Guía de actividades docentes para la formación en integración e igualdad de oportunidades por razón de discapacidad en las enseñanzas técnicas: accesibilidad universal y diseño para todos

Esta guía se ha promovido desde la Universidad Politécnica de Cataluña (UPC) en un momento caracterizado por la transición a los nuevos grados y másteres. Elaborada con un enfoque práctico y didáctico, quiere ser una herramienta de fácil uso y lectura para el profesorado de las carreras técnicas de cualquier universidad española, aportando ejemplos de aplicación de los principios de diseño para todos y criterios de accesibilidad universal en su práctica docente

Guía de actividades docentes para la formación en integración e igualdad de oportunidades por razón de discapacidad en las enseñanzas técnicas: accesibilidad universal y diseño para todos

Estudio financiado por el MEC, Programa Estudio y AnálisisPostprint (published version

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Influence of the structure of hyaluronan materials on drug delivery properties

Trabajo presentado en el VII Workshop CBN 2015, 7ª Jornada del Departamento de Nanotecnología Química y Biomolecular del IQAC, celebrado en Barcelona el 15 de octubre de 2015

Solid Foams based on hyaluronan as sustained drug delivery systems

Trabajo presentado en la 4th International Conference on Multifunctional, Hybrid and Nanomaterials, celebrada en Sitges (España), entre el 9 y el 12 de septiembre de 2015

Hydrogels and porous materials based on hyaluronan as drug delivery systems

Resumen del trabajo presentado en el 19th International Symposium on Microencapsulation, celebrado en Pamplona (España) entre el 9 y el 11 de septiembre de 2013Hyaluronan (HA) is a natural polysaccharide widely distributed into the human body. Its physicochemical properties and high biocompatibility make it a good candidate for biomedical and pharmaceutical use.1 The aim of this work is to obtain hydrogels and porous materials based on hyaluronan to be used as drug delivery systems. Hydrogels are crosslinked networks of hydrophilic polymers that are very similar to some biological tissues in terms of their physical properties. Highly concentrated emulsions, also known as high internal phase ratio emulsions (HIPRE), are emulsions in which the volume fraction of the dispersed phase is higher than 0.74, the maximum volume fraction of close-packed monodisperse spheres.2 The incorporation of a preformed polymer in the continuous phase of HIPRE allows the preparation of porous materials with very high pore volume.3 In the present work, two types of materials have been obtained by crosslinking HA with butanediol diglycidyl ether (BDDE): a) hydrogels; and b) highly porous foams. The preparation of hydrogels was carried out by mixing HA with crosslinking solutions consisting on BDDE in alkaline media. Transparent and stiff HA hydrogels were prepared, loaded with 2.5% (w/w) of ketoprofen (KP) used as a model drug.4 HA highly porous materials were obtained by crosslinking in the continuous phase of O/W HIPREs. The components of the emulsion were 5% HA aqueous solution, a castor oil derivative as surfactant, and a mixture of caprylic and capric fatty acids. O/W HIPREs were loaded with 2.5% of KP before addition of BDDE solution for HA crosslinking. Both hydrogels and HIPREs based on HA showed high stability. The release properties of the hydrogels and porous materials were studied. Release profiles of KP showed differences as a function of the crosslinking degree of the HA hydrogels. A strong delay in drug release from the porous materials could be observed (Figure 1). The characteristics and differences in KP release profiles, depending on the crosslinking degree of the hydrogels and porous materials, suggest the possibility of obtaining controlled drug delivery systems for biomedical applications.The authors acknowledge financial support to the Spanish Ministerio de Economía y Competitividad, DGI (CTQ 2011-29336-C03/PPQ)Peer reviewe

Design of hyaluronic acid hydrogels: Effect of crosslinker concentration on drug release and toxicity

Trabajo presentado en la 30th Conference of the European Colloid and Interface Society (ECIS 2016), celebrada en Roma (Italia) entre el 4 y el 9 de septiembre de 2016.Hyaluronic acid (HA) is a natural polysaccharide widely distributed into the human body. The physicochemical properties and biocompatibility make it a suitable candidate to be used in biomedical and pharmaceutical applications [1]. As HA is degraded in vivo by hyaluronidase [2], the preparation of materials based on chemically crosslinked HA for drug delivery could represent a useful approach for increasing the in vivo resistance to degradation [3]. Hydrogels are crosslinked networks of hydrophilic polymers. These materials are very similar to biological tissues in terms of their physical properties, due to their high water content and soft consistency. Furthermore, the capacity of hydrogels to contain molecules of different sizes enables using them as drug delivery systems via several administration routes [4,5]. The aim of this work was to study the crosslinking effect of HA hydrogels on drug release properties and in vitro cytotoxicity. HA hydrogels were prepared with different degrees of crosslinking using butanediol diglycidyl ether (BDDE) as a crosslinking agent. A lipophilic model drug, ketoprofen (KP), and a hydrophilic model drug, theophylline (TH), were incorporated to HA hydrogels and the release properties of HA hydrogels as a function of the degree of crosslinking were studied. The results showed that, while a fast release was observed for a low crosslinking degree, a more sustained release was obtained for HA hydrogels with a high degree of crosslinking. The mathematical models applied to fit the experimental values show that the dominant mechanism in the drug release is Fickian diffusion. Furthermore, the MTT test was applied to study hydrogels toxicity and the influence of crosslinker concentration on cells viability was determined. Preliminary results evidenced that HA hydrogels induce low cytotoxicity in HeLa human cell line, showing more than 80% of cell viability. In conclusion, the results obtained on the release properties of HA hydrogels indicate that there are suitable for controlled drug delivery due to the possibility of modifying the crosslinking degree that influence release kinetics. Likewise, in vitro assays show that these materials could be considered as good candidates for implant developments due to their low cytotoxicity.The financial support of the Ministerio de Economía y Competitividad (project CTQ2011-29336-CO3) and the Generalitat de Catalunya (consolidated research group 2014SGR1655)Peer reviewe

Influence of Hyaluronic acid hydrogels composition on drug release and toxicity

Trabajo presentado en el VIII Workshop CBN 2016, 8ª Jornada del Departamento de Nanotecnología Química y Biomolecular del IQAC, celebrado en Barcelona el 20 de octubre de 2016

Hyaluronan based hydrogels as drug delivery systems for cataionic sugar-derived surfactants

Trabajo presentado en la 26th Conference of the European Colloid and Interface Society (ECIS 2012), celebrada en Malmö (Suecia) entre el 2 y el 7 de septiembre de 2012

Influence of crosslinking degree on hyaluronan gel properties and in vitro cytotoxicity

Trabajo presentado en la VII Jornada IN2UB, celebrada en Barcelona el 26 de enero de 2017.Hyaluronan (HA) is a natural polysaccharide widely distributed into the human body that can be used in biomedical and pharmaceutical applications [1]. As HA is degraded in vivo by hyaluronidase [2], the preparation of materials based on chemically crosslinked HA for drug delivery could represent a useful approach for increasing the in vivo resistance to degradation [3]. Hydrogels are crosslinked networks of hydrophilic polymers used as drug delivery systems via several administration routes [4,5]. The aim of this work was to study the crosslinking effect of HA hydrogels on drug release properties and in vitro cytotoxicity. HA hydrogels were prepared with different degrees of crosslinking using butanediol diglycidyl ether (BDDE) as a crosslinking agent. A lipophilic model drug, ketoprofen, and a hydrophilic model drug, theophylline, were incorporated to HA hydrogels and the release properties of HA hydrogels as a function of the degree of crosslinking were studied. The capacity to absorb water decreases dramatically with crosslinker concentration. The results showed that a more sustained release was obtained for HA hydrogels with a high degree of crosslinking. Furthermore, the MTT test was applied to study hydrogels toxicity and the influence of crosslinker concentration on HeLa human cells viability was determined. The results obtained on the release properties of HA hydrogels indicate that there are suitable for controlled drug delivery due to the possibility of modifying the crosslinking degree that influence release kinetics. Likewise, in vitro assays show that these materials could be considered as good candidates for implant developments due to their low cytotoxicity