100 research outputs found

    Annual Meeting of the Washington State Bar Association Preface

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    The Annual Meeting of the Washington State Bar Association was convened in Yakima on September 8 through 10, 1960. The Association of Superior Court Judges and State Judicial Council also convened for their meeting at the same time. We are setting forth herein the program held in conjunction with the annual meeting. The legal institutes were prepared and conducted by the State Bar Association\u27s Committee on Continuing Legal Education, Charles F. Osborn, Chairman. The proceedings which immediately follow the program are only those of the annual business meeting of the State Bar Association

    Annual Meeting of the Washington State Bar Association; Preface

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    The Annual Meeting of the Washington State Bar Association was convened in Tacoma on September 7 through 9, 1961. The Association of Superior Court Judges and State Judicial Council also convened for their meeting at the same time. We are setting forth herein the program held in conjunction with the annual meeting. The legal institutes were prepared and conducted by the State Bar Association\u27s Committee on Continuing Legal Education, Pinckney M. Rohrback, Chairman. The proceedings which immediately follow the program are only those of the annual business meeting of the State Bar Association

    The Lantern Vol. 54, No. 2, Spring 1988

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    • Burning the Christmas Guests • A Song in Time • I Ask a Question • As If Raggedy Anne • One Man\u27s Escape • Gypsy Caravan • Apartment 14B • The College Inferno • Somewhere Under Manhattan • Trumped • Sunday • In Quest of Creativity • Imperfect Healing • The Game • The Hunger • Peanuts on the Beach • Battlefield Prom • Confessions of the Untrained Eye • Animal Attraction • Street Lamps • Hey, Old Man • In Search of Self-Actualization • Cousin Joe Bob\u27s First Visit to Pulsationshttps://digitalcommons.ursinus.edu/lantern/1132/thumbnail.jp

    Single-cell whole-genome sequencing reveals widespread somatic copy number variations in the developing cerebral cortex

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    Somatic genomic mosaicism (SGM) has recently been identified in the brain, however there is not yet a clear consensus on the prevalence or functional ramifications of this phenomenon. In this thesis, I utilized the cutting-edge technology of single-cell whole-genome sequencing (scWGS) to assess the presence of somatic copy number variations (CNVs) throughout cerebral cortical development. I developed and thoroughly validated a robust CNV detection pipeline. This included the use of support vector machine learning algorithms trained on lymphocyte V(D)J recombination to model high quality CNV calls. My approach reduced false discovery rate (FDR) by 91% and identified thousands of somatic CNVs in the cerebral cortex—with 51% under 1 Mb. Analysis of ~400 cells revealed that CNVs are present throughout the genome of individual brain cells and exhibit a strong preference for deletions over amplifications. Importantly, CNV frequency triples from early- to mid-neurogenesis, which may suggest a prenatal origin of CNV diversity. Expanding upon this baseline has indicated that the incidence of somatic CNVs, particularly amplification events, is altered by fetal exposure to ethanol. I anticipate my work will inspire targeted research that will provide further insight into the importance of neuronal SGM in both healthy and diseased brains

    Fred Rohrback Interview, July 21, 1984

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    Fred Rohrback discusses his time as a smokejumper for both the U.S. Forest Service and the U.S. Bureau of Land Management (BLM) from 1965 to 1973. He compares jumping for the different organizations, as well as the differences between working at bases across the western United States and in Alaska. Rohrback describes training at Missoula, Montana, fire jump procedures, and let downs from tree landings. He also comments on some of the changes in the smokejumper program, including the advent of the professional jumper.https://scholarworks.umt.edu/smokejumpers/1017/thumbnail.jp

    A Glance at the Relations between Baltimore's Community Organizations and the City Administration in Physical Planning Issues

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    Citations of sources, conclusions, or opinions expressed in this publication are the responsibility of the author and do not reflect the policies or views of staff or others affiliated with the Institute for Policy Studies or Johns Hopkins University

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