Dissociating contributions of the motor cortex to speech perception and response bias by using transcranial magnetic stimulation

Recent studies using repetitive transcranial magnetic stimulation (TMS) have demonstrated that disruptions of the articulatory motor cortex impair performance in demanding speech perception tasks. These findings have been interpreted as support for the idea that the motor cortex is critically involved in speech perception. However, the validity of this interpretation has been called into question, because it is unknown whether the TMS-induced disruptions in the motor cortex affect speech perception or rather response bias. In the present TMS study, we addressed this question by using signal detection theory to calculate sensitivity (i.e., d′) and response bias (i.e., criterion c). We used repetitive TMS to temporarily disrupt the lip or hand representation in the left motor cortex. Participants discriminated pairs of sounds from a “ba”–“da” continuum before TMS, immediately after TMS (i.e., during the period of motor disruption), and after a 30-min break. We found that the sensitivity for between-category pairs was reduced during the disruption of the lip representation. In contrast, disruption of the hand representation temporarily reduced response bias. This double dissociation indicates that the hand motor cortex contributes to response bias during demanding discrimination tasks, whereas the articulatory motor cortex contributes to perception of speech sounds

The GMAT Analytical Writing Assessment: Opportunitw or Threat for Management Communication?

Instituted as a regular part of the GMAT in October 1994, the Analytical Writing Assessment (AWA) has the potential to serve as a diagnostic tool in MBA programs. This article describes the new test and reviews the uses of the AWA scores and essays that have significant ramifications for management communication. It concludes by suggesting why it is vital for communication instructors to become involved in decisions about how to use the A WA results.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68049/2/10.1177_108056999605900206.pd

Inverting Onto Functions and Polynomial Hierarchy

In this paper we construct an oracle under which the polynomial hierarchy is infinite but there are non-invertible polynomial time computable multivalued onto functions

Local time and the pricing of time-dependent barrier options

A time-dependent double-barrier option is a derivative security that delivers the terminal value $\phi(S_T)$ at expiry $T$ if neither of the continuous time-dependent barriers b_\pm:[0,T]\to \RR_+ have been hit during the time interval $[0,T]$. Using a probabilistic approach we obtain a decomposition of the barrier option price into the corresponding European option price minus the barrier premium for a wide class of payoff functions $\phi$, barrier functions $b_\pm$ and linear diffusions $(S_t)_{t\in[0,T]}$. We show that the barrier premium can be expressed as a sum of integrals along the barriers $b_\pm$ of the option's deltas \Delta_\pm:[0,T]\to\RR at the barriers and that the pair of functions $(\Delta_+,\Delta_-)$ solves a system of Volterra integral equations of the first kind. We find a semi-analytic solution for this system in the case of constant double barriers and briefly discus a numerical algorithm for the time-dependent case.Comment: 32 pages, to appear in Finance and Stochastic

Women, men and coronary heart disease: a review of the qualitative literature

Aim. This paper presents a review of the qualitative literature which examines the experiences of patients with coronary heart disease. The paper also assesses whether the experiences of both female and male patients are reflected in the literature and summarizes key themes. Background. Understanding patients' experiences of their illness is important for coronary heart disease prevention and education. Qualitative methods are particularly suited to eliciting patients' detailed understandings and perceptions of illness. As much previous research has been 'gender neutral', this review pays particular attention to gender. Methods. Published papers from 60 qualitative studies were identified for the review through searches in MEDLINE, EMBASE, CINAHL, PREMEDLINE, PsychINFO, Social Sciences Citation Index and Web of Science using keywords related to coronary heart disease. Findings. Early qualitative studies of patients with coronary heart disease were conducted almost exclusively with men, and tended to generalize from 'male' experience to 'human' experience. By the late 1990s this pattern had changed, with the majority of studies including women and many being conducted with solely female samples. However, many studies that include both male and female coronary heart disease patients still do not have a specific gender focus. Key themes in the literature include interpreting symptoms and seeking help, belief about coronary 'candidates' and relationships with health professionals. The influence of social roles is important: many female patients have difficulties reconciling family responsibilities and medical advice, while male patients worry about being absent from work. Conclusions. There is a need for studies that compare the experiences of men and women. There is also an urgent need for work that takes masculinity and gender roles into account when exploring the experiences of men with coronary heart disease

Interpreting Helioseismic Structure Inversion Results of Solar Active Regions

Helioseismic techniques such as ring-diagram analysis have often been used to determine the subsurface structural differences between solar active and quiet regions. Results obtained by inverting the frequency differences between the regions are usually interpreted as the sound-speed differences between them. These in turn are used as a measure of temperature and magnetic-field strength differences between the two regions. In this paper we first show that the "sound-speed" difference obtained from inversions is actually a combination of sound-speed difference and a magnetic component. Hence, the inversion result is not directly related to the thermal structure. Next, using solar models that include magnetic fields, we develop a formulation to use the inversion results to infer the differences in the magnetic and thermal structures between active and quiet regions. We then apply our technique to existing structure inversion results for different pairs of active and quiet regions. We find that the effect of magnetic fields is strongest in a shallow region above 0.985R_sun and that the strengths of magnetic-field effects at the surface and in the deeper (r < 0.98R_sun) layers are inversely related, i.e., the stronger the surface magnetic field the smaller the magnetic effects in the deeper layers, and vice versa. We also find that the magnetic effects in the deeper layers are the strongest in the quiet regions, consistent with the fact that these are basically regions with weakest magnetic fields at the surface. Because the quiet regions were selected to precede or follow their companion active regions, the results could have implications about the evolution of magnetic fields under active regions.Comment: Accepted for publication in Solar Physic

Stakeholder narratives on trypanosomiasis, their effect on policy and the scope for One Health

Background This paper explores the framings of trypanosomiasis, a widespread and potentially fatal zoonotic disease transmitted by tsetse flies (Glossina species) affecting both humans and livestock. This is a country case study focusing on the political economy of knowledge in Zambia. It is a pertinent time to examine this issue as human population growth and other factors have led to migration into tsetse-inhabited areas with little historical influence from livestock. Disease transmission in new human-wildlife interfaces such as these is a greater risk, and opinions on the best way to manage this are deeply divided. Methods A qualitative case study method was used to examine the narratives on trypanosomiasis in the Zambian policy context through a series of key informant interviews. Interviewees included key actors from international organisations, research organisations and local activists from a variety of perspectives acknowledging the need to explore the relationships between the human, animal and environmental sectors. Principal Findings Diverse framings are held by key actors looking from, variously, the perspectives of wildlife and environmental protection, agricultural development, poverty alleviation, and veterinary and public health. From these viewpoints, four narratives about trypanosomiasis policy were identified, focused around four different beliefs: that trypanosomiasis is protecting the environment, is causing poverty, is not a major problem, and finally, that it is a Zambian rather than international issue to contend with. Within these narratives there are also conflicting views on the best control methods to use and different reasoning behind the pathways of response. These are based on apparently incompatible priorities of people, land, animals, the economy and the environment. The extent to which a One Health approach has been embraced and the potential usefulness of this as a way of reconciling the aims of these framings and narratives is considered throughout the paper. Conclusions/Significance While there has historically been a lack of One Health working in this context, the complex, interacting factors that impact the disease show the need for cross-sector, interdisciplinary decision making to stop rival narratives leading to competing actions. Additional recommendations include implementing: surveillance to assess under-reporting of disease and consequential under-estimation of disease risk; evidence-based decision making; increased and structurally managed funding across countries; and focus on interactions between disease drivers, disease incidence at the community level, and poverty and equity impacts

Low-lying T=0 states in the odd-odd N=Z nucleus 62Ga

New, low-lying levels in the odd-odd, N=Z nucleus 62Ga have been identified using a sensitive technique, where in-beam γ rays from short-lived nuclei are tagged with β decays following recoil mass identification. A comparison of the results with shell-model and IBM-4 calculations demonstrates good agreement between theory and experiment, with the majority of predicted low-lying, low-spin T=0 states now identified. There is a dramatic change in the level density at low excitation energies for the N=Z nucleus 62Ga when compared with neighbouring odd-odd Ga isotopes where, in contrast, the low-lying level structure is dominated by configurations with T=1 pairing interactions between excess neutrons. This illustrates the distinctively different aspects of nuclear structure exhibited by nuclei with N=Z

Outcome of patients with undifferentiated embryonal sarcoma of the liver treated according to European soft tissue sarcoma protocols

Background: To assess the outcomes of pediatric patients with undifferentiated embryonal sarcoma of the liver (UESL) and treatment including at least surgery and systemic chemotherapy. Methods: This study included patients aged up to 21 years with a pathological diagnosis of UESL prospectively enrolled from 1995 to 2016 in three European trials focusing on the effects of surgical margins, preoperative chemotherapy, use of radiotherapy (RT), and chemotherapy. Results: Out of 65 patients with a median age at diagnosis of 8.7 years (0.6–20.8), 15 had T2 tumors, and one had lymph node spread, 14 were Intergroup Rhabdomyosarcoma Study (IRS) I, nine IRS II, 38 IRS III, and four IRS IV. Twenty-eight upfront surgeries resulted in five operative spillages and 11 infiltrated surgical margins, whereas 37 delayed surgeries resulted in no spillages (p =.0119) and three infiltrated margins (p =.0238). All patients received chemotherapy, including anthracyclines in 47. RT was administered in 15 patients. With a median follow-up of 78.6 months, 5-year overall and event-free survivals (EFS) were 90.1% (95% confidence interval [CI]: 79.2–95.5) and 89.1% (95% CI: 78.4–94.6), respectively. Two out four local relapses had previous infiltrated margins and two out of three patients with metastatic relapses received reduced doses of alkylating agents. Infiltrated margins (p =.1607), T2 stage (p =.3870), use of RT (p =.8731), and anthracycline-based chemotherapy (p =.1181) were not correlated with EFS. Conclusions: Multimodal therapy improved the outcome of UESL. Neoadjuvant chemotherapy for pediatric patients increases the probability of complete surgical resection. The role of anthracyclines and RT for localized disease remains unclear