canvas for the ethical design of learning experiences with digital tools

The use of digital tools has drastically increased in engineering education, accelerated by the COVID-19 pandemic. These tools generate important ethical issues, in particular in terms of privacy and fairness. However, very few teacher training programmes address those topics, which means that teachers are often left to figure out by themselves how to address these issues when they want (or have) to use digital tools in their teaching. In this workshop, participants will be introduced to a pragmatic approach to the ethical design of learning experiences that involve digital tools using a visual thinking guide called a ‘canvas’. Applied and hands-on, this workshop will help participants to develop a practical understanding of the specific ethical issues related to the use of digital tools in teaching and to integrate ethical reflection into design processes when digital technology is involved

Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study

Background. Impaired renal function is evolving as an independent marker of the risk of cardiovascular morbidity and mortality. Little is known about the prevalence of impaired renal function and its relationship to cardiovascular risk factors in the Swiss general population. Methods. SAPALDIA comprises a random sample of the Swiss population established in 1991, originally to investigate the health effects of long-term exposure to air pollution. Participants were reassessed in 2002/3 and blood measurements were obtained (n = 6317). Renal function was estimated using the Cockcroft-Gault equation and the modified MDRD (four-component) equation incorporating age, race, gender and serum creatinine level. Results. The estimated prevalence of impaired renal function [estimated glomerular filtration rate <60 ml/min/1.73 m2] differed substantially between men and women, particularly at higher ages, and amounted to 13% [95% confidence interval (CI) 10-16%] and 36% (95% CI 32-40%) in men and women, respectively, of 65 years or older. Smoking, obesity, blood lipid levels, high systolic blood pressure and hyperuricaemia were all more common in men when compared with women. These cardiovascular risk factors were also associated independently with creatinine in both women and men. Women were less likely to receive cardiovascular drugs, in particular angiotensin-converting enzyme inhibitors and β-blockers, when compared with men of the same age. Conclusion. Moderate renal impairment seems to be prevalent in the general population, with an apparent excess in females which is not explained by conventional cardiovascular risk factors. The unexpected finding questions the validity of the prediction equations, in particular in female

Hematopoietic stem cell transplantation for adolescents and adults with inborn errors of immunity: an EBMT IEWP study.

peer reviewedAllogeneic hematopoietic stem cell transplantation (HSCT) is the gold standard curative therapy for infants and children with many inborn errors of immunity (IEI), but adolescents and adults with IEI are rarely referred for transplant. Lack of published HSCT outcome data outside small, single-center studies and perceived high risk of transplant-related mortality have delayed the adoption of HSCT for IEI patients presenting or developing significant organ damage later in life. This large retrospective, multicenter HSCT outcome study reports on 329 IEI patients (age range, 15-62.5 years at HSCT). Patients underwent first HSCT between 2000 and 2019. Primary endpoints were overall survival (OS) and event-free survival (EFS). We also evaluated the influence of IEI-subgroup and IEI-specific risk factors at HSCT, including infections, bronchiectasis, colitis, malignancy, inflammatory lung disease, splenectomy, hepatic dysfunction, and systemic immunosuppression. At a median follow-up of 44.3 months, the estimated OS at 1 and 5 years post-HSCT for all patients was 78% and 71%, and EFS was 65% and 62%, respectively, with low rates of severe acute (8%) or extensive chronic (7%) graft-versus-host disease. On univariate analysis, OS and EFS were inferior in patients with primary antibody deficiency, bronchiectasis, prior splenectomy, hepatic comorbidity, and higher hematopoietic cell transplant comorbidity index scores. On multivariable analysis, EFS was inferior in those with a higher number of IEI-associated complications. Neither age nor donor had a significant effect on OS or EFS. We have identified age-independent risk factors for adverse outcome, providing much needed evidence to identify which patients are most likely to benefit from HSCT

The Triassic-Jurassic boundary in the shallow-water marine carbonates from the western Northern Calcareous Alps (Austria)

The Triassic-Jurassic (T-J) boundary coincides with one of the five biggest mass extinctions in the Phanerozoic. This event has been extensively studied in the eastern and central Northern Calcareous Alps (NCA), where the global stratotype section and point for the base of the Jurassic is outcropping. We present one of the first combined bio-, litho- and carbonate carbon isotope stratigraphic study across the T-J boundary from the western NCA, focusing on the shallow-water marine carbonate successions "Lorüns” and "Steinernes Meer”. An almost complete T-J succession with the Upper Triassic Kössen Formation, the T-J Schattwald beds and the Lower Jurassic Lorüns oolite is preserved in the Lorüns section, whereas a stratigraphic hiatus at the T-J boundary is observed in the Steinernes Meer section. The carbonate carbon isotope record of Lorüns shows the characteristic T-J carbon isotope evolution with a short initial negative carbon isotope excursion (CIE) in the lower Schattwald beds, which is separated from the following and longer main negative CIE in the Lorüns oolite by a positive excursion in the upper Schattwald beds. The synchroneity of the initial and main CIE with the last occurrence of Triassic fauna and the first appearance of Jurassic ammonites suggests placing the T-J boundary at the base of the Lorüns oolite. The Steinernes Meer section records only the main negative CIE in the Lorüns oolite due to emersion and/or no sedimentation between the Upper Triassic Kössen Formation and the Lower Jurassic Lorüns oolite, caused by regression and synsedimentary tectonics. This study provides new evidence in support the hypothesis that the latest Rhaetian decrease and the Hettangian recovery of the carbonate production coinciding with the initial and main CIE, respectively, can be interpreted as evidence of acidification of the Tethys ocean due to elevated atmospheric CO2 concentrations, probably caused by voluminous volcanic gas emissions

Simulation-based learning influences real-life attitudes

Humans can vividly simulate hypothetical experiences. This ability draws on our memories (e.g., of familiar people and locations) to construct imaginings that resemble real-life events (e.g., of meeting a person at a location). Here, we examine the hypothesis that we also learn from such simulated episodes much like from actual experiences. Specifically, we show that the mere simulation of meeting a familiar person (unconditioned stimulus; US) at a known location (conditioned stimulus; CS) changes how people value the location. We provide key evidence that this simulation-based learning strengthens pre-existing CS-US associations and that it leads to a transfer of valence from the US to the CS. The data thus highlight a mechanism by which we learn from simulated experiences

The Triassic–Jurassic boundary in the shallow-water marine carbonates from the western Northern Calcareous Alps (Austria)

The Triassic–Jurassic (T–J) boundary coincides with one of the five biggest mass extinctions in the Phanerozoic. This event has been extensively studied in the eastern and central Northern Calcareous Alps (NCA), where the global stratotype section and point for the base of the Jurassic is outcropping. We present one of the first combined bio-, litho- and carbonate carbon isotope stratigraphic study across the T–J boundary from the western NCA, focusing on the shallow-water marine carbonate successions “Lorüns” and “Steinernes Meer”. An almost complete T–J succession with the Upper Triassic Kössen Formation, the T–J Schattwald beds and the Lower Jurassic Lorüns oolite is preserved in the Lorüns section, whereas a stratigraphic hiatus at the T–J boundary is observed in the Steinernes Meer section. The carbonate carbon isotope record of Lorüns shows the characteristic T–J carbon isotope evolution with a short initial negative carbon isotope excursion (CIE) in the lower Schattwald beds, which is separated from the following and longer main negative CIE in the Lorüns oolite by a positive excursion in the upper Schattwald beds. The synchroneity of the initial and main CIE with the last occurrence of Triassic fauna and the first appearance of Jurassic ammonites suggests placing the T–J boundary at the base of the Lorüns oolite. The Steinernes Meer section records only the main negative CIE in the Lorüns oolite due to emersion and/or no sedimentation between the Upper Triassic Kössen Formation and the Lower Jurassic Lorüns oolite, caused by regression and synsedimentary tectonics. This study provides new evidence in support the hypothesis that the latest Rhaetian decrease and the Hettangian recovery of the carbonate production coinciding with the initial and main CIE, respectively, can be interpreted as evidence of acidification of the Tethys ocean due to elevated atmospheric CO2 concentrations, probably caused by voluminous volcanic gas emissions